Usefulness of anti -CCP antibodies in rheumatic diseases in Indian patients

Gupta, Rajiva; Thabah, Molly Mary; Aneja, Ritu; Kumar, Ashok; Varghese, T; Chandrasenan, PJ

doi:10.4103/0019-5359.49285

Cited by 20 publications

(20 citation statements)

References 23 publications

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“…In the present study, 56.8% of the RA patients were found positive to anti-CCP antibodies while 77.8% were positive to RF antibodies. Unlike earlier studies (Gupta et al, 2009), only 0.05% of RF-negative RA patients were found positive for anti-CCP antibodies in the study group.…”

Section: Discussioncontrasting

confidence: 94%

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Association of single nucleotide polymorphisms (SNPs) of <i>PADI4</i> gene with rheumatoid arthritis (RA) in Indian population

et al. 2012

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Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease affecting ~ 1% of the population worldwide. The genome wide association studies on RA patients revealed linkage with 1p36 locus containing peptidyl arginine deiminase 4 (PADI4) genes. Case-control association studies and mRNA stability assays reported the association of PADI4 gene with RA in Korean and Japanese populations. However, such association was not found in Spanish population. Differences in the association of PADI4 with RA in different populations prompted the present study in Indian population. Anti-CCP antibodies, RF antibody, disease activity scores at 28 joints (DAS28) and mutations in three exons of PADI4 were investigated in RA patients and control group. Among the patients anti-CCP antibody levels were found to be associated with high DAS28 values (r = 0.4526, P < 0.0001). Polymorphism in exon-4 (padi4_104, [rs1748033]) of PADI4 showed significant association of 'C' allele with RA in the study population (P = 0.0008). Polymorphism in exon-3 (padi4_92, [rs874881]) also exhibited moderate association with the disease (P = 0.075). However, no association of the disease was found with the SNPs padi4_89 [rs11203366] and padi4_90 [rs11203367] in exon-2 of PADI4.

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Section: Discussioncontrasting

confidence: 94%

“…The diagnostic and prognostic value for detection of anti-CCP antibodies was shown to be specific to RA patients in various populations (Dubucquoi et al, 2004;Vallbracht and Helmke, 2005;Gupta et al, 2009). In the present study, 56.8% of the RA patients were found positive to anti-CCP antibodies while 77.8% were positive to RF antibodies.…”

Section: Discussionsupporting

confidence: 49%

Association of single nucleotide polymorphisms (SNPs) of <i>PADI4</i> gene with rheumatoid arthritis (RA) in Indian population

et al. 2012

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“…RF (Rheumatoid Factor) assay is 54% to 88% sensitive and 48% to 92% specific, and it is frequently detected in hepatitis and other connective tissue diseases. Among the new antibodies described in the recent years in patients with RA, Anticyclic Citrullinated Peptide (Anti-CCP) antibodies are very specific for RA [7]. A greater number of RA studies in India may include the anti-CCP antibody assay in the future, as its ability to diagnose patients with RA correctly, is established.…”

Section: Methodsmentioning

confidence: 99%

Relationship between Serum 25-Hydroxyvitamin D Levels, Disease Activity and Anti-Cyclic Citrullinated Peptide Antibody Levels in Indian Rheumatoid Arthritis Patients

Borukar¹,

Chogle²,

Deo³

2017

J Rheum Dis Treat

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“…Most studies on the diagnostic utility of the aCCP test in RA have been done in industrialized countries on subjects of European ancestry [6], with only a few done in the developing world [7][8][9][10]. In the absence of any published studies on the prevalence and specificity of aCCP in RA in sub-Saharan Africa, we undertook a cross-sectional case-control study to establish the diagnostic utility of the RF and aCCP tests in urbanized Black South Africans with early RA.…”

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confidence: 99%

The diagnostic utility of the anti-CCP antibody test is no better than rheumatoid factor in South Africans with early rheumatoid arthritis

et al. 2010

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To establish the diagnostic utility of the anticyclic-citrullinated peptide antibody (aCCP) test in Black South Africans with early rheumatoid arthritis (RA). A cross-sectional study comparing the rheumatoid factor (RF) and aCCP status in RA patients and a control group consisting of healthy subjects, and patients with systemic lupus erythematosus (SLE) and scleroderma. The sensitivity, specificity, positive (PPV) and negative predictive values of the aCCP test alone were 82.5%, 84.9%, 87.6% and 79% versus 81.7%, 90.7%, 92.5% and 78% for RF alone. The best specificity (95.3) and PPV (95.8%) was observed when both aCCP and RF tests were positive. Patients with erosive disease had a significantly higher mean RF titre compared with those with non-erosive disease (p=0.007). There was a trend towards an association of smoking (OR=4.1, 95% CI=0.9-18.6) and functional disability (p=0.07) with RF-positive status. No similar clinical associations were observed with aCCP. Almost a third of SLE patients were aCCP positive. Despite the best specificity and PPV observed when both the aCCP and RF tests were positive, our findings suggest that testing for aCCP is only cost-effective in the RF-negative patient in whom there is a strong clinical suspicion of RA.

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Usefulness of anti -CCP antibodies in rheumatic diseases in Indian patients

Abstract: BACKGROUND:The usefulness of anti-cyclic citrullinated peptide antibodies (anti-CCP antibodies)

Cited by 20 publications

References 23 publications

Association of single nucleotide polymorphisms (SNPs) of <i>PADI4</i> gene with rheumatoid arthritis (RA) in Indian population

Association of single nucleotide polymorphisms (SNPs) of <i>PADI4</i> gene with rheumatoid arthritis (RA) in Indian population

Relationship between Serum 25-Hydroxyvitamin D Levels, Disease Activity and Anti-Cyclic Citrullinated Peptide Antibody Levels in Indian Rheumatoid Arthritis Patients

The diagnostic utility of the anti-CCP antibody test is no better than rheumatoid factor in South Africans with early rheumatoid arthritis

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