Usefulness of an Elevated Neutrophil to Lymphocyte Ratio in Predicting Long-Term Mortality After Percutaneous Coronary Intervention

Duffy, Brendan; Gurm, Hitinder S.; Rajagopal, Vivek; Gupta, Ritesh; Ellis, Stephen G.; Bhatt, Deepak L.

doi:10.1016/j.amjcard.2005.10.034

Cited by 373 publications

(335 citation statements)

References 14 publications

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“…Increased inflammation is an important risk factor for recurrent CVD events 2. For example, different studies showed that high white blood cell counts are associated with the recurrence of CVD events and mortality 9, 10, 11, 12, 13. These studies, however, mainly consider total white blood cell count or total lymphocyte counts and do not provide additional information regarding cell‐specific subtypes.…”

Section: Introductionmentioning

confidence: 99%

High Levels of (Un)Switched Memory B Cells Are Associated With Better Outcome in Patients With Advanced Atherosclerotic Disease

Meeuwsen

Duijvenvoorde

Gohar

et al. 2017

JAHA

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BackgroundAtherosclerosis is an inflammatory lipid disorder and the main underlying pathology of acute ischemic events. Despite a vast amount of data from murine atherosclerosis models, evidence of B‐cell involvement in human atherosclerotic disease is limited. We therefore investigated the association of circulating B‐cell subtypes with the occurrence of secondary cardiovascular events in advanced atherosclerotic disease.Methods and ResultsThis cohort study consists of 168 patients who were included in the Athero‐Express biobank between 2009 and 2011. Before surgery, peripheral blood mononuclear cells were isolated and stored in liquid nitrogen. After gentle thawing of the peripheral blood mononuclear cells, different B‐cell subtypes including naïve, (un)switched memory, and CD27+ CD43+ B1‐like B cells, were analyzed by flow cytometry. Univariable and multivariable Cox proportional hazard models were used to analyze associations between B‐cell subtypes, circulating antibodies and secondary cardiovascular manifestations during the 3‐year follow‐up period. Mean age was 70.1±9.6 years, males represented 62.8% of the population, and 54 patients had secondary manifestations during follow‐up. High numbers of unswitched memory cells were protective against secondary outcome (hazard ratio, 0.30 [95% CI, 0.13–0.69]; P<0.01). Similar results were obtained for the switched memory cells that also showed to be protective against secondary outcome (hazard ratio, 0.33 [95% CI, 0.14–0.77]; P=0.01).ConclusionsA high number of (un)switched memory B cells is associated with better outcome following carotid artery endarterectomy. These findings suggest a potential role for B‐cell subsets in prediction and prevention of secondary cardiovascular events in patients with atherosclerosis.

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Section: Introductionmentioning

confidence: 99%

High Levels of (Un)Switched Memory B Cells Are Associated With Better Outcome in Patients With Advanced Atherosclerotic Disease

Meeuwsen

Duijvenvoorde

Gohar

et al. 2017

JAHA

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“…Previous studies reported different markersfrom the differantial white blood cellcount. NLR has been reported as predictive markers in outcomes of endometrial precancerous and cancerous lesions in patients with abnormal uterine bleeding, other cancers and coronary artery disease (Duffy et al, 2006;Halazun et al, 2009;Dirican et al, 2013;Karaman et al, 2013;Unal et al, 2013;Yucel et al, 2013;Acmaz et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Predictive Role of the Neutrophil Lymphocyte Ratio for Invasion with Gestational Trophoblastic Disease

Güzel¹,

Kokanali²,

Erkılınç³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…NLR has been shown to be an independent prognostic factor in various solid tumours, including lung, colorectal, pancreatic, breast, ovarian and gastric cancer [25][26][27][28][29][30]. Furthermore, it has been associated with disease severity, hospitalisation, malnutrition, recurrences and mortality in various chronic diseases, including cardiovascular and kidney diseases [31][32][33]. In recent years, the NLR has also been investigated as diagnostic and prognostic marker in COPD.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil to lymphocyte ratio and clinical outcomes in COPD: recent evidence and future perspectives

et al. 2018

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Chronic obstructive pulmonary disease (COPD) is a disabling condition that is characterised by poorly reversible airflow limitation and inflammation. Acute exacerbations of COPD are a common cause of hospitalisation and death among COPD patients. Several biochemical markers have been studied as outcome predictors in COPD; however, their measurement often requires significant time and resources. Relatively simple biomarkers of inflammation calculated from routine complete blood count tests, such as the neutrophil to lymphocyte ratio (NLR), might also predict COPD progression and outcomes. This review discusses the available evidence from studies investigating the associations between the NLR, COPD exacerbations and death in this patient group.

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Usefulness of an Elevated Neutrophil to Lymphocyte Ratio in Predicting Long-Term Mortality After Percutaneous Coronary Intervention

Cited by 373 publications

References 14 publications

High Levels of (Un)Switched Memory B Cells Are Associated With Better Outcome in Patients With Advanced Atherosclerotic Disease

High Levels of (Un)Switched Memory B Cells Are Associated With Better Outcome in Patients With Advanced Atherosclerotic Disease

Predictive Role of the Neutrophil Lymphocyte Ratio for Invasion with Gestational Trophoblastic Disease

Neutrophil to lymphocyte ratio and clinical outcomes in COPD: recent evidence and future perspectives

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