Usefulness of an early neurofunctional assessment in predicting neurodevelopmental outcome in very low birthweight infants

Picciolini, Odoardo; Giannì, Maria Lorella; Vegni, C; Fumagalli, Monica; Mosca, Fabio

doi:10.1136/adc.2005.073262

Cited by 35 publications

(24 citation statements)

References 29 publications

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“…Picciolini et al reported that neurobehavioural evaluations in early infancy, such as the BRS, may be useful for predicting the neurodevelopmental outcome in VLBW children [33].…”

Section: Discussionmentioning

confidence: 99%

The pilot study: Sphingomyelin-fortified milk has a positive association with the neurobehavioural development of very low birth weight infants during infancy, randomized control trial

Tanaka

Hosozawa

Kudo

et al. 2013

Brain and Development

156

111

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“…Picciolini et al reported that neurobehavioural evaluations in early infancy, such as the BRS, may be useful for predicting the neurodevelopmental outcome in VLBW children [33].…”

Section: Discussionmentioning

confidence: 99%

The pilot study: Sphingomyelin-fortified milk has a positive association with the neurobehavioural development of very low birth weight infants during infancy, randomized control trial

Tanaka

Hosozawa

Kudo

et al. 2013

Brain and Development

156

111

View full text Add to dashboard Cite

“…Multiple methods are available, such as the Amiel-Tison neurological examination, 1 the Touwen Infant Neurological Examination (TINE), 2 the Hammersmith Infant Neurological Examination (HINE), 3 and the neurofunctional assessment of Picciolini et al 4 Little is known about the reliability of these widely used methods. 5 The validity of neurological assessments has been studied to some extent; marked neurological dysfunction during infancy has considerable power to predict developmental disability such as cerebral palsy (CP).…”

Section: Discussionmentioning

confidence: 99%

“…25 Our study confirmed the relationship between preterm birth and MND in infancy. 4,25,26 Signs of MND may be an expression of the lesions of the developing brain associated with preterm birth, such as focal and diffuse damage of the periventricular white matter, and lesions of the thalamus, basal ganglia, and cerebellum. 25,27 Interestingly, we found that small-for-gestational age and preeclampsia were protective factors in the development of MND in the second half of infancy.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The assessment of minor neurological dysfunction in infancy using the Touwen Infant Neurological Examination: strengths and limitations

Hadders‐Algra

Heineman

Bos

et al. 2009

Develop Med Child Neuro

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AIM Little is known of minor neurological dysfunction (MND) in infancy. This study aimed to evaluate the inter-assessor reliability of the assessment of MND with the Touwen Infant Neurological Examination (TINE) and the construct and predictive validity of MND in infancy.METHOD Inter-assessor agreement was determined in a sample of 40 infants (24 males, 16 females) aged 3 to 12 months (25 born at term: gestational age 37-41wks, median 39; and 15 born preterm, gestational age 24-35wks, median 32). Thirty typically developing term infants (18 males, 12 females; gestational age 37-42wks, median 40) and 59 preterm infants (34 males, 25 females) born at <35 weeks' gestation (gestational age 25-34wks, median 29) participated in the validity study. They were neurologically assessed with the TINE at the corrected ages of 4, 6, 10, and 12 months and with the Hempel assessment at 18 months. RESULTSThe findings indicated that MND can be assessed reliably (inter-assessor agreement: kappa=0.83). MND during infancy was related to prenatal, perinatal, and social factors, and in particular to preterm birth. Neurological condition during infancy was prone to change, but was related to neurological condition at 18 months at all ages tested. INTERPRETATIONWe conclude that MND can be determined reliably in infancy. Important considerations in the construct of MND in infancy are its relation to prenatal and perinatal factors, its limited stability, and its moderate predictive value.Neurological assessment is one of the clinical tools used to monitor development in infants at risk for developmental disorders, such as infants born preterm. Multiple methods are available, such as the Amiel-Tison neurological examination, 1 the Touwen Infant Neurological Examination (TINE), 2 the Hammersmith Infant Neurological Examination (HINE), 3 and the neurofunctional assessment of Picciolini et al. 4 Little is known about the reliability of these widely used methods. 5 The validity of neurological assessments has been studied to some extent; marked neurological dysfunction during infancy has considerable power to predict developmental disability such as cerebral palsy (CP). [5][6][7] However, knowledge about the significance of signs of minor neurological dysfunction (MND) during infancy is scarce.Our knowledge of MND is based in particular on data of children above preschool age. Two distinct forms of MND have been distinguished: simple and complex MND.8 Before the onset of puberty the distinction is based on the number of dysfunctions present; after the onset of puberty classification is based on the type of dysfunction. Simple MND may be regarded as the expression of a normal but non-optimally functioning nervous system (minor neurological difference). In contrast, complex MND is the form of MND which is strongly related to pre-and perinatal adversities and to learning and behavioural disorders. From an aetiological point of view, this suggests that it may be considered as a borderline form of CP.8 It is uncertain whether the concept of simple ...

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“…The importance of early assessment at the time of development means that we are not only able to act at an early stage, but also to apply preventive and optimization measures in order to obtain lasting benefits, since what occurs in early infancy has a lasting effect on cognitive capacity, personality, and social behavior (McCormick et al, 2006;Picciolini, Giannì, Vegni, Fumagalli, & Mosca, 2006;Poch et al, 2003;Sonnander, 2000;Stanton-Chapman, Chapman, Bainbridge, & Scott, 2002).…”

Section: Discussionmentioning

confidence: 99%

Early infant cognitive assessment:

Pérez

Sastre-Riba

2010

Behavior Research Methods

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Usefulness of an early neurofunctional assessment in predicting neurodevelopmental outcome in very low birthweight infants

Abstract: Early neurofunctional evaluation may be useful in predicting later neurodevelopmental outcome in VLBW children.

Cited by 35 publications

References 29 publications

The pilot study: Sphingomyelin-fortified milk has a positive association with the neurobehavioural development of very low birth weight infants during infancy, randomized control trial

The pilot study: Sphingomyelin-fortified milk has a positive association with the neurobehavioural development of very low birth weight infants during infancy, randomized control trial

The assessment of minor neurological dysfunction in infancy using the Touwen Infant Neurological Examination: strengths and limitations

Early infant cognitive assessment:

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