Usefulness of a new tactile sensor for measurement of uterine cervical ripening in mice in a quantitative and noninvasive manner

Kaga, Naoyuki; Katsuki, Yuko; C, Kakinuma; Obata, Mitsuko; Shibutani, Yoji; Omata, Sadao

doi:10.1016/0006-355x(96)84155-2

Cited by 3 publications

(4 citation statements)

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“…Characteristically, the cervical collagen fibers and bundles are progressively dissociated and disorganized during pregnancy in several species, including human [12][13][14][15] and mouse [16,17]. The time course of such reorganization in mice correlates with altered mechanical properties of the tissue, such as decreased stiffness [5]. The stromal matrix has been shown to be composed of structural proteins, such as types I and III collagen and elastin, as well as proteoglycans and hyaluronan [12,18].…”

Section: Introductionmentioning

confidence: 98%

“…In the nonpregnant female or very early in pregnancy, the cervical canal is very narrow, and the cervix resists mechanical force to open it. By the end of the pregnancy, however, the cervix softens and becomes highly extensible to permit dilatation and effacement that allows the passage of the newborn through the birth canal in human [3], rat [4], and mouse [5]. Premature cervical softening during the first and early second trimesters may lead to a condition known as incompetent cervix, resulting in recurrent pregnancy loss [6,7].…”

Section: Introductionmentioning

confidence: 99%

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Thrombospondin 2 Deficiency in Pregnant Mice Results in Premature Softening of the Uterine Cervix1

Kokenyesi

Armstrong

Agah

et al. 2004

Biology of Reproduction

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The gradual disorganization of collagen fibers in the stromal connective tissue of the uterine cervix is characteristic of progressive cervical softening during pregnancy. A lack of thrombospondin (TSP) 2 has been shown to be associated with altered collagen fibril morphology of connective-tissue-rich organs such as skin and tendon. The goal of this study was to determine the role of TSP2 in cervical softening by studying a TSP2-null mouse line. Creep testing showed that, in the nonpregnant animal and on Day 10 of pregnancy, there was no difference between the cervical extensibility of the wild-type and the TSP2-deficient mice. However, by Day 14 of pregnancy, the TSP2-null mice showed 4.5-fold increase in cervical extensibility, and by Day 18, a 6.1-fold increase, when compared with wild-type mice. A further indicator of compromised cervical integrity was that, on Days 14 and 18 of pregnancy, the cervix of TSP2-null mice broke rapidly under standard loading conditions that did not break the cervix of wild-type mice. Western blotting showed that TSP2 was expressed in the cervix of mice on Days 14 and 18 of pregnancy but not on Day 10 or in the nonpregnant animal. As determined by immunohistochemistry, the amount of matrix metalloproteinase 2 (MMP2) in the cervix of TSP2-null mice increased 11-fold on Day 14 of pregnancy and 19-fold on Day 18. Thus, TSP2-null mice provide an animal model to assist in the understanding of the molecular basis of spontaneous, premature softening of the uterine cervix.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Thrombospondin 2 Deficiency in Pregnant Mice Results in Premature Softening of the Uterine Cervix1

Kokenyesi

Armstrong

Agah

et al. 2004

Biology of Reproduction

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“…This biosensor has been used in previous studies to measure the effect of hormones on the stiffness of the prostate and bladder Constantinou and Omata, 1996;Lee et al, 1996], the corpora carvernosa in vitro [Hatzichristou et al, 1995], and cervix maturation [Kaga et al, 1996].…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of bladder wall compliance based on cystometry and biosensor measurements during the micturition cycle of the rat

et al. 1997

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“…Kaga et al 59 used a tactile sensor to study uterine cervical ripening in a quantitative and noninvasive manner under various circumstances, including the use of certain chemicals and drugs. The degree of ripening was determined by measuring the hardness of cervical tissue in untreated nonpregnant, pregnant, parturient, and nursing mice.…”

Section: Application To Tissue Propertiesmentioning

confidence: 99%

A review of force and resonance sensors used in the clinical study of tissue properties

Yousuf

Asiyanbola

2013

Proc Inst Mech Eng H

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Tactile sensing is commonly carried out by humans using their fingers or hands to estimate the physical properties of an object. A large body of literature covers a range of applications of these methods in clinical situations. The objective of this work is to show the breadth of application areas explored and the achievements that have been made in the measurement of physical variables of interest to physicians using tactile force and resonance sensors. Although a broad spectrum of applications has been considered, of particular interest is the application of these methods to determine tissue properties in vivo. Progress in this direction has been made by various groups particularly with respect to piezoelectric and capacitance sensors. Also described are the findings of a preliminary study of a tactile system designed to examine the abdomen of the clinically super-obese patient.

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Usefulness of a new tactile sensor for measurement of uterine cervical ripening in mice in a quantitative and noninvasive manner

Cited by 3 publications

References 0 publications

Thrombospondin 2 Deficiency in Pregnant Mice Results in Premature Softening of the Uterine Cervix1

Thrombospondin 2 Deficiency in Pregnant Mice Results in Premature Softening of the Uterine Cervix1

Comparative analysis of bladder wall compliance based on cystometry and biosensor measurements during the micturition cycle of the rat

A review of force and resonance sensors used in the clinical study of tissue properties

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