Usefulness of 2‐[<sup>18</sup>F]‐fluoro‐2‐deoxy‐<scp>d</scp>‐glucose–Positron Emission Tomography/Computed Tomography for Staging and Evaluation of Treatment Response in IgG4‐Related Disease: A Retrospective Multicenter Study

Ebbo, Mikaël; Grados, A.; Guedj, Éric; Gobert, Delphine; Colavolpe, C.; Zaidan, Mohamad; Masseau, A.; Bernard, F.; Berthelot, Jean‐Marie; Morel, Nathalie; Lifermann, François; Palat, S.; Haroche, Julien; Mariette, Xavier; Godeau, Bertrand; Bernit, E.; Costédoat-Chalumeau, Nathalie; Papo, Thomas; Hamidou, M.; Harlé, Jean‐Robert; Schleinitz, N.

doi:10.1002/acr.22058

Cited by 169 publications

(140 citation statements)

References 42 publications

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“…Furthermore, although pseudotumor was not revealed in spleen in both cases, splenic lesions detected by FDG-PET/CT in the present cases might be active involvements of IgG4-RD, considering that splenic lesions, splenomegaly and high FDG uptake in spleen, clinically improved by the treatment as same as other lesions of IgG4-RD. In fact, recent studies suggested that evaluation before and after treatment could show in most IgG4-RD cases a good correlation of FDG-PET/CT results with treatment response and disease activity [8] . Treatment effects could be assessed by the disappearance of FDG uptake [9] .…”

Section: Discussionmentioning

confidence: 99%

Splenic lesion of IgG4-related disease in FDG-PET/CT

Taniguchi

Ogata

Shimamura

et al. 2014

CRIM

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Recent several reports showed that 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) scans accurately, and safely identifies the multiple organs' involvements in IgG4-related diseases (IgG4-RD) patients. Disease activity in two patients, aged 74 and 73 years (serum IgG4, 807 and 1630 mg/dl, respectively), with IgG4-RD were monitored using FDG-PET/CT. Scans before treatment showed splenomegaly with high FDG uptake. Inflammatory aneurysm, submandibular gland swelling, splenomegaly and tubulointerstitial nephritis resolved after treatment with prednisolone. Follow-up FDG-PET/CT at 4 months, with no symptoms, showed a significant decrease in FDG accumulation and improvement of splenomegaly in splenic lesion of IgG4-RD. Thus, splenic lesions detected by FDG-PET/CT might be novel involvements of IgG4-RD.

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Section: Discussionmentioning

confidence: 99%

Splenic lesion of IgG4-related disease in FDG-PET/CT

Taniguchi

Ogata

Shimamura

et al. 2014

CRIM

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“…[6,7]. This term aptly recognizes the ubiquity of IgG4 within involved organs and the frequency of elevated serum IgG4 concentrations.…”

Section: Figmentioning

confidence: 99%

“…Despite uncertainties about its normal function, IgG4 seems to play a significant role in allergic reactions, such as atopic eczema, bronchial asthma, and bullous skin lesions. IgG4 has not attracted the attention of pathologists and clinicians until the recent recognition of the syndrome of IgG4-related disease (IgG4-RD), a fibroinflammatory condition with a marked propensity to present as mass-forming lesions [7,9].…”

Section: Figmentioning

confidence: 99%

Immunoglobulin-g4(IgG4)-rich Pseudotumor of the Kidney – A case report and review of the literature

Savov¹,

Agaimy²,

Rieker³

et al. 2018

JofIMAB

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IgG4-related disease is a newly identified fibroinflammatory condition characterized by tumefactive lesions, a dense lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells and storiform fibrosis. Elevated serum IgG4 levels are frequently observed. IgG4-related disease affects predominantly middle-aged and elderly patients, with male predominance and responds favorably to steroids. The patients present with symptoms referable to the involvement of one or more sites either simultaneously or serially, usually in the form of mass lesions affecting various organs including pancreas, biliary tree, salivary glands, periorbital tissues, kidneys, lungs, retroperitoneum and lymph nodes. The case of a 61-year old male referred for therapy of a 6.6 cm tumorous lesion of the right kidney is presented. Histological assessment of the resected mass showed IgG4-rich sclerosing pseudotumor. The available literature is summarized, and diagnostic and therapeutic options for this condition are discussed. Consideration of a non-malignant disease may be reasonable even in cases of CAT scan findings suggestive of renal cancer.

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“…This entity affects the exocrine glands, lymph nodes, and extranodal tissues, with lymphocytes and high IgG4-secreting plasma cells infiltrate, fibrosclerosis, and obliterating phlebitis, which affect medium-and small-caliber veins. The elevation of serum IgG4 is often present, but not always (1)(2)(3).…”

Section: Introductionmentioning

confidence: 99%

“…Two of the most common characteristics are the presence of a mass or localized inflammation and a history of allergic diseases (1,2,4).…”

Section: Introductionmentioning

confidence: 99%

Study of systemic disease IgG4. Usefulness of 2-[18F]-fluoro-2-deoxy-D-glucose –positron emission tomography/computed tomography for staging, selection of biopsy site , evaluation of treatment response and follow-up

2017

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Immunoglobulin G4-related systemic disease (IgG4-RSD) is a recently emerging disorder characterized by swelling lesions with storiform fibrosis and lymphoplasmacytic infiltration enriched with IgG4-positive plasma cells. IgG4-RSD has been found in multiple organs/ tissues. The diagnosis requires the integration of clinical, serological, imaging, histopathological, and immunohistological features. The 2-[18F]-fluoro-2-deoxy-D-glucose-positron emission tomography/computed tomography (18F-FDG PET/CT) enables the acquisition of whole-body images and provides functional information about disease activity. However, its current role in IgG4-RSD is not well established in clinical practice. In our case, we studied a patient with systemic symptoms, submaxillary adenopathy, and imaging explorations that initially guided toward a lymphoproliferative process. However, the differential diagnosis with an autoimmune systemic disease type IgG4 was considered because of elevated levels of serum immunoglobulins. The study was completed with 18F-FDG PET/ CT that not only allowed us to assess the extension disease and to locate the best lesion for biopsy but also allowed us to evaluate the response to treatment and to diagnose the suspicion of recurrence. In this case, PET/CT shows its usefulness in clinical practice.

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Usefulness of 2‐[¹⁸F]‐fluoro‐2‐deoxy‐d‐glucose–Positron Emission Tomography/Computed Tomography for Staging and Evaluation of Treatment Response in IgG4‐Related Disease: A Retrospective Multicenter Study

Cited by 169 publications

References 42 publications

Splenic lesion of IgG4-related disease in FDG-PET/CT

Splenic lesion of IgG4-related disease in FDG-PET/CT

Immunoglobulin-g4(IgG4)-rich Pseudotumor of the Kidney – A case report and review of the literature

Study of systemic disease IgG4. Usefulness of 2-[18F]-fluoro-2-deoxy-D-glucose –positron emission tomography/computed tomography for staging, selection of biopsy site , evaluation of treatment response and follow-up

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Usefulness of 2‐[18F]‐fluoro‐2‐deoxy‐d‐glucose–Positron Emission Tomography/Computed Tomography for Staging and Evaluation of Treatment Response in IgG4‐Related Disease: A Retrospective Multicenter Study

Cited by 169 publications

References 42 publications

Splenic lesion of IgG4-related disease in FDG-PET/CT

Splenic lesion of IgG4-related disease in FDG-PET/CT

Immunoglobulin-g4(IgG4)-rich Pseudotumor of the Kidney – A case report and review of the literature

Study of systemic disease IgG4. Usefulness of 2-[18F]-fluoro-2-deoxy-D-glucose –positron emission tomography/computed tomography for staging, selection of biopsy site , evaluation of treatment response and follow-up

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Usefulness of 2‐[¹⁸F]‐fluoro‐2‐deoxy‐d‐glucose–Positron Emission Tomography/Computed Tomography for Staging and Evaluation of Treatment Response in IgG4‐Related Disease: A Retrospective Multicenter Study