Usefulness of 1H magnetic resonance spectroscopy in human testes: preliminary study

Baleato-González, Sandra; García‐Figueiras, Roberto; Santiago-Pérez, María Isolina; Requejo-Isidro, I.; Vilanova, Joan C.

doi:10.1016/j.crad.2015.05.010

Cited by 14 publications

(38 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also the study of Baleato-Gonzalez et al confirms the increased choline levels in testis cancer but with a different behavior compared with other tumors: stratifying their population for tumors and varicoceles, these authors describe a reduction in choline concentration due to altered spermatogenesis [15]. In this case, an integration of clinical analysis and several imaging techniques is required to differentiate between neoplastic and benign hypofertility.…”

Section: Discussionmentioning

confidence: 92%

“…Changes in the levels of metabolites (mainly choline), reflect testicular parenchymal alterations [15].…”

Section: Discussionmentioning

confidence: 99%

“…In literature, studies already exists which correlate metabolites variations (mainly choline) with testis cancer; however, to the best of our knowledge, few authors studied the association between parenchymal alterations, metabolites concentrations and spermatogenesis [15,20].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, some authors addressed the application of proton magnetic resonance spectroscopy (1H-MRS) to study the testicular metabolites [15,16].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Role of MR Spectroscopy (H1-MRS) of the Testis in Men with Semen Analysis Altered

Parenti¹,

Albarello²

2016

Reprod Syst Sex Disord

View full text Add to dashboard Cite

Purpose: Proton magnetic resonance spectroscopy (1 H-MRS) has been proposed as a tool to assess male infertility providing metabolic signatures related to the spermatogenesis in the testis. This study sought to identify the role of 1 H-MRS in the diagnosis of infertility in patients with semen analysis altered. Materials and Methods:14 patients (27 testicles) with fertility problems and with an altered semen analysis (5 oligospermia, 3 asthenospermia, 6 oligoasthenospermia) and 9 controls (18 testicles) with normal spermatogenesis assessed (men with prior paternity and normal semen analysis) and normal testicles at magnetic resonance (MR) and ultrasonography (US) with colour Doppler (CD) examination were included. All patients underwent testis US and CD investigation, conventional MR examination at 1.5T including T1 and T2 weighted images in three orthogonal planes and proton magnetic resonance spectroscopy (1 H-MRS) with single-voxel PRESS (TR 2000 ms / TE 31 ms). Major metabolites peaks (choline, creatine, lipids, lactate) were calculated and compared between the patients and controls.Results: Mean choline peak in the semen analysis altered group was statistically significantly lower than the normal group (0.69 vs 1.34, 95% CI: 0.52 -0.85; p < 0.001). 18 testicles within semen analysis altered group (66,7%) had both MR and US examination negative but mean choline peak lower then controls (1.09 vs 1.34, p < 0.001). 7 testicles of those presented also varicocele at CD investigation. Conclusion:1 H-MRS revealed a significant shift towards lower choline peak in patients with semen analysis altered compared to controls with normal spermatogenesis. Moreover 1 HMRS provided to find out spermatogenesis disorder in patients with normal testis at MR and US examination.

show abstract

Section: Discussionmentioning

confidence: 92%

“…Changes in the levels of metabolites (mainly choline), reflect testicular parenchymal alterations [15].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Recently, some authors addressed the application of proton magnetic resonance spectroscopy (1H-MRS) to study the testicular metabolites [15,16].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Role of MR Spectroscopy (H1-MRS) of the Testis in Men with Semen Analysis Altered

Parenti¹,

Albarello²

2016

Reprod Syst Sex Disord

View full text Add to dashboard Cite

show abstract

“…Proton magnetic resonance spectroscopy (1H‐MRS) represents a noninvasive functional imaging technique, used as an adjunct tool to conventional MRI, providing metabolic information for normal and abnormal tissues (Shin, Baek, Cha, & Kim, 2012; Stoffey, 2011; Vassiou et al, 2013). Recently, applications of 1H‐MRS in the study of normal and pathologic testes have been reported (Aaronson, Iman, Walsh, Kurhanewicz, & Turek, 2010; Baleato‐González, García‐Figueiras, Santiago‐Pérez, Requejo‐Isidro, & Vilanova, 2015; Firat et al, 2008; Parenti, Albarello, & Campioni, 2016; Storey et al, 2018; Tsili et al, 2016). Several metabolic peaks in 1H‐MR spectra of normal adult testes have been described on a 1.5 T magnet, with most prominent peaks those of choline (Cho), creatine (Cr), myo‐inositol (mI) and lipids (Tsili et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Are there differences in the biochemical profile of bilateral normal testes? A 3.0 T 1H‐MR spectroscopy study

et al. 2020

View full text Add to dashboard Cite

Bilateral normal testes asymmetry represents an interesting phenomenon. The aim was to assess possible differences in the biochemical profile of bilateral normal testes by 3.0 T proton magnetic resonance spectroscopy (1H‐MRS). Twenty‐one men were examined with scrotal 3.0 T MRI, including a single‐voxel point‐resolved spectroscopy sequence. MR spectra were obtained by placing a volume of interest in the middle of each normal testis. Normalised metabolite concentrations, defined as ratios of the calculated metabolite concentrations relative to creatine (Cr) concentration, were compared between bilateral normal testes using Mann–Whitney U test. 1H‐MRS allowed the detection of certain testicular metabolites, including total choline, Cr, myo‐inositol, Glx, total lipids and macromolecules resonating at 0.9, 1.3 and 2.0 ppm. Normal left testis had higher median normalised concentrations of Glx (p = .002) and lactate (p = .041) compared with the normal right testis. Differences in concentrations of Glx were attributed to differences in glutamate (p = .020). Normal testes asymmetry is confirmed in this study by differences in the biochemical testicular profile, as assessed by 3.0 T 1H‐MRS. Increase in levels of glutamate and lactate in normal left testis should be correlated with changes in metabolic pathways, specifically glycometabolism and amino acid metabolism.

show abstract

Proton MR Spectroscopy in Assessing the Biochemical Milieu of Human Testes

Tsili

Astrakas

Sofikitis

et al. 2020

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Proton magnetic resonance spectroscopy (MRS), considered a connection between metabolism and anatomic and functional information provided by standard MRI, gives information on various tissue metabolites and their pathologic changes. Recently, proton MRS has been added as an adjunct tool to the multiparametric protocol of scrotal MRI, providing a new insight into the extremely complex biochemical milieu of normal and abnormal testes. This article reviews proton MR spectra of normal testes, showing age and bilateralism dependence. Disturbances of various metabolic pathways in testes of infertile men resulting in alterations of metabolite peaks are discussed. Preliminary data on proton MR spectra of testicular mass lesions are presented. Level of Evidence: 5. Technical Efficacy Stage: 5.

show abstract

Usefulness of 1H magnetic resonance spectroscopy in human testes: preliminary study

Cited by 14 publications

References 30 publications

Role of MR Spectroscopy (H1-MRS) of the Testis in Men with Semen Analysis Altered

Role of MR Spectroscopy (H1-MRS) of the Testis in Men with Semen Analysis Altered

Are there differences in the biochemical profile of bilateral normal testes? A 3.0 T 1H‐MR spectroscopy study

Proton MR Spectroscopy in Assessing the Biochemical Milieu of Human Testes

Contact Info

Product

Resources

About