Usefulness in predicting coronary artery disease by ultrasonic evaluation of the carotid arteries in asymptomatic hypercholesterolemic patients with positive exercise stress tests

Giral, Philippe; Bruckert, Éric; Dairou, F.; K, Boubrit; Drobinski, G; Chapman, John; Beucler, I.; Turpin, G

doi:10.1016/s0002-9149(99)00184-8

Cited by 36 publications

(27 citation statements)

References 16 publications

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“…45 Finally, increased levels of carotid artery IMT have been associated with positive exercise test results. 46,47 Accordingly, the finding of a significant association between a quantitative abnormality of the carotid IMT and evidence of established CAD is reassuring and is concordant with the principle that atherosclerosis is a diffuse disease. Detection in one bed implies a high likelihood of association with atherosclerosis in a different bed.…”

Section: Methodsmentioning

confidence: 59%

Surrogate Markers for Cardiovascular Disease

2004

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Section: Methodsmentioning

confidence: 59%

Surrogate Markers for Cardiovascular Disease

2004

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“…24 In a study of asymptomatic hypercholesterolemic patients, carotid plaque demonstrated by B-mode ultrasound significantly improved the diagnostic specificity of exercise electrocardiography in predicting atherosclerotic lesions by coronary angiography. 25 May plaque morphology assessed in one arterial territory reflect the individual's plaque morphology in other arterial territories due to a common underlying systemic factor? This possibility has been suggested earlier.…”

Section: Discussionmentioning

confidence: 99%

Carotid Atherosclerosis Is a Stronger Predictor of Myocardial Infarction in Women Than in Men

Johnsen

Mathiesen

Joakimsen

et al. 2007

Stroke

358

194

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Background and Purpose-Ultrasound of carotid arteries provides measures of intima media thickness (IMT) and plaque, both widely used as surrogate measures of cardiovascular disease. Although IMT and plaques are highly intercorrelated, the relationship between carotid plaque and IMT and cardiovascular disease has been conflicting. In this prospective, population-based study, we measured carotid IMT, total plaque area, and plaque echogenicity as predictors for first-ever myocardial infarction (MI). Methods-IMT, total plaque area, and plaque echogenicity were measured in 6226 men and women aged 25 to 84 years with no previous MI. The subjects were followed for 6 years and incident MI was registered. Results-During follow-up, MI occurred in 6.6% of men and 3.0% of women. The adjusted relative risk (RR; 95% CI) between the highest plaque area tertile versus no plaque was 1.56 (1.04 to 2.36) in men and 3.95 (2.16 to 7.19) in women. In women, there was a significant trend toward a higher MI risk with more echolucent plaque. The adjusted RR (95% CI) in the highest versus lowest IMT quartile was 1.73 (0.98 to 3.06) in men and 2.86 (1.07 to 7.65) in women. When we excluded bulb IMT from analyses, IMT did not predict MI in either sex. Conclusions-In a general population, carotid plaque area was a stronger predictor of first-ever MI than was IMT. Carotid atherosclerosis was a stronger risk factor for MI in women than in men. In women, the risk of MI increased with plaque echolucency.

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“…18 According to Giral et al a positive exercise electrocardiogram is not infrequent occurrence in asymptomatic hypercholesterolemic patients, but the number of false positive tests may be relatively high (50%). 19 TMT was also positive in one patient with LAE, 2 patients of low voltage complex, 5 patients with non specific ST-T changes and one patient with sinus bradycardia in ECG findings. Study by MiSAD group et al concluded that abnormalities in ECG at rest had the highest odds ratio (9.27) for TMT positivity and ST-T abnormalities in ECG at rest is an important predicting factor for silent CAD in T2DM patients and suggests an indication of performance of further investigations in presence of these abnormalities.…”

Section: Discussionmentioning

confidence: 86%

A Prospective Study of Tread Mill Test in Postmenopausal Women

Sonwani¹,

Rawat²,

Rastogi³

et al. 2018

IJCMR

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Introduction: Cardiovascular disease (CVD) accounts for 45% mortality in women. In post menopausal women risk factors like hypertension, dyslipidemia, obesity and diabetes are increasing. Cardiovascular risk assessment should be done at time of menopause and at regular intervals to detect cardiovascular disorders at the earliest. Current research aimed to study symptomatology and biochemical parameter and its relationship with ECG and TMT in postmenopausal women.

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Usefulness in predicting coronary artery disease by ultrasonic evaluation of the carotid arteries in asymptomatic hypercholesterolemic patients with positive exercise stress tests

Cited by 36 publications

References 16 publications

Surrogate Markers for Cardiovascular Disease

Surrogate Markers for Cardiovascular Disease

Carotid Atherosclerosis Is a Stronger Predictor of Myocardial Infarction in Women Than in Men

A Prospective Study of Tread Mill Test in Postmenopausal Women

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