Usefulness and limitations of single-slice computed tomography analysis at the third lumbar region in the assessment of sarcopenia

Safer, Vildan Binay; Safer, Umut

doi:10.1186/cc13123

Cited by 17 publications

(6 citation statements)

References 5 publications

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“…In 1971, the CT scan was the first clinically accepted body composition measurement tool and was used as a gold standard [ 34 ]. The CT scan uses an X-ray beam to make cross-sectional images of the body, which can estimate total body fat, visceral fat and skeletal muscle mass [ 40 , 41 ]. A single cross-sectional image of the abdominal area at the level of the L3 has shown a high correlation with total body skeletal muscle mass and body adipose tissue, comparable to whole-body MRI results [ 42 ].…”

Section: Methods Of Measuring Muscle Massmentioning

confidence: 99%

Measuring Muscle Mass and Strength in Obesity: a Review of Various Methods

et al. 2020

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Lower muscle mass in populations with obesity is associated obesity-related diseases like hypertension and type 2 diabetes mellitus. Bariatric surgery leads to sustained weight loss. During the weight reduction, loss of muscle should be minimized. Thus reliable quantification of muscle mass is much needed and therefore the also the need for validated methods. Imaging methods, magnetic resonance imaging and computed tomography scan, have been the gold standard for many years. However, these methods are costly and have limitations such as the maximum weight. Dual-energy X-ray absorptiometry is currently the most used alternative. Other, less expensive methods are very limited in their validation in populations with morbid obesity. This narrative review summarizes the current knowledge regarding measuring muscle mass and strength in obesity.

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Section: Methods Of Measuring Muscle Massmentioning

confidence: 99%

Measuring Muscle Mass and Strength in Obesity: a Review of Various Methods

et al. 2020

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“…Lean body mass (LBM) and sarcopaenia will be analysed using the CT scans systematically available from routine care. CT scan cross-section at the level of the third lumbar vertebra provides a reliable representation of the total body muscle mass and has therefore been widely adopted for the detection of sarcopaenia in patients with cancer and allows assessment without additional ionising radiation exposure given that CT scans as part of routine cancer diagnostic procedures is largely available 44 45. The thresholds for identifying muscle range from −29 to +150 Hounsfield Units (HU), subcutaneous and intramuscular adipose tissue from −190 to −30 HU, visceral adipose tissue from −150 to −50 HU and bone from +152 to 1000 HU 46–48.…”

Section: Methodsmentioning

confidence: 99%

Effect of acute aerobic exercise before immunotherapy and chemotherapy infusion in patients with metastatic non-small-cell lung cancer: protocol for the ERICA feasibility trial

Gouez

Pérol

et al. 2022

BMJ Open

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IntroductionPatients with metastatic non-small cell lung cancer (mNSCLC) suffer from numerous symptoms linked to disease and treatment which may further impair the patient’s overall condition. In addition to its benefits on quality of life and fatigue, physical exercise may improve treatment response, notably due to its known effects on the immune system. The ERICA study is designed to assess the feasibility of a supervised acute physical exercise therapy realised immediately prior immune-chemotherapy infusion in patients with mNSCLC. Secondary objectives will examine the effects of acute exercise combined with an unsupervised home-walking programme on clinical, physical, psychosocial and biological parameters.Methods and analysisERICA is a prospective, monocentric, randomised controlled, open-label feasibility study conducted at the Centre Léon Bérard Comprehensive Cancer Center (France). Thirty patients newly diagnosed with mNSCLC will be randomised (2:1 ratio) to the ‘exercise’ or the ‘control’ group. At baseline and during the last treatment cycle, participants in both groups will receive Physical Activity recommendations, and two nutritional assessments. In the exercise group, participants will receive a 3-month programme consisting of a supervised acute physical exercise session prior to immune-chemotherapy infusion, and an unsupervised home-based walking programme with an activity tracker. The acute exercise consists of 35 min interval training at submaximal intensity scheduled to terminate 15 min prior to infusion. Clinical, physical, biological and psychosocial parameters will be assessed at baseline, 3 and 6 months after inclusion. Biological measures will include immune, inflammatory, metabolic, oxidative stress biomarkers and molecular profiling.Ethics and disseminationThe study protocol was approved by the French ethics committee (Comité de protection des personnes Ile de France II, N°ID-RCB 20.09.04.65226, 8 December 2020). The study is registered on ClinicalTrials.gov (NCT number:NCT04676009) and is at the pre-results stage. All participants will sign an informed consent form. The findings will be disseminated in peer-reviewed journals and academic conferences.

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“…However, we would like to focus on some methodological issues of the article by Delrieu et al Delrieu et al made the definition of sarcopenia, based on single slice computed tomography (CT) analysis at the third lumbar (L3) vertebra. The cross-sectional area of the seven muscles of the L3 region (psoas, rector spinae, quadratus lumborum, transversus abdominus, external and internal obliques and rectus abdominus) was assessed by measuring the area.This method has been used a lot in studies, but its validity has not been fully approved [2]. It is not recommended in recent update of the Asian Working Group for Sarcopenia consensus, so muscle mass analyze based on single slice computed CT analysis is not the widely accepted methodology [3].…”

Section: Dear Editormentioning

confidence: 99%