Useful parameters for distinguishing nonalcoholic steatohepatitis with mild steatosis from cryptogenic chronic hepatitis in the Japanese population

Tanaka, Naoki; Tanaka, Eiji; Sheena, Yo; Komatsu, Michiharu; Okiyama, Wataru; Misawa, Noriko; Muto, Hidetomo; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Horiuchi, Akira; Kiyosawa, Kendo

doi:10.1111/j.1478-3231.2006.01338.x

Cited by 26 publications

(31 citation statements)

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“…In patients who refused liver biopsy, the diagnosis was made using a formula for estimating liver cirrhosis proposed by Ikeda et al 11 Diagnoses were then further corroborated by imaging findings, such as the presence of liver surface irregularities, swelling of the left or caudal lobes, the presence of splenomegaly, and development of esophageal and/or gastric varices. 8 …”

Section: Diagnosis Of Lcmentioning

confidence: 99%

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Efficacy and safety of addition of minor bloodletting (petit phlebotomy) in hepatitis C virus-infected patients receiving regular glycyrrhizin injections

et al. 2009

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Section: Diagnosis Of Lcmentioning

confidence: 99%

“…Patients were considered to have diabetes if they had a fasting glucose level equal to or higher than 126 mg/dl, or if they were taking insulin or oral hypoglycemic drugs. [8][9][10] …”

Section: Patientsmentioning

confidence: 99%

Efficacy and safety of addition of minor bloodletting (petit phlebotomy) in hepatitis C virus-infected patients receiving regular glycyrrhizin injections

et al. 2009

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“…Patients were considered to be diabetic if they had a fasting glucose level equal to or higher than 7.0 mmol/L (126 mg/dL) or if they were taking insulin or oral hypoglycemic drugs. Patients were considered to have hyperlipidemia if their fasting serum levels of cholesterol or triglyceride were equal to or higher than 5.7 mmol/L (220 mg/dL) or 1.7 mmol/L (150 mg/dL), respectively, or if they were taking lipid-lowering drugs [18]. The presence of metabolic syndrome was judged according to the criteria released by the Japanese Committee for the Diagnostic Criteria of Metabolic Syndrome [19].…”

Section: Analysis Of Clinical Featuresmentioning

confidence: 99%

“…The homeostasis model assessment of insulin resistance (HOMA-IR), a simple and reliable indicator of insulin resistance, was calculated by the following formula: [fasting plasma glucose (mmol/L) x immunoreactive insulin (μU/mL)]/22.5. A HOMA-IR of greater than 2 was defined as the presence of insulin resistance [18]. Serum pancreatic secretory trypsin inhibitor (PSTI) concentration was measured by immunoradiometric assay (Eiken Chemical Co., Ltd, Tokyo, Japan).…”

Section: Laboratory and Biochemical Examinationmentioning

confidence: 99%

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Citrin deficiency as a cause of chronic liver disorder mimicking non-alcoholic fatty liver disease

Komatsu

Yazaki

Tanaka

et al. 2008

Journal of Hepatology

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NAS, NAFLD activity score; ROC, receiver-operating characteristic; AUC, area under the ROC curve; γGT, γ-glutamyltransferase; HCC, hepatocellular carcinoma.2 Abstract Background/Aims: Citrin deficiency caused by SLC25A13 gene mutations develops into adult-onset type II citrullinemia (CTLN2) and may be accompanied with hepatic steatosis and steatohepatitis. As its clinical features remain unclear, we aimed to explore the characteristics of fatty liver disease associated with citrin deficiency. Methods: The prevalence of hepatic steatosis in 19 CTLN2 patients was examined, and clinical features were compared with those of nonalcoholic fatty liver disease (NAFLD) patients without known SLC25A13 gene mutations. Results: Seventeen (89%) CTLN2 patients had steatosis, and 4 (21%) had been diagnosed as having NAFLD before appearance of neuropsychological symptoms. One patient had steatohepatitis. Citrin deficiency-associated fatty livers showed a considerably lower prevalence of accompanying obesity and metabolic syndrome, higher prevalence of history of pancreatitis, and higher serum levels of pancreatic secretory trypsin inhibitor (PSTI) than fatty livers without the mutations. Receiver operating characteristic curve analyses revealed that a body mass index < 20 kg/m 2 and serum PSTI > 29 ng/mL were associated with citrin deficiency. Conclusion: Patients presenting with nonalcoholic fatty liver unrelated to obesity and metabolic syndrome might have citrin deficiency, and serum PSTI may be a useful indicator for distinguishing this from conventional NAFLD.

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Impact of qualitative endoscopic ultrasonography on fatty pancreas at a referral medical center

et al. 2021

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Background Taking advantage of the current advances in diagnostic imaging modalities, including endoscopic ultrasonography (EUS), and due to the increased attention to ectopic fat accumulation in the pancreas following the rising trend of metabolic syndrome, we qualitatively assessed the clinical implication of pancreatic steatosis by EUS in this study. Methods The study included 243 patients that were divided into four groups. The correlation between the average echogenicity of the pancreas and that of the control organs and the key clinical data of all study patients were collectively analyzed. The cut‐off point of the pancreas‐control (PC) ratio in EUS and liver‐control (LC) ratio on abdominal ultrasound were determined from the population distribution and the obtained median values. Results With the cut‐off point of 1.30 for the PC ratio and 1.20 for the LC ratio, sex, the Brinkman index, habitual alcohol drinkers, and fatty pancreas were significant factors. The associations between each relevant factor in fatty pancreas, metabolic syndrome in the fatty liver group, and age in the pancreatic cancer group were all significant in the analysis. In addition, we investigated whether the PC ratio differed according to age and staging in pancreatic cancer patients. Interestingly, the PC ratio was lower in the advanced stage group than in the early‐stage group. Conclusion Our results suggest that, irrespective of the degree, ectopic fat infiltration in the pancreas could be a specific clinical phenotype of serious pancreatic diseases, including pancreatic cancer, especially in high‐risk patients.

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Useful parameters for distinguishing nonalcoholic steatohepatitis with mild steatosis from cryptogenic chronic hepatitis in the Japanese population

Abstract: Background/Aims: Since detecting mild steatosis is difficult by abdominal

Cited by 26 publications

References 20 publications

Efficacy and safety of addition of minor bloodletting (petit phlebotomy) in hepatitis C virus-infected patients receiving regular glycyrrhizin injections

Efficacy and safety of addition of minor bloodletting (petit phlebotomy) in hepatitis C virus-infected patients receiving regular glycyrrhizin injections

Citrin deficiency as a cause of chronic liver disorder mimicking non-alcoholic fatty liver disease

Impact of qualitative endoscopic ultrasonography on fatty pancreas at a referral medical center

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