Useful Effects of Curcumin Supplementation on Gastric Superoxide Dismutase Activity and Serum Malondialdehyde Level During Endurance Training in Male Wistar Rats

Abstract

Background: Strenuous endurance training triggers the antioxidant defenses of the body and attempts to find supplements to heal gastric ulcers induced by strenuous endurance training and increased body oxidant status. Objectives: Therefore, the current study aimed at investigating the effects of curcumin supplementation during nine weeks of endurance training on gastric antioxidant capacity (superoxide dismutase; SOD) and serum lipid peroxidation (malondialdehyde; MDA) in male Wistar rats. Methods: The current applied research was conducted on 26 male Wistar rats aged nine weeks and weighed 215.87 ± 20.49 g. After one week of acclimation to training, the rats were randomly assigned to four groups: the control, curcumin, endurance, and endurance + curcumin. During the nine weeks (five sessions per week), the rats performed an incremental endurance training (up to 70 minutes at 35 m/minute), and the curcumin supplement at 30 mg/kg of body weight was injected intraperitoneally three times per week. SOD activity was assayed by the spectrophotometric method, and serum MDA level was measured utilizing the thiobarbituric acid reactive substances. For data analysis, ANOVA was employed using SPSS version 24. Results: The results of the study revealed that strenuous endurance training significantly reduced the activity of the gastric SOD enzyme (P < 0.05) and increased serum MDA level (P < 0.05), while curcumin supplementation increased gastric SOD enzyme activity, decreased serum MDA level, and resulted in the restoration of antioxidant defenses. Conclusions: Prolonged strenuous endurance training induces oxidative stress to gastric tissue, and curcumin supplementation restores the antioxidant defense of the gastric tissue and body.

Defensive potential and deleterious impact of turmeric ( Curcuma longa ) L rhizome powder supplemented diet on antioxidant status of indomethacin‐induced ulcerated wistar rats

“…The attenuating effect of turmeric rhizome powder was more than that of omeprazole here. This is in line with previous studies which presented that curcumin supplementation increased gastric SOD enzyme activity and thereby restores the antioxidant defense of tissues and body (Gorzi & Asadi, 2020).…”

Isometric training promotes changes in acetylcholinesterase and muscle strength

“…Our data demonstrated significant increases in AChE activity in the SOL muscle in accordance with the results of the Gorzi et al (2013), which have evaluated A12 isoform of AChE after endurance training with running. In that study, the authors suggested that the increased AChE activity related to augment resistance to fatigue was due to the higher storage capacity and consequently greater release of acetylcholine in the neuromuscular junction by motoneurons (Gorzi et al, 2013). According to Navarrete & Vrbova (1983), large magnitude adaptations to the exercise are expected as the isometric contraction of the slow contraction muscles are tonically activated.…”

“…In fact, denervation induces the AChE activity and expression and elicits the loss of muscle mass (Decker & Berman, 1990). In contrast, rats submitted to running can show increased AChE activity (Gorzi et al, 2013). Again, this enzymatic alteration seems to occur in parallel to zoometric changes induced by exercise as this exercise protocol can induce muscle mass gain in rats (Bonnet et al, 2007).…”

Andrographis paniculata as Promising Novel Protective Therapy of Oxidative Stress in Indomethacin-Induced Gastric Ulcer in Rats

“…Glutathione peroxidase level was measured by the method as reported by Abarikwu et al [28]. Superoxide dismutase level was measured by the method as reported by Gorzi and Asadi [29]. Catalase level was measured by the method as reported by Safaeian et al [30].…”