1960
DOI: 10.1001/archinte.1960.03820050075014
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Useful Drugs in the Treatment of Cancer

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1961
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Cited by 13 publications
(4 citation statements)
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“…Another factor that increased the stakes was the scarcity of candidate drugs. The CCNSC screened hundreds of thousands of compounds in animals and tissue cultures, but over 90% were rejected at as they proved to be either too toxic or ineffective (CCR 1, 1959;CCNSC Advisory Council Meeting Minutes, 1955, 1956Zubrod, 1960Zubrod, , 1984Zubrod et al, 1977). Only a handful of compounds showed acceptable 'therapeutic ratios' (i.e.…”
Section: What Is An Anticancer Drug?mentioning
confidence: 99%
“…Another factor that increased the stakes was the scarcity of candidate drugs. The CCNSC screened hundreds of thousands of compounds in animals and tissue cultures, but over 90% were rejected at as they proved to be either too toxic or ineffective (CCR 1, 1959;CCNSC Advisory Council Meeting Minutes, 1955, 1956Zubrod, 1960Zubrod, , 1984Zubrod et al, 1977). Only a handful of compounds showed acceptable 'therapeutic ratios' (i.e.…”
Section: What Is An Anticancer Drug?mentioning
confidence: 99%
“…The antitumor effect of actinomycin D on animal [9,10,14,40,47] and human tumors [15,27,31,41,48,49] has been studied by many investigators and this agent is effective in treating two childhood neoplasms, Wilms' tumor [15,27,31,32,41,49,59] and embryonal rhabdomyosarcoma [31, 41,59]. 1 Daunomycin, a glycoside antibiotic, was isolated from cultures of Streptomyces peucetius [18].…”
Section: Introductionmentioning
confidence: 99%
“…N o r is it o u r purpose to re p o rt on th e lite ra tu re , w hich has in creased in in verse p ro p o rtio n to its clinical im p o rta n c e . W e w ish to m en tio n only som e su m m a ry re p o rts dealing w ith th e se su b sta n c e s [1,3,15,19,20,23]. [4], M oreover o u r o b je c t w as to use a m in im u m o f anim als for th is s tu d y , an d to exam ine all o f th em m acroscopically an d m icroscopically in th e to x icity te s t, to get fu rth e r in fo rm a tio n on th e a c tiv a tio n o f C yclophospham ide.…”
mentioning
confidence: 99%