Use tests: ROAT (repeated open application test)/PUT (provocative use test): an overview

2003

Self Cite

The fragrance material anisyl alcohol has been cited as a moderately frequent cause of allergic contact dermatitis. A review of the literature shows that when the underlying clinical and experimental data are analyzed, a clear cause-effect relationship has infrequently or rarely been established. On the basis of the generally weak sensitizing potential of this substance coupled with its generally low exposure conditions, the prevalence of clinical cases would not be expected to be particularly high. This is not to say that anisyl alcohol is a frequent inducer of type IV allergy in members of the public. However, it remains to be seen how often such an allergy, once established, is responsible for any of the cases of allergic contact dermatitis commonly ascribed in the literature. Indeed, in some cases, patch test conditions may not be optimal for differentiating between clinically relevant and irrelevant allergy to anisyl alcohol.

Section: Resultsmentioning

confidence: 99%

Is There Evidence that Anisyl Alcohol Causes Allergic Contact Dermatitis?

Hostýnek¹,

2003

Self Cite

“…This should be simplifi ed when more data becomes available as to appropriate non-irritant patch test concentrations and vehicles together with clinical correlations to provocative use test/repeat open application tests [24] . Recent expedited schemata for providing fragrance allergens should be of value [25] .…”

Section: Discussionmentioning

confidence: 99%

Is There Evidence That Alpha-Iso-Methylionone Causes Allergic Contact Dermatitis?

Hostýnek¹,

2004

Self Cite

The fragrance material alpha-iso-methylionone, or ‘gamma-methylionone’, has been cited as a moderately frequent cause of allergic contact dermatitis. A review of the literature shows that when the underlying clinical and experimental data are analyzed, a clear cause-effect relationship has infrequently or rarely been established. On the basis of the generally weak sensitizing potential of this substance, coupled with its generally low exposure conditions, the prevalence of clinical cases would not be expected to be particularly high. This is not to say that alpha-iso-methylionone is a frequent inducer of low-intensity but sub-clinical, type IV allergy in members of the public. It remains to be seen however, how often such allergy, once established, is responsible for any of the cases of allergic contact dermatitis commonly ascribed in the literature. Indeed, in some cases, patch test conditions may not be optimal for differentiating between clinically relevant and irrelevant allergy to alpha-iso-methylionone. Prospective screening patch test studies combined with appropriate follow-up to ascertain clinical relevance should clarify these issues.

“…This should be simplified when more data become available as to appropriate nonirritant patch test concentrations and vehicles together with clinical correlations with provocative use test/repeat open application tests [Nakada et al, 2000]. Recent expedited schemata for providing fragrance allergens should be of value [Vey, 2003].…”

Section: Discussionmentioning

confidence: 99%

Is There Evidence that Linalool Causes Allergic Contact Dermatitis?

Hostýnek¹,

2003

Self Cite

The fragrance material linalool has been cited as a moderately frequent cause of allergic contact dermatitis. The literature shows that when the underlying clinical and experimental data are analyzed, a clear cause-effect relationship has infrequently or rarely been established. On the basis of the generally weak sensitizing potential of this substance coupled with its generally low exposure conditions, the prevalence of clinical cases would not be expected to be particularly high. This is not to say that linalool is a frequent inducer of type IV allergy in members of the public. However, it remains to be seen how often such an allergy, once established, is responsible for any of the cases of allergic contact dermatitis commonly ascribed in the literature. Indeed, in some cases, patch test conditions may not be optimal for differentiating between clinically relevant and irrelevant allergy to linalool.