Use of β-Alanine as an Ergogenic Aid

Derave, Wim

doi:10.1159/000345825

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…β-Alanine is considered one of the more popular supplements used by competitive athletes [ 38 , 44 , 45 , 46 ]. Supplementation with β-alanine is known to significantly enhance athletic performances during high-intensity prolonged activity [ 47 , 48 , 49 , 50 ].…”

Section: Efficacy Of β-Alanine Supplementationmentioning

confidence: 99%

The Effect of β-Alanine Supplementation on Performance, Cognitive Function and Resiliency in Soldiers

Ostfeld

Hoffman

2023

Nutrients

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β-alanine is a nonessential amino acid that combines with the amino acid histidine to form the intracellular dipeptide carnosine, an important intracellular buffer. Evidence has been well established on the ability of β-alanine supplementation to enhance anaerobic skeletal muscle performance. As a result, β-alanine has become one of the more popular supplements used by competitive athletes. These same benefits have also been reported in soldiers. Evidence accumulated over the last few years has suggested that β-alanine can result in carnosine elevations in the brain, which appears to have broadened the potential effects that β-alanine supplementation may have on soldier performance and health. Evidence suggests that β-alanine supplementation can increase resilience to post-traumatic stress disorder, mild traumatic brain injury and heat stress. The evidence regarding cognitive function is inconclusive but may be more of a function of the stressor that is applied during the assessment period. The potential benefits of β-alanine supplementation on soldier resiliency are interesting but require additional research using a human model. The purpose of this review is to provide an overview of the physiological role of β-alanine and why this nutrient may enhance soldier performance.

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Section: Efficacy Of β-Alanine Supplementationmentioning

confidence: 99%

The Effect of β-Alanine Supplementation on Performance, Cognitive Function and Resiliency in Soldiers

Ostfeld

Hoffman

2023

Nutrients

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“…(a) L-citrulline [138]: daily supplementation of 6 g.kg −1 body weight.day during 1 week enhances maximal power (+14% W) and sustained time in seconds (+13%) (b)ß-alanine [139]: derived from carnosine (a dipeptide), the use of ß-alanine was tested 10 years ago in [178] humans by Roger Harris [140]. A meta-analysis [141] and some reviews [139,142] concluded to positive effects while looking to intensive short-time (1-4 min) exercises.…”

Section: A) Classical Protein Feedingmentioning

confidence: 99%

“…A meta-analysis [141] and some reviews [139,142] concluded to positive effects while looking to intensive short-time (1-4 min) exercises. The same positive effect was obtained in young athletes submitted to plyometric exercises (45 vertical jumps) following ß-alanine supplementation (5 g per day) during a period of 2 months [143].…”

Section: A) Classical Protein Feedingmentioning

confidence: 99%

Protein metabolism and physical training: any need for amino acid supplementation?

Poortmans

Carpentier

2016

Nutrire

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Muscle mass is the major deposit of protein molecules with dynamic turnover between net protein synthesis and degradation. In human subjects, invasive and non-invasive techniques have been applied to determine their skeletal muscle catabolism of amino acids at rest, during and after different forms of physical exercise and training. The aim of this review is to analyse the turnover flux and the relative oxidation rate of different types of muscle proteins after one bout of exercise as well as after resistance and endurance condition of training. Protein feeding in athletes appears to be a crucial nutrition necessity to promote the maintenance of muscle mass and its adaptation to the need imposed by the imposed technical requirements. In resting human individuals, the recommended protein daily allowance is about 0.8 g (dry weight) kg −1 body weight per 24 h knowing that humans are unable to accumulate protein stores in muscle tissues. Nevertheless, practical feeding recommendations related to regular exercise practice are proposed to athletes by different bodies in order to foster their skills and performance. This review will examine the results obtained under endurance and resistance type of exercise while consuming single or repeated doses of various ingestions of protein products (full meat, essential amino acids, specific amino acids and derivatives, vegetarian food). From the scientific literature, it appears that healthy athletes (and heavy workers) should have a common diet of 1.25 g kg −1 24 h to compensate the exercise training muscle protein degradation and their resynthesis within the following hours. A nitrogen-balance assay would be recommended to avoid any excessive intake of protein. Eventually, a daily equilibrated food intake would be of primer importance versus inadequate absorption of some specific by-products.

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Synthesis of β-alanine from l-aspartate using l-aspartate-α-decarboxylase from Corynebacterium glutamicum

Yan¹,

Zhao²,

Li³

et al. 2014

Biotechnol Lett

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β-Alanine is mainly produced by chemical methods in current industrial processes. Here, panD from Corynebacterium glutamicum encoding L-aspartate-α-decarboxylase (ADC) was cloned and expressed in Escherichia coli BL21(DE3). ADC C.g catalyzes the α-decarboxylation of L-aspartate to β-alanine. The purified ADC C.g was optimal at 55 °C and pH 6 with excellent stability at 16-37 °C and pH 4-7. A pH-stat directed, fed-batch feeding strategy was developed for enzymatic synthesis of β-alanine to keep the pH value within 6-7.2 and thus attenuate substrate inhibition. A maximum conversion of 97.2 % was obtained with an initial 5 g L-aspartate/l and another three feedings of 0.5 % (w/v) L-aspartate at 8 h intervals. The final β-alanine concentration was 12.85 g/l after 36 h. This is the first study concerning the enzymatic production of β-alanine by using ADC.

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Use of β-Alanine as an Ergogenic Aid

Cited by 3 publications

References 15 publications

The Effect of β-Alanine Supplementation on Performance, Cognitive Function and Resiliency in Soldiers

The Effect of β-Alanine Supplementation on Performance, Cognitive Function and Resiliency in Soldiers

Protein metabolism and physical training: any need for amino acid supplementation?

Synthesis of β-alanine from l-aspartate using l-aspartate-α-decarboxylase from Corynebacterium glutamicum

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