Use of α-tocopherol emulsion for antioxidant protection of ischemic or stored kidneys

Abstract

The ability of cc-tocopherol in the form of an emulsion to augment the antioxidant reserve of kidneys during their ischemia or storage is explored. Over 10 min after an intravenous injection of the emulsion into rats or rabbits at 10 mg/kg body weight, the mean a-tocopherol concentration in the renal cortical layer rose from 6.7+0.2 to 7.4+0.2 gg/g (p<0.05); the injection also slowed the accumulation of malonic dialdehyde in cortical layer homogenates of intact and ischemic kidneys during ascorbate-induced lipid peroxidation. In kidneys stored at 4~ in a preservative solution to which the a-tocopherol emulsion had been added (10 mg/liter), lipid peroxidation was found to be inhibited after 24 and 48 h of storage.