Use of Yeast Lysate in Women with Recurrent Vulvovaginal Candidiasis

Abstract

Vulvovaginal candidiasis (VVC) affects a significant number of women, especially in working age. In an estimated 75% of women an episode of acute vulvovaginal candidiasis occurs during lifetime and another 5 -10% of women develop recurrent vulvovaginal candidiasis (RVVC). This is mainly characterized by intense burning, itching, pain, abnormal discharge, dyspareunia. Immune response to candidiasis is both cellular (CMI) (natural protection mechanisms) and humoral (antibody production). Understanding the principles of immunity in candidiasis is also important for development of candida vaccines. CANDIVAC contains lyophilized Candida lysate (C. albicans, C. krusei, C. glabrata) together with immunostimulatory bacterial strain of Propionibacterium acnes. The product is taken orally in capsules for 10 days followed by a 20-day pause. It is administered for 3 to 6 months. The product has been tested in a total of 75 women at the age of 18 -45 years. In these women at least 4 episodes of vulvovaginal candidiasis have been microscopically or laboratory diagnosed during the last 12 months. Following CANDIVAC administration, statistically significant changes occurred in the evaluation of subjective and some objective criteria. The most important marker of product efficiency is a significant reduction in recurrence compared to the recent state. This criterion has a fundamental importance in patient satisfaction. Before medication the patients suffered from at least 4 attacks, while after medication an attack occurred in only 31% of women and more than 2 attacks in only 3% of treated women. Compromised balance of immune system plays a major role in recurrent vulvovaginal candidiasis. Specific oral product CANDIVAC, prepared from the most common strains of yeast infections, supports immune mechanisms, ensuring resistance of the human organism against yeasts. Its administration significantly prolongs remission, leads to a reduction in application of antimycotics and also changes properties of cellular and humoral immunity in medicated patients.

Conformationally modulated immunogenic proteins in homeopathic medicines: Does protein-based mucosal immunotherapy have the potential to treat diverse diseases?

“…In addition to their predominant use in the treatment of respiratory tract disorders like asthma, COPD and rhinitis, bacterial lysates have shown encouraging results in the treatment of various diseases like diverticulitis, rheumatoid arthritis, type 1 diabetes, inflammatory bowel disease, urinary tract infections, periodontitis, relapse of tuberculosis and food allergy [16][17][18][19][20][21][22]. Bacterial lysates are also effective against fungal and viral infections [23][24][25][26]. Interestingly, fungal lysates like bacterial lysates contain many immunogenic proteins, though a few studies on their role as immunostimulants have been reported so far [23,24,27].…”

“…Bacterial lysates are also effective against fungal and viral infections [23][24][25][26]. Interestingly, fungal lysates like bacterial lysates contain many immunogenic proteins, though a few studies on their role as immunostimulants have been reported so far [23,24,27].…”

“…Microbial lysates being a mixture of bacterial and fungal lysates are expected to show immunostimulating/immunomodulating actions similar to those of bacterial lysates [16-22, 25, 26] augmented by a contribution from the fungal lysates, though, as stated earlier, a little is known about the immunomodulating characteristics of fungal lysates [23,24]. Most of the studies on bacterial lysates are limited to their prophylactic use [16-22, 25, 26], though they are quite effective in the management of acute episodes too [36,37].…”

“…Two major issues plague homeopathy and portray it as a fringe science. First, as dictated by the Avogadro's number (6.023 x 10 23 ), above a particular dilution (12C or 24X, equivalent dilution 1 in 10 24 , C and X are the centesimal and decimal scales of dilution, respectively), the probability of getting a drug molecule in the diluted medicines goes down dramatically and at dilutions of 30C (1 in 10 60 ) and above, the probability turns out to be vanishingly small and, for all practical purposes, equals zero [1][2][3]. Accordingly, homeopathic medicines diluted beyond the so-called 'Avogadro's limit' (designated as ultra-diluted) should be devoid of any drug molecule and, hence, unlikely to cure any disease.…”

IMMUNOBIOLOGICAL EFFECTS OF MARINE Debaryomyces Hansenii-DERIVED LYSATES ON GOAT PERIPHERAL BLOOD LEUKOCYTES

“…The authors showed that live yeast and βglucans were able to modulate the immune system by promoting cell viability, phagocytic activity, antioxidant immune response, immune-related gene expression, and induction of trained immunity in goat peripheral blood leukocytes and newborn goats (Medina-Córdova et al, 2018;Angulo et al, 2018;Angulo et al, 2019;Angulo et al, 2020). Remarkably, Vrzal et al (2015) reported that administrating a patented commercial immunostimulant product based on Candida albicans, C. krusei, C. glabrata, and Propionibacterium acnes lysates prolonged the relapse period of vulvovaginal affections and had a positive effect on cellular immunity qualities in women. Therefore, this study was designed to evaluate the immunostimulant activity of lysates derived from five marine yeast D. hansenii strains in goat peripheral blood leukocytes using in vitro assays.…”