Use of xanthan and its binary blends with synthetic polymers to design controlled release formulations of buccoadhesive nystatin tablets

Abstract

Various buccoadhesive nystatin tablets formulations containing xanthan, carbopols (934P, 971P, 974P), PVP K30 or PEG 6000 or their binary blends were prepared. The powders were compressed into tablets at a constant compression pressure. Drug release behaviour, swelling and erosion indices and strength of bioadhesion in vitro to a biological membrane were investigated. The interaction between nystatin and polymers was investigated by DSC and FT-IR. Tablets containing the different types of carbopol alone consistently showed an initial burst release of drug, whereas this was not observed for matrices containing xanthan or xanthan-carbopol. The presence of PEG in xanthan-containing formulations induced an increase in dissolution rate; however, in the absence of xanthan the amount of drug release from a PEG matrix was reduced to < 15% over 8 h dissolution. The presence of PVP increased the dissolution rate of nystatin due to the relative hydrophilicity of PVP. The presence of calcium ions induced a more rigid gel in the xanthan matrix as a result of interaction between the polymer and calcium ions. Xanthan can be used in potential mucoadhesive formulations containing nystatin to produce a controlled release of the drug and the outcomes of this work may provide a suitable strategy for matrix selection to provide more efficacious treatment alternatives for candidiasis and other disease processes for significant patient populations.

Enhancement of dissolution of nystatin from buccoadhesive tablets containing various surfactants and a solid dispersion formulation

“…11). The figure shows that the original nystatin showed a few small peaks, ones that started to appear above 100 o C. As nystatin does not melt, these peaks could be due to a gradual decomposition of nystatin as has been reported previously (Sakeer et al 2010). Lactose showed two endothermic peaks at 148 and 219 o C. The first endothermic peak corresponds to the dehydration of crystallization water; the second endothermic peak coincides with the melting of a lactose monohydrate.…”

Formulation Optimization and <i>In-vitro</i> Evaluation of Oral Floating Captopril Matrix Tablets using Factorial Design

“…Previous studies revealed important economical and pharmaceutical advantages of xanthan gum over other polymers [20]. The natural gum possess properties of reduced burst initial release as well as more reproducible and predictable drug release possibly following zero order kinetics [21].…”