Use of warm Ringer’s lactate solution in the management of locally advanced giant cell tumor of bone

Waikakul, Saranatra; Asavamongkolkul, Apichat; Phimolsarnti, Rapin

doi:10.1007/s10147-015-0856-x

Cited by 6 publications

(8 citation statements)

References 29 publications

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“…4), hemangiomas, and GCTs. Sclerosing agents include ethanol, denosumab, doxycycline, polidocanol, sodium tetradecyl sulfate (STS), and hydrogen peroxide, 40 as well as warm Ringer's lactate solution, 40 phenol, or liquid nitrogen. STS and doxycycline can be delivered as foam, for improved coverage and dissemination within the tumor cavity, with reduced side effects from foam leakage when compared with fluids, and they are therefore preferred over other sclerosants.…”

Section: Applicationsmentioning

confidence: 99%

“…38 • Aggressive tumors: As adjuvant therapy to treat locally advanced giant cell bone tumors. 40 Surgery en bloc remains the treatment of choice for secondary ABCs and malignant cystic tumors (primary and metastatic).…”

Section: Applicationsmentioning

confidence: 99%

“…Advantages: Warm Ringer's lactate heated to 50°C combined with thermoablation techniques was shown to achieve maximal GCT cellular toxicity with minimal chondrocyte and osseous toxicity, in addition to minimal endothelial vascular damage. 40 Complications: Complication rates are low and include iatrogenic fractures, thrombosis, embolism, infection, hemorrhage, neurovascular damage, and skin necrosis. 36…”

Section: Applicationsmentioning

confidence: 99%

“…Histologically, normal cells have the ability to produce heat shock proteins that can protect them from heat-induced apoptosis but is not expressed in tumor cells. 40 This can be achieved by introducing core temperature changes to tumors of up to 45 to 95°C with thermoablation of À 45 to À 160°C with cryoablation (CA). Subsequent to ablation, the body heals with involution of the ablation zone over weeks to months in case of soft tissue tumors, 15 and with partial or complete bone filling and sclerosis in bone tumors (►Figs.…”

Section: Mode Of Therapymentioning

confidence: 99%

See 3 more Smart Citations

Interventional Techniques for Bone and Musculoskeletal Soft Tissue Tumors: Current Practices and Future Directions - Part I. Ablation

Dalili

Isaac

Bazzocchi

et al. 2020

Semin Musculoskelet Radiol

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Musculoskeletal (MSK) image-guided oncologic intervention is an established field within radiology. Numerous studies have described its clinical benefits, safety, cost effectiveness, patient satisfaction, and improved quality of life, thereby establishing image-guided oncologic intervention as a preferred pathway in treating patients presenting with specific benign MSK tumors. But there is a paradigm shift on the horizon because these techniques may also support established pillars (surgery, systemic treatment, radiotherapy) in the treatment of malignant MSK tumors. Unlike benign tumors, where they are used as primary therapy lines with curative intent, such interventions can be selected for malignant tumors as adjuvant treatment in painful or unstable bone or soft tissue lesions or as more palliative therapy strategies. Using examples from our clinical practices, we elaborate on the benefits of applying a multidisciplinary approach (traditionally involving MSK radiologists, oncologists, orthopaedic surgeons, microbiologists, pathologists, physiotherapists, and pain management experts), ideally within a sarcoma treatment center to deliver a patient-specific therapy plan and illustrate methods to assess the benefits of this model of care.In this article, we review the current repertoire of ablation techniques, demonstrate why such procedures offer value-based alternatives to conventional treatments of specific tumors, and reflect on future directions. Additionally, we review the advantages and limitations of each technique and offer guidance to improve outcomes.

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Section: Applicationsmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

Section: Mode Of Therapymentioning

confidence: 99%

See 2 more Smart Citations

Interventional Techniques for Bone and Musculoskeletal Soft Tissue Tumors: Current Practices and Future Directions - Part I. Ablation

Dalili

Isaac

Bazzocchi

et al. 2020

Semin Musculoskelet Radiol

View full text Add to dashboard Cite

show abstract

“…The recurrence rate is approximately 17.4% within the rst ve years of follow-up [8]. Intralesional curettage with the subsequent application of different adjuvant substances to control local recurrence of GCT of bone have been studied, including warm Ringer's lactate solution, phenol, bone cement, zoledronic acid-loaded bone cement, and liquid nitrogen [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Chromosomal Abnormalities Associated With Local Recurrence or Pulmonary Metastasis of Giant Cell Tumor of Bone in Thai Adults: A Prospective Cohort Study With 6 Years of Follow-Up

Ruangsomboon

Heepchantree

Reingrittha

et al. 2021

Preprint

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Background: Giant cell tumor (GCT) of bone demonstrates chromosomal abnormalities. This study aimed to investigate the prognostic role of chromosomal abnormalities of primary GCT of bone relative to local recurrence or pulmonary metastasis.Methods: This prospective longitudinal cohort study with 6 years of follow-up included consecutive patients with primary GCT of bone that were surgically treated during 2011 to 2013 at the Department of Orthopaedic Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. All patients underwent surgical resection with extended intralesional curettage and phenol local adjuvant therapy. Systematic cytogenetic analysis compared cytogenetic abnormalities between patients with and without local recurrence or pulmonary metastasis. Fifteen patients were eligible, enrolled, and had successful cytogenetic analysis.Results: The median follow-up time was 46 months (interquartile range [IQR]: 32-58). Five patients experienced local recurrence or pulmonary metastasis with a median time to recurrence of 6 months (IQR: 3.25-10.5). The mean number of abnormal cells in the primary culture compared between those with local recurrence or pulmonary metastasis and those without was 24.4 vs. 9.6 cells, respectively (p=0.04). A similar pattern was observed in the cultures of the subsequent four passages (all p<0.05). Forty-five patterns of clonal telomeric association (tas) were observed in passaged cultures. Six tas patterns were associated with local recurrence or pulmonary metastasis, including tas(11;19)(p15;q13.4), tas(15;19)(q26.3;q13.4), tas(15;22)(p13;p13), tas(16;19)(p13.3;q13.4), tas(17;19)(p13;q13.4), and tas(19;22)(q13.4;q13).Conclusions: The mean number of abnormal cells and the six identified TAS patterns may be valuable prognostic factors for local recurrence or pulmonary metastasis of GCT tumor of bone.

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Interventional Techniques for Bone and Musculoskeletal Soft Tissue Tumors: Current Practices and Future Directions – Part II. Stabilization

Dalili

Isaac

Cazzato

et al. 2020

Semin Musculoskelet Radiol

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Percutaneous image-guided oncologic interventions have rapidly evolved over the last two decades as an independent strategy or used within a first-, second-, or even third-line strategy in the treatment of musculoskeletal (MSK) tumors. Abundant mostly nonrandomized publications have described the safety, efficacy, and reproducibility of implementing percutaneous therapies both with curative and palliative intent. In this article, we continue to share our experience in bone and MSK soft tissue interventions focusing on stabilization and combined ablation and stabilization. We propose a pathway and explore future directions of image-guided interventional oncology related to skeletal disease. We reflect on the advantages and limitations of each technique and offer guidance and pearls to improve outcomes. Representing patterns from our practices, we demonstrate the role of collaborative working within a multidisciplinary team, ideally within a dedicated tumor treatment center, to deliver patient-specific therapy plans that are value based and favored by patients when given the choice.

show abstract

Use of warm Ringer’s lactate solution in the management of locally advanced giant cell tumor of bone

Cited by 6 publications

References 29 publications

Interventional Techniques for Bone and Musculoskeletal Soft Tissue Tumors: Current Practices and Future Directions - Part I. Ablation

Interventional Techniques for Bone and Musculoskeletal Soft Tissue Tumors: Current Practices and Future Directions - Part I. Ablation

Chromosomal Abnormalities Associated With Local Recurrence or Pulmonary Metastasis of Giant Cell Tumor of Bone in Thai Adults: A Prospective Cohort Study With 6 Years of Follow-Up

Interventional Techniques for Bone and Musculoskeletal Soft Tissue Tumors: Current Practices and Future Directions – Part II. Stabilization

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