Use of Vivostat PRF® in Acanthamoeba keratitis

Marín-Payá, Emma; Rahhal-Ortuño, Miriam; Aguilar-González, Marina; Fernández-Santodomingo, A.S.; García-Delpech, S.

doi:10.22336/rjo.2020.37

Cited by 1 publication

(2 citation statements)

References 4 publications

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“…In the present study, complications such as pigmentation and anterior synechia were observed in the PRF gel group, which is consistent with findings from other human studies 47 , 48 . However, the use of homologous L-PRF membrane proved effective in sealing severe corneal ulcers, including grade III ulcers with or without perforations and staphyloma 44 .…”

Section: Discussionsupporting

confidence: 93%

“…The inflammatory response following alkali combustion was quantified by area measurements of re-epithelialization and neovascularization 61 . Corneal wound healing is a complex process involving various factors, including proteinases, growth factors, cytokines, and lacrimal glands 62 – 64 While PRF has been used to treat corneal ulcers and has shown potential benefits, other studies have reported adverse effects on ulcer healing 43 , 47 , 48 . In this study, A-PRF gel was directly applied to the ocular surface, which has been found to prevent dehydration 65 .…”

Section: Discussionmentioning

confidence: 99%

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Advanced platelet-rich fibrin promotes healing of induced corneal ulcer in donkeys (Equus asinus)

Hosny,

Abd-Elkareem,

Ali

et al. 2023

Sci Rep

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Ulcerative keratitis is a common disease in horses which may cause blindness. To prevent secondary bacterial and fungal infections and promote quick re-growth of the epithelial layer, different treatment approaches have been employed. This study aimed to examine the effects of advanced platelet-rich fibrin (A-PRF) gel on the healing process of experimentally induced corneal ulcers in donkeys. Nine healthy adult donkeys were used for the study. The donkeys were divided into two groups: the control group, where no medication was applied to the corneal ulcer, and the A-PRF gel group, where A-PRF gel was applied once a day on specific days after ulcer induction. The healing process was evaluated through various examinations and analyses. The results demonstrated that the A-PRF gel group showed significant improvement in the corneal ulcer area, with epithelial and stromal regeneration. At day 35, about 60% of the A-PRF group showed negative fluorescein uptake. Additionally, fewer complications were observed during the healing process compared to the control group. In conclusion, A-PRF gel is an important and safe therapeutic option for controlling ocular surface infection and promoting corneal healing. We recommend using A-PRF gel as an alternative approach, avoiding eyelid suturing, and minimizing corneal irritation.

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Section: Discussionsupporting

confidence: 93%