“…Satisfactory c1inical responses have been reported in common skin diseases such as acne vu1caris (Davidson and Sobel,1949), sorne eczemas (Gross,1941;Stroesser and Eelson,1952) and psoriasis (Schwartz,1950), as ·nell as in ether disorders ctaracterized chief1y ~' fo11icu1ar hyperkeratosis (Spies, 1947), Sorne patients ni th rare familial diseases such as Darier 1 s disease (keratosis follicularis), Devergie 1 s disease (pityriasis rubra pi1aris) and ichthyosis have a1so responded favourably to vitamin A therapy (Lei tner and l.ioore, 1048;Lei tner, 194 7;Keddie, 1948; Ra pa port et a1,1942), Law serum 1eve1s of vitamin A h2ve been reported in sorne dermato1ozic patients (Chieffi and Kirk,l949;Leitner,1947;Lahiri and Scandrett,l954). The increased blood levels that follm·ied int~msive vitanin .A therapy, hor1ever, were not always corre1ated with clinical responses in the same patients (Leitner and Loore,l<;L;C; Cornble )t,l954), In psM.ents '>'lith Darier 1 s disease or pityriasis rubra it bas been reported that liver function is impaired (Leitner :::nd t:oore,l948; Leitner, 1947;Keddie ,194[;).…”