1948
DOI: 10.1001/archderm.1948.01520200067009
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Use of Vitamin a in the Treatment of Cutaneous Diseases

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Cited by 19 publications
(4 citation statements)
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References 31 publications
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“…I) has long been known for its importance in promoting general growth, in regulating proliferation and differentiation of epithelial tissues and in maintaining visual function and reproduction. Retinol (vitamin A) was introduced for the treatment of various skin diseases more than 40 years ago (Keddie 1948). Because oral therapy with retinol was associated with toxicity, including fatigue, headache, cheilitis, anorexia, peeling of the skin, pseudotumour cerebri, papillary oedema, hepatotoxicity, skeletal changes and lipid abnormalities (Korner & Vollum 1975), the use of retinol as an orally administered drug declined.…”
Section: Discussionmentioning
confidence: 99%
“…I) has long been known for its importance in promoting general growth, in regulating proliferation and differentiation of epithelial tissues and in maintaining visual function and reproduction. Retinol (vitamin A) was introduced for the treatment of various skin diseases more than 40 years ago (Keddie 1948). Because oral therapy with retinol was associated with toxicity, including fatigue, headache, cheilitis, anorexia, peeling of the skin, pseudotumour cerebri, papillary oedema, hepatotoxicity, skeletal changes and lipid abnormalities (Korner & Vollum 1975), the use of retinol as an orally administered drug declined.…”
Section: Discussionmentioning
confidence: 99%
“…The hypervitaminosis A syndrome (STRAUMFJORD 1942;KEDDIE 1948) and its resemblance to various dermatoses was the reason for the therapeutic application of vitamin A and later of all-trans retinoic acid (FRY and SCHOCH 1952;BEER 1962;SnJTTGEN 1962;FULTON et al 1968;FROST and WEINSTEIN 1969;KLIGMAN et al 1969;FRY et al 1970;BOLLAG and OTT 1971;ORFANOS et al 1973). Compared with vitamin A, all-trans-retinoic acid proved to be highly efficient in patients with acne, psoriasis, genodermatoses, actinic keratoses, and basaliomas.…”
Section: A General Aspectsmentioning
confidence: 99%
“…Satisfactory c1inical responses have been reported in common skin diseases such as acne vu1caris (Davidson and Sobel,1949), sorne eczemas (Gross,1941;Stroesser and Eelson,1952) and psoriasis (Schwartz,1950), as ·nell as in ether disorders ctaracterized chief1y ~' fo11icu1ar hyperkeratosis (Spies, 1947), Sorne patients ni th rare familial diseases such as Darier 1 s disease (keratosis follicularis), Devergie 1 s disease (pityriasis rubra pi1aris) and ichthyosis have a1so responded favourably to vitamin A therapy (Lei tner and l.ioore, 1048;Lei tner, 194 7;Keddie, 1948; Ra pa port et a1,1942), Law serum 1eve1s of vitamin A h2ve been reported in sorne dermato1ozic patients (Chieffi and Kirk,l949;Leitner,1947;Lahiri and Scandrett,l954). The increased blood levels that follm·ied int~msive vitanin .A therapy, hor1ever, were not always corre1ated with clinical responses in the same patients (Leitner and Loore,l<;L;C; Cornble )t,l954), In psM.ents '>'lith Darier 1 s disease or pityriasis rubra it bas been reported that liver function is impaired (Leitner :::nd t:oore,l948; Leitner, 1947;Keddie ,194[;).…”
Section: B Clinical Use Of Vitamin a In Dermatologymentioning
confidence: 99%