Use of viscoelastic substance in ophthalmic surgery — focus on sodium hyaluronate

Abstract

Among viscoelastic substances, sodium hyaluronate has become the most popular for intraocular surgeries since the introduction of Healon® (sodium hyaluronate 1%, 4 × 106 daltons) in 1979. This review focuses on the recent development of a new generation of sodium hyaluronate agents with new rheologic properties and the relevant new techniques used in cataract, glaucoma, corneal, and vitreoretinal surgeries. The introduction of sodium hyaluronate agents with different rheologic properties has improved the safety and reliability of intraocular surgeries. Although there have been numerous studies reporting the effectiveness of viscoelastic substances in intraocular surgeries, rigorous validation by multi-center randomized control trials is lacking in many cases. At present, no single viscoelastic agent is most suitable to all of the various intraocular surgical techniques. Therefore, ophthalmologic surgeons should keep up with recent developments of viscoelastic agents and relevant surgical techniques for better patient care.

Ingested hyaluronan moisturizes dry skin

“…In the field of medicine, high MW HA (approximately millions) is utilized to treat degenerative joint conditions because it has high viscosity and water retention; furthermore, it is used as an adjuvant treatment in cataract surgery [32-34]. Recently, as a treatment for facial lines and wrinkles, HA fillers in cosmetic surgery were used in the world.…”

A Crosslinked HA-Based Hydrogel Ameliorates Dry Eye Symptoms in Dogs

“…Additionally, the concentration of ions, such as salts, in the solution may influence the rheologic properties due to the polyanionic nature of HA [16, 17]. Several HA-based products with varying rheologic properties have been developed for ophthalmic surgery [18, 19], and these properties may influence comfort and efficacy in a dry eye formulation [14]. …”

Hyaluronsäuregele zur Druckregulierung in der Glaukomtherapie

“…B. als viskoelastischer Körper-oder Weichgewebeersatz, als Trägermaterial für Arzneimittelfreisetzung, als Füllstoff für Gewebe, als Haut-und Gewebeschutz oder zur Gewebetrennung verwendet [14,23]. Auch in der Glaukombehandlung kommt die HA bereits bei chirurgischen Eingriffen zum Einsatz [11,28].…”