USE OF VENOUS BLOOD FOR pH AND CARBON-DIOXIDE STUDIES

Brooks, David K.; Wynn, V.

doi:10.1016/s0140-6736(59)90053-4

Cited by 67 publications

(37 citation statements)

References 6 publications

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“…Previous studies have shown an excellent correlation of arterial and venous pH values in the laboratory and various clinical settings. [10][11][12][13][14] Also, a technical review on the management of DKA allowed for venous pH values to be substituted for arterial pH values at the clinician's discretion in the initial evaluation of children but not in adults. 1 A previous ED-based study showed excellent correlation (r ¼ 0.969, r 2 ¼ 0.939) between venous and arterial samples for pH determination specifically in adult patients determined to have DKA.…”

Section: Discussionmentioning

confidence: 99%

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Arterial Blood Gas Results Rarely Influence Emergency Physician Management of Patients with Suspected Diabetic Ketoacidosis

2003

Academic Emergency Medicine

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Objectives: To test the hypothesis that arterial blood gas (ABG) results for patients with suspected diabetic ketoacidosis (DKA) do not influence emergency physicians' management decisions and to assess correlation and precision between venous pH and arterial pH. Methods: Prospective, observational study of emergency physicians' decision making for consecutive ED patients with suspected DKA. Inclusion criteria were capillary blood glucose equal to or greater than 200 mg/dL, ketonuria, and clinical signs and symptoms of DKA. Venous pH, chemistry panel, and ABGs were drawn before treatment. Attending emergency physicians indicated planned management and disposition on a standardized form before and after reviewing ABG and venous pH results. This study was powered to detect a 10% difference in management decisions (n ¼ 195). Pearson's correlation and Bland-Altman bias plot were used to compare venous pH and arterial pH. Results: ABG analysis changed the emergency physicians' diagnosis in 2/200 cases (1.0%; 95% confidence interval [95% CI] ¼ 0.3% to 3.6%), altered treatment in 7/200 cases (3.5%; 95% CI ¼ 1.7% to 7.1%), and changed disposition in 2/200 cases (1.0%; 95% CI ¼ 0.3% to 3.6%). The pH value of the ABGs changed the treatment or disposition in 5/200 patients (2.5%; 95% CI ¼ 1.1% to 5.7%). The Po 2 and Pco 2 results of the ABGs altered treatment and disposition in 2/200 patients (1.0%; 95% CI ¼ 0.3% to 3.6%). Venous pH correlated well with arterial pH (r ¼ 0.951), and bias plotting yielded a bias value of ÿ0.015 (6 0.006 pH units). Conclusions: ABG results rarely influenced emergency physicians' decisions on diagnosis, treatment, or disposition in suspected DKA patients. Venous pH correlated well and was precise enough with arterial pH to serve as a substitute.

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Section: Discussionmentioning

confidence: 99%

“…1,2 Venous pH sampling has been proposed as an alternative to ABG sampling. [10][11][12][13] Venous pH has been shown to correlate well with arterial pH in the diagnostic evaluation of patients with DKA. 14 It is possible that ABG data might not be required by physicians who manage patients with suspected DKA.…”

mentioning

confidence: 96%

Arterial Blood Gas Results Rarely Influence Emergency Physician Management of Patients with Suspected Diabetic Ketoacidosis

2003

Academic Emergency Medicine

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“…It has been shown that under these conditions, the venous PCO2 closely approximates systemic arterial PCO2 ( Brooks and Wynn, 1959). Blood pressure was monitored repeatedly throughout the procedure by a standard sphygmomanometer cuff.…”

Section: Methodsmentioning

confidence: 99%

Effect of tinofedrine (Homburg D8955) on cerebral blood flow in multi-infarct dementia.

Merory¹,

Boulay²,

Marshall³

et al. 1978

Journal of Neurology, Neurosurgery & Psychiatry

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“…A table (Leitner and Thaler, 1960) was employed for calculating the arterial or umbilical venous Pco2 from the pH and total CO2 content of arterial or arterialized blood (Brooks and Wynn, 1959;Gambino, 1961) and the pH and total CO2 content of the umbilical venous blood. The arterialized blood was collected by an anaerobic technique (Lilienthal and Riley, 1944;Gambino, 1961).…”

Section: Comparison Of Mixed Venous Pco2 and Blood Pcomentioning

confidence: 99%