Use of various vegetable oils in designing photoprotective nanostructured formulations for UV protection and antioxidant activity

The aim of this work was to evaluate the effect of Ouratea sp. butter (OB) on crystallinity of solid lipids used in nanostructured lipid carriers systems. Firstly, the composition of fatty acids in OB was evaluated by transesterification reaction for gas chromatography fatty acid methyl ester analysis. The solid lipids such as stearic acid (SA), beeswax (BW) and carnauba wax (CW) were submitted to recrystallization process (heating-cooling). Moreover, binary mixtures between solid lipids and OB were prepared in ratio 1:1 (w/w) by heating of the components above the melting point followed by cooling at room temperature. Thus, the samples were characterized by differential scanning calorimetry (DSC), thermogravimetry (TG), X ray diffraction (XRD) and hot-stage polarized optical microscopy (HSPOM). DSC curves showed a shift of the melting point to lower temperatures in the lipid mixtures with OB. TG data suggested a thermal stability reduction in the lipid mixtures containing SA and CW and an increase thermal stability in the mixture containing BW. XRD data confirmed DSC results, showing a reduction in intensity of main diffraction peaks of the lipid mixtures and a presence of the amorphous portion in angle 2h: 22°. Finally, HSPOM demonstrated that the microstructures of solid lipids decreased in size and thickness in the mixtures containing OB at room temperature and slightly before the melting point, confirming previous characterizations. These results suggest that lipid mixtures with OB present a lower crystallinity, and it is expected that amorphous portion facilitates drug incorporation, for example.

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“…In addition, vegetable oils and fats such as Ouratea sp. butter have recently been investigated in nanostructured formulations [4].…”

Section: Introductionmentioning

confidence: 99%

Effect of Ouratea sp. butter in the crystallinity of solid lipids used in nanostructured lipid carriers (NLCs)

Galvão

Trindade

Santos

et al. 2015

J Therm Anal Calorim

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“…The aforementioned products prevent skin aging due to oxidative stress and premature aging. [69][70][71][72][73] The combination of polyphenols with retinols enhances skin protection. Other than nanosizing, few delivery systems have been used to develop nanoantiaging creams and lotions for the enhanced activity of bioactive compounds to deeper layers of skin.…”

Section: Phytoconstituent-based Nanocosmeceuticals For Skin Therapy Nmentioning

confidence: 99%

“…92 Even though phytobioactive compounds show increased sunscreen effects, their stability and skin protective effects were greatly enhanced by using nanotechnology delivery systems in the sunscreen cream and lotions. 73,93,94 Recently, saffranol was constructed using solid lipid nanoparticles and had enhanced sun screening activity in the size range of 103-233 nm. 80 Similarly, nanostructured lipid carriers were constructed using rice bran oil and raspberry oil and had enhanced sunscreen activities with higher antioxidant and UV protective activities.…”

Section: Nanosunscreensmentioning

confidence: 99%

Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy

Ganesan¹,

Choi²

2016

IJN

123

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Phytocompounds have been used in cosmeceuticals for decades and have shown potential for beauty applications, including sunscreen, moisturizing and antiaging, and skin-based therapy. The major concerns in the usage of phyto-based cosmeceuticals are lower penetration and high compound instability of various cosmetic products for sustained and enhanced compound delivery to the beauty-based skin therapy. To overcome these disadvantages, nanosized delivery technologies are currently in use for sustained and enhanced delivery of phyto-derived bioactive compounds in cosmeceutical sectors and products. Nanosizing of phytocompounds enhances the aseptic feel in various cosmeceutical products with sustained delivery and enhanced skin protecting activities. Solid lipid nanoparticles, transfersomes, ethosomes, nanostructured lipid carriers, fullerenes, and carbon nanotubes are some of the emerging nanotechnologies currently in use for their enhanced delivery of phytocompounds in skin care. Aloe vera , curcumin, resveratrol, quercetin, vitamins C and E, genistein, and green tea catechins were successfully nanosized using various delivery technologies and incorporated in various gels, lotions, and creams for skin, lip, and hair care for their sustained effects. However, certain delivery agents such as carbon nanotubes need to be studied for their roles in toxicity. This review broadly focuses on the usage of phytocompounds in various cosmeceutical products, nanodelivery technologies used in the delivery of phytocompounds to various cosmeceuticals, and various nanosized phytocompounds used in the development of novel nanocosmeceuticals to enhance skin-based therapy.

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“…In the cosmetic industry, vegetable oils extracted mainly from the seeds of plants and fruits are considered important raw materials for the development of ecological cosmetics. Cosmetic products based on vegetable oils help protect the skin from excessive fluid loss, allow skin respiration and assimilate sunlight (1). The oil extracted from Babassu (Orbignya phalerata Martius) coconut almonds has generated interest in the cosmetics industry, becoming a major candidate for application in cosmetic products, mainly for topical use (2)(3)(4).…”

Section: Introductionmentioning

confidence: 99%

“…Na indústria cosmética, os óleos vegetais extraídos principalmente das sementes de plantas e frutas, são considerados matérias-primas importantes para o desenvolvimento de cosméticos ecológicos. Produtos cosméticos à base de óleos vegetais ajudam a proteger a pele da perda excessiva de fluidos, permitem a respiração da pele e assimilam a luz solar (1). O óleo extraído das amên-doas do coco de Babaçu (Orbignya phalerata Martius) gerou interesse na indústria cosmética, tornando-se um importante candidato para aplicação em produtos cosméticos, principalmente para uso tópico (2)(3)(4).…”

Section: Introductionunclassified

Development and in vivo evaluation of the moisturising potential of cosmetic formulations containing Babassu (Orbignya phalerata Martius) oily extract

Vieira¹,

Sales²,

Cerqueira-Coutinho³

et al. 2017

BBR

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Biomedical and Biopharmaceutical Research J o r n a l d e I n v e s t i g a ç ã o B i o m é d i c a e B i o f a r m a c ê u t i c a Development and in vivo evaluation of the moisturising potential of cosmetic formulations containing Babassu (Orbignya phalerata Martius) oily extract AbstractThe objective of this study was to use oily extracts of the species Orbignya phalerata Martius (Babassu) from three ecological regions in Maranhão state, Brazil: Forest (BBF), Coast (BBC) and Lowlands (BBL) to develop cosmetic formulations. Formulations with 10 wt% of Babassu oily extracts were characterised regarding their stability for 30 days (separation of phases after centrifugation, pH, density, viscosity and droplets size distribution) and evaluation of efficacy in vivo by cutaneous biometry. Results indicated that the formulations were physically stable and presented pseudo-plastic fluid behavior as evaluated by rheology. Concerning the in vivo efficacy assays, the formulation containing BBL increased the hydration of the volunteers'skin when compared to a formulation containing only a commercial standard moisturising ingredient, without altering the skin pH. BBL showed to be a promising ingredient to cosmetics, behaving as an excellent moisturiser likely because it contains the highest amounts of lauric, myristic and oleic acids that present great emollient potential.Keywords: Cosmetic formulations, cutaneous biometry, in vivo evaluation of moisturising effect, Orbignya phalerata Martius, vegetal oily extract. ResumoO objetivo deste estudo foi utilizar extratos oleosos da espécie Orbignya phalerata Martius (Babaçu) de três regiões ecológicas do Estado do Maranhão (Brasil): Mata dos Cocais (BBF), Litoral (BBC) e Baixada Maranhense (BBL) para desenvolver formulações cosméticas. As formulações com 10% em peso de extratos oleosos de Babaçu foram caracterizadas quanto à sua estabilidade durante 30 dias (separação de fases após centrifugação, pH, densidade, viscosidade e distribuição de tamanho das gotículas) e avaliação da eficácia in vivo por biometria cutânea. Os resultados indicaram que as formulações foram fisicamente estáveis e apresentaram comportamento de fluido pseudoplástico, avaliado por reologia. Em relação aos ensaios de eficácia in vivo, a formulação contendo BBL aumentou a hidratação da pele dos voluntários quando comparada com uma formulação contendo apenas um ingrediente hidratante padrão comercial, sem alterar o pH da pele. BBL mostrou ser um ingrediente promissor para cosméticos, comportando-se como um excelente hidratante, provavelmente porque contém as maiores quantidades de ácidos láurico, mirístico e oleico que apresentam grande potencial emoliente.Palavras chave: Formulações cosméticas, biometria cutânea, avaliação in vivo do efeito hidratante, Orbignya phalerata Martius, extrato oleoso vegetal.

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Use of various vegetable oils in designing photoprotective nanostructured formulations for UV protection and antioxidant activity

Cited by 98 publications

References 37 publications

Effect of Ouratea sp. butter in the crystallinity of solid lipids used in nanostructured lipid carriers (NLCs)

Effect of Ouratea sp. butter in the crystallinity of solid lipids used in nanostructured lipid carriers (NLCs)

Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy

Development and in vivo evaluation of the moisturising potential of cosmetic formulations containing Babassu (Orbignya phalerata Martius) oily extract

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