1952
DOI: 10.1038/169794a0
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Use of Unweaned White Mice in Foot-and-Mouth Disease Research

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Cited by 35 publications
(12 citation statements)
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“…ELISA titres were calculated as the reciprocal of the highest dilution that reacted with FMDV particles. The neutralizing activity of the sera was determined in suckling mice (Skinner, 1953); animals were inoculated with 10-fold dilutions of FMDV previously incubated for 1 h at 37 °C with a 1 : 10 dilution of each serum. Neutralizing antibody titres were calculated by the endpoint method (Reed & Muench, 1938).…”
mentioning
confidence: 99%
“…ELISA titres were calculated as the reciprocal of the highest dilution that reacted with FMDV particles. The neutralizing activity of the sera was determined in suckling mice (Skinner, 1953); animals were inoculated with 10-fold dilutions of FMDV previously incubated for 1 h at 37 °C with a 1 : 10 dilution of each serum. Neutralizing antibody titres were calculated by the endpoint method (Reed & Muench, 1938).…”
mentioning
confidence: 99%
“…The antibodies were characterized in the indirect and the indirect sandwich ELISA (Ouldridge et al, 1982) and in neutralization tests (Booth et al, 1978;Skinner, 1953) and by immune electron microscopy. The antibodies in this study were all classified as reactive with the trypsin-sensitive site on the basis of their strong reaction in the indirect sandwich ELISA performed as described above with the purified intact 140S particle and failure to react with purified trypsin-treated 140S particles (Fig.…”
mentioning
confidence: 99%
“…The most significant result was the finding that antiserum to the peptide with the A~2 119C-specific substitution of LoS, although of low titre, neutralized O1 BFS, O1 Kaufbeuren and A~ 2 119C equally. This was corroborated by titrating the serum in the more sensitive mouse index test (Skinner, 1953), in which the infectivity titres ofOt BFS and A~ 2 119C were reduced by 3.5 and 3.9 loglo respectively compared to 5.2 and <0-2 log~0 for the native anti-peptide antiserum.…”
Section: Effect Of Amino Acid 148 On the Specificity Of Peptide Antiseramentioning
confidence: 80%