Use of Ultrasound Urodynamics to Identify Differences in Bladder Shape Between Individuals With and Without Overactive Bladder

S, Glass Clark; As, Nagle; Bernardo, Rachel; Vinod, Naomi; Carucci, Laura R.; Carroll, Ashley; Speich, John E.; Ap, Klausner

doi:10.1097/spv.0000000000000638

Cited by 9 publications

(10 citation statements)

References 25 publications

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“…In this regard, many prior studies have shown that bladder shape may be important in OAB . Glass et al showed differences in bladder shape between individuals with and without OAB, and Atesci et al recently demonstrated that changes in bladder shape may contribute to lower urinary tract symptoms in men, which “may be improved if modifiable factors including increased waist circumference and loosening of the urachus are corrected”. Likewise, Habteyes et al demonstrated that during filling the wall stress of the bladder increases significantly during a load.…”

Section: Discussionmentioning

confidence: 99%

“…[6][7][8][9][10][11] Some of these studies have used a tablet-based sensation meter that participants used to track real-time, unprompted bladder sensation. 6,8 In addition, several previous studies have used three-dimensional (3D) ultrasound to measure bladder volume, 12 shape, 13 and biomechanics. 14 Together, the use of the sensation meter and ultrasound permits non-invasive assessments of bladder sensation and function; however, these techniques require participant training on the use of the sensation meter, and bladder sensation is potentially influenced by pressure from the ultrasound probe.…”

Section: Introductionmentioning

confidence: 99%

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Validation of a real‐time bladder sensation meter during oral hydration in healthy adults: Repeatability and effects of fill rate and ultrasound probe pressure

Sheen

Kolli

Nagle

et al. 2019

LUTS

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Objectives A non‐invasive protocol was previously developed using three‐dimensional ultrasound and a sensation meter to characterize real‐time bladder sensation. This study the protocol by measuring the effects of fill rateand ultrasound probe pressure during oral hydration. Methods Healthy volunteers with no urinary symptoms (based on International Consultation on Incontinence Questionnaire on Overactive Bladder surveys) were recruited into an oral hydration study. Throughout two complete fill–void cycles, participants drank 2 L Gatorade G2 (The Gatorade Company, Inc., Chicago, Illinois) and used a touch‐screen sensation meter to record real‐time bladder sensation (0%‐100%). The study was repeated three times, once per week (Visits A, B, and C). In Visits A and B, ultrasound was used to measure bladder volume every 5 minutes. Ultrasound was not used in Visit C except at 100% capacity. Volume data from Visit B were used to estimate volumes throughout the fills in Visit C. Sensation–capacity curves were generated for each fill for comparative analysis. Results Ten participants completed three visits (60 total fills). Increased fill rate led to decreased sensation throughout filling, andultrasound probe pressure led to increased sensation. Participants reported higher sensation at low volumes during Fill 1 of Visit A before training with the sensation meter. Sensation curves with intermittent ultrasound showed repeatability for Fill 2 in Visits A and B. Fill rate and ultrasound probe pressure affect real‐time bladder sensation during oral hydration. Conclusions This study demonstrated repeatability of real‐time bladder sensation during a two‐fill oral hydration protocol with ultrasound.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Validation of a real‐time bladder sensation meter during oral hydration in healthy adults: Repeatability and effects of fill rate and ultrasound probe pressure

Sheen

Kolli

Nagle

et al. 2019

LUTS

Self Cite

View full text Add to dashboard Cite

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“…Alterations in the ultrasound-measured height-to-width ratios of bladders were associated with OAB, identifying a possible shape-associated OAB subtype. [68] Unfortunately, the use of ultrasound to measure bladder wall thickness has not shown to be an effective method for evaluation of DO. [69][70] In addition to its utility in BOO, doppler ultrasound is currently being evaluated for diagnostic utility of chronic pelvic ischemia leading to DO and potentially detrusor underactivity.…”

Section: Emerging Technologies and Methods To Evaluate The Filling Phasementioning

confidence: 99%

“…[66][67] Abnormal bladder fill shape in OAB. 68 Sturm 63 , Bayat 64 , Nenadic 65 , Nagle 66 , Habteyes 67 , Glass 68…”

Section: Detrusor Biomechanical Propertiesmentioning

confidence: 99%

New Diagnostics for Male Lower Urinary Tract Symptoms

Swavely

Speich

Stothers

et al. 2019

Curr Bladder Dysfunct Rep

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Purpose of review: Lower urinary tract symptoms (LUTS) is a common constellation of symptoms that affect the aging male population with an astonishing prevalence. New technology and new uses of established technology are being used to help further evaluate LUTS in the male population and help guide treatment options. This review focuses on the developments and future directions in diagnostic modalities for evaluation of male LUTS, focusing on evaluation of both the filling and voiding phases of micturition. Recent findings: New techniques in evaluating the voiding phase include penile cuff test, external pressure sensing condom catheter, ultrasound measurement of detrusor wall thickness, ultrasound measurement of intravesical prostatic protrusion, doppler ultrasound and NIRS technology. Evaluation of the filling phase is still undergoing much development and requires additional validation studies. The techniques undergoing evaluation include sensation meters during UDS, assessing bladder micromotion and wall rhythm, assessing detrusor wall biomechanics, ultrasound measurement of detrusor wall thickness, pelvic doppler ultrasound, as well as functional brain imaging including fNIRS and fMRI. Summary: The development of novel, non-invasive, diagnostic tools have the potential for better evaluation of LUTS with earlier and enhanced treatments. This will likely improve the quality of life for men with LUTS.

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“… 7 Recent studies indicate that US-based bladder shape analysis may be useful for the assessment of overactive bladder (OAB). 8–10 Glass Clark et al used 3-D US imaging to quantify bladder height-to-width ratios in a group of women with OAB and a control group of age and body-mass-index-matched women without OAB. 8 They found that bladder shapes for 5/11 women with OAB were outside the 95% confidence intervals for the control group, potentially identifying an OAB subgroup with irregular bladder shapes.…”

Section: Introductionmentioning

confidence: 99%

Repeatability of Ultrasound-Defined Bladder Shape Metrics in Healthy Volunteers

Maddra¹,

Li²,

Nagle³

et al. 2022

RRU

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Purpose Recent studies demonstrate the potential value of using non-invasive abdominal ultrasound to quantify bladder shape and its association with disorders of bladder filling and voiding. The aim of the present study was to assess the repeatability of ultrasound-defined bladder shape metrics within the same individual from multiple bladder fills and study visits. Patients and Methods Healthy volunteers completed an oral hydration protocol with two weekly visits, each with two consecutive bladder fill-void cycles, providing four total fills per participant. Throughout filling, 3-dimensional (3-D) ultrasound images were recorded at 5-minute intervals. Perimeters were manually traced in six cross-sectional planes 30° apart using GE 4D-View software. Diameters, perimeters and cross-sectional areas for the transverse, sagittal and coronal planes were interpolated at three standard bladder volumes of 200, 300, and 400mL. To quantify repeatability, intraclass correlation coefficients (ICCs) and normalized mean absolute differences were calculated for each metric at each standard volume. Moderate and good repeatability were defined as ICC ≥0.5 and ICC ≥0.75, respectively. Results Data from 16 healthy volunteers (9 females, 7 males) were analyzed. ICCs for the transverse vertical and horizontal diameters showed good repeatability, and five of nine perimeter ICCs showed moderate or good repeatability. The mean absolute difference/mean ratio was ≤4% for all perimeter measurements, indicating repeatability was consistent for multiple fills and visits. Conclusion Initial evidence indicates that bladder shape metrics are relatively repeatable and therefore feasible to pursue as a non-invasive tool for potential evaluation of bladder function.

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Use of Ultrasound Urodynamics to Identify Differences in Bladder Shape Between Individuals With and Without Overactive Bladder

Cited by 9 publications

References 25 publications

Validation of a real‐time bladder sensation meter during oral hydration in healthy adults: Repeatability and effects of fill rate and ultrasound probe pressure

Validation of a real‐time bladder sensation meter during oral hydration in healthy adults: Repeatability and effects of fill rate and ultrasound probe pressure

New Diagnostics for Male Lower Urinary Tract Symptoms

Repeatability of Ultrasound-Defined Bladder Shape Metrics in Healthy Volunteers

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