Use of Trichophytin in Thromboangiitis Obliterans

Holman, John C.

doi:10.1001/archderm.1947.01520040081008

Cited by 12 publications

(11 citation statements)

References 2 publications

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“…Bergstrom (8) identified the 9-and the ]3-hydroxystearic acids from hydrogenation of autoxidized linoleie acid. Hohnau (9) has suggested that the conjugated forms can be expected as sole primary oxidation products from autoxidation of methyl linoleate, which thus allows two isomeric monohydroxy conjugated-diene methyl linoleates as expected products from HI reduction of the autoxidized methyl linoleate: It is believed that these two isomeric conjugated diene methyl hydroxylinoleates may well be the compounds which contribute the observed bands.…”

Section: Resultsmentioning

confidence: 99%

An infrared absorption study of autoxidized methyl linoleate

Dugan

Beadle

Henick

1949

J Americ Oil Chem Soc

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Summary A study has been made of the infrared absorption spectra of autoxidized methyl linoleate in samples ranging from PV 1 to PV 940 m.e./kg. Principal changes occur in the frequency range 3400–3550 cm−1 where bonded−OH groups absorb and at 1650–1775 cm−1 where >c=0 groups absorb. Two maxima were observed in oxidized samples in the −OH absorption range: one sharp and distinct at 3467–70 cm−1 which increased in intensity with increase in PV and a broad band which increased with increasing PV until it resolved into a true maximum at 3430 cm−1. Reduction of typical oxidized samples with KI reagent resulted in disappearance of the 3430 cm−1 band and appearance of a new band above 3500 cm−1. The band at 3430 cm−1 was attributed to −OOH groups associated by hydrogen bridging. The band at 3467 cm−1 and the band appearing above 3500 cm−1 were attributed to −OH groups, the band at the higher frequency resulting directly from reduction of a hydroperoxide. Absorption due to ketone and aldehyde carbonyl groups appeared only as an indefinite shoulder on the band due to the ester carbonyl. These were resolved by using the intensity of the sample with PV 1 as Io and that for the oxidized samples as I. A plot of Log Io/I then revealed three maxima. These indicate the presence of two and possibly three carbonyl containing substances other than the ester carbonyl in autoxidized methyl linoleate. Absorption in the two critical frequency ranges of fractions of autoxidized methyl linoleate eluted from an adsorption column correlate with interpretations made from ultraviolet absorption studies of the same substances.

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Section: Resultsmentioning

confidence: 99%

An infrared absorption study of autoxidized methyl linoleate

Dugan

Beadle

Henick

1949

J Americ Oil Chem Soc

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“…Lipoxidases seem to be restricted to the plant kingdom but are widespread there (224). At least one has been prepared in crystalline state (225,226,227). The effect of various factors on lipoxidase activity and the mechanism of action have been studied (228 to 231).…”

Section: F At and Protein Oxidationmentioning

confidence: 99%

Respiration of Higher Plants

Goddard¹,

Meeuse²

1950

Annu. Rev. Plant. Physiol.

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“…Bergstrtim (58,59) and Holman (360,361) have found that, as a result of rapid enzymic oxidation of linoleate at low temperature, one pair of conjugated double bonds is formed for each molecule of oxygen absorbed. Furthermore, in the hydrogenated product comparable amounts of 9-and 13-hydroxystearate have been identified, but the 11-isomer appears to be absent (59).…”

Section: H R Maronmentioning

confidence: 99%

Mechanisms of Oxygen Metabolism

Mason

1957

Advances in Enzymology - And Related Areas of Molecular Biology

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Use of Trichophytin in Thromboangiitis Obliterans

Cited by 12 publications

References 2 publications

An infrared absorption study of autoxidized methyl linoleate

An infrared absorption study of autoxidized methyl linoleate

Respiration of Higher Plants

Mechanisms of Oxygen Metabolism

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