Use of Tranquilizers for Mentally Deficient Patients

Adamson, William C.; B, Nellis; Runge, Gretchen; Cleland, Charles C.; Killian, Edward

doi:10.1001/archpedi.1958.02060060161005

Cited by 6 publications

(3 citation statements)

References 1 publication

(1 reference statement)

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“…The placebo effect itself commands a sizeable literature, some investigators attributing as much as 70% improvement to this effect (Eisenberg, 1964;Adamson et al, 1958;Werry et al, 1966).…”

Section: Discussionmentioning

confidence: 99%

Drug Effects on Learning in Children A Selective Review of the Past Thirty Years

Fréeman

1966

J Spec Educ

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“…The placebo effect itself commands a sizeable literature, some investigators attributing as much as 70% improvement to this effect (Eisenberg, 1964;Adamson et al, 1958;Werry et al, 1966).…”

Section: Discussionmentioning

confidence: 99%

Drug Effects on Learning in Children A Selective Review of the Past Thirty Years

Fréeman

1966

J Spec Educ

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“…A subsequent investigation reported the drug as ''helpful'' for 5 of 6 individuals with severe ID and SIB, but the study was unblinded and involved treatment with multiple drugs (Gualtieri and Schroeder 1989). Chlorpromazine, a low potency D 2 blocker with moderate 5-HT effects, has shown no consistent effects on SIB, and studies that have shown ''improvements'' did not utilize objective measures (Adamson et al 1958;Aman 1993;Marholin et al 1979;Miyamoto et al 2002;Zhang and Bymaster 1999). Thioridazine, another low potency D 1 and D 2 antagonist, was not found to be efficacious for SIB in multiple studies (Aman and White 1988;Davis et al 1969;Singh and Aman 1981;Svendsen et al 1988).…”

Section: Typical Antipsychoticsmentioning

confidence: 99%

Multidisciplinary Assessment and Treatment of Self-Injurious Behavior in Autism Spectrum Disorder and Intellectual Disability: Integration of Psychological and Biological Theory and Approach

Minshawi

Hurwitz

Morriss

et al. 2014

J Autism Dev Disord

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The objective of this review is to consider the psychological (largely behavioral) and biological [neurochemical, medical (including genetic), and pharmacological] theories and approaches that contribute to current thinking about the etiology and treatment of self-injurious behavior (SIB) in individuals with autism spectrum disorder and/or intellectual disability. Algorithms for the assessment and treatment of SIB in this context, respectively, from a multidisciplinary, integrative perspective are proposed and challenges and opportunities that exist in clinical and research settings are discussed.

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“…A wide variety of pharmacologie interventions have been found ineffective, or partially or inconsistently effective, in treating SIB: for example, neuroleptics (Adamson et al 1958, Durand 1982, Le Vann 1969, Tischler et al 1972), tricyclic antidepressants (Chandler et al 1988, Hardy et al 1984, Nyhan et al 1980), lithium (Cooper and Fowlie 1973, Dostal and Zvolsky 1970, Micev and Lynch 1974, psychostimulants Department of Child Psychiatry and Child Development, Boston University School of Medicine, Boston and The Perkins School for the Blind in Watertown, MA. (Davis et al 1969), carbamazepine (Singh and Winton 1984), benzodiazepines (Ciaranello et al 1976, Misuno andYugari 1975), buspirone (Ratey et al 1989), ß-adrenergic receptor blockers (Ruedrich et al 1990), and opiate antagonists naloxone (Davidson et al 1983;Sandman et al 1983Sandman et al , 1987Sandyk 1985) and naltrexone (Barrett et al 1989, Bernsteinetal.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Effect of Fluoxetine on Naltrexone-Resistant Self-Injurious Behavior in an Adolescent with Mental Retardation

Bass¹,

Beltis²

1991

Journal of Child and Adolescent Psychopharmacology

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A significant and sustained reduction in self-injurious behavior (SIB) was observed in a 17-year-old male with severe to profound mental retardation who was treated in an open clinical trial with fluoxetine. The 45-55% reduction in SIB was accompanied by improvement in affective stability, motor capacities, and social activity. No adverse effects or diminishing therapeutic effects were observed during 2 years of treatment at 40 mg daily. Twelve weeks before the start of the fluoxetine trial, this adolescent had been found to be unresponsive to the opiate receptor blocker naltrexone in a double-blind placebo-controlled trial following identical methodology. This case raises the possibility that different patients with SIB may respond preferentially to pharmacological treatments that modify either serotonin or endorphin mechanisms. The findings also suggest that some cases of SIB may represent a type of obsessive-compulsive disorder or body grooming disorder. Additional clinical studies are needed before fluoxetine can be considered for routine use in treating SIB.

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Use of Tranquilizers for Mentally Deficient Patients

Cited by 6 publications

References 1 publication

Drug Effects on Learning in Children A Selective Review of the Past Thirty Years

Drug Effects on Learning in Children A Selective Review of the Past Thirty Years

Multidisciplinary Assessment and Treatment of Self-Injurious Behavior in Autism Spectrum Disorder and Intellectual Disability: Integration of Psychological and Biological Theory and Approach

Therapeutic Effect of Fluoxetine on Naltrexone-Resistant Self-Injurious Behavior in an Adolescent with Mental Retardation

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