Use of tranexamic acid in medial open wedge high tibial osteotomy

Petersen, Wolf; Bentzin, Mats; Bierke, Sebastian; Park, Hi Un; Häner, Martin

doi:10.1007/s00402-021-04219-x

Cited by 15 publications

(29 citation statements)

References 35 publications

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“…[23]. Peters et al, also showed signi cantly lower VAS pain score and higher ROM at the time of discharge in TXA group in open wedge high tibial osteotomy surgery [27]. The plasmin pro les of different body parts in pigs vary, and this may be true for humans as well.…”

Section: Discussionmentioning

confidence: 95%

Does Tranexamic acid diminish hemorrhage and pain in open elbow arthrolysis? a systematic review and meta-analysis

Nejat,

Khayami,

Daliri

et al. 2023

Preprint

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Background/Objective Effective hemostasis has the potential to reduce inflammation and pain, leading to potential benefits in the early rehabilitation of patients who undergo elbow arthrolysis. In the present study, we aim to assesse the effects of tranexamic acid (TXA) on elbow arthrolysis postoperative blood loss, patients' pain perception according to the visual analog scale (VAS), elbow range of motion (ROM), and complications. Methods We systematically searched PubMed, Web of Science, SCOPUS, and Cochrane Library for studies comparing blood loss between intravenous (IV) TXA and placebo/no treatment. One randomized clinical trial, and three non-randomized clinical trial studies met eligibility criteria. Results The meta-analysis determined that tranexamic acid application reduced drain output 34mm on average (WMD: -34.00 (95% CI: -49.45, -18.55). There was a discrepancy among included articles in terms of intra-operative blood loss; although the study with the largest sample size (291 and 296 patients in the case and control groups, respectively) reported reduced intra-operative blood loss in patients who received TXA. Results for pain intensity, ROM, and complications such as hematoma and ulnar nerve palsy were inconsistent. Conclusion TXA may be beneficial to reduce elbow arthrolysis bleeding volume. However, it dose not seem to affect final elbow ROM and patients’ pain score. Further high-quality clinical trials are needed to draw a robust conclusion on this topic. Level of evidence:level I (systematic review and meta analysis)

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Section: Discussionmentioning

confidence: 95%

Does Tranexamic acid diminish hemorrhage and pain in open elbow arthrolysis? a systematic review and meta-analysis

Nejat,

Khayami,

Daliri

et al. 2023

Preprint

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show abstract

“…Two studies examined pain as measured on a visual analogue scale (VAS) for the assessment of pain [17, 19]. In both studies mean VAS for pain at the first postoperative day was significantly lower in the TXA group in comparison to the non TXA group.…”

Section: Resultsmentioning

confidence: 99%

“…The clinical benefit of the use of TXA in osteotomies around the knee has been questioned, as previous studies could not show a difference in the transfusion rate or wound complications between the two treatment groups [10]. This may be due to the fact that the number of cases in previous studies was too low to detect a significant difference in the transfusion rates [2, 7, 16, 17, 19, 23, 24] The present meta‐analysis is the first study to show an effect of tranexamic acid on complication rates such as transfusions and wound complications in osteotomies around the knee. Due to pooling of data of the previous studies the number of cases was large enough to calculate statistical significance.…”

Section: Discussionmentioning

confidence: 99%

“…examined postoperative pain as additional outcome measure [17, 19]. In both studies, pain measured with a visual analog scale (VAS) at the first postoperative day was significantly lower in the TXA group [17, 19]. In one study postoperative range of motion was higher in the TXA group whereas calf diameter and intraarticular effusion were less in the TXA group [19].…”

Section: Discussionmentioning

confidence: 99%

“…In one study postoperative range of motion was higher in the TXA group whereas calf diameter and intraarticular effusion were less in the TXA group [19]. However, there was no difference in PROMs at 1 year after surgery [19].…”

Section: Discussionmentioning

confidence: 99%

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The use of tranexamic acid reduces blood loss in osteotomy at knee level: a systematic review

Bierke

Häner

Bentzin

et al. 2022

Knee Surg Sports Traumatol Arthrosc

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Purpose Aim of this systematic review was to evaluate the literature regarding the efect of tranexamic acid (TXA) on the outcome after knee osteotomy. Methods A systematic literature search was carried out in various databases on studies on the use of tranexamic acid in osteotomies around the knee. Primary outcome criterion was the hemoglobin (drop). Secondary outcome criteria were total blood loss, drainage volume, adverse efects such as thromboembolic events, blood transfusions, wound complications and clinical scores. A meta-analysis was performed for quantitative measures. The present study was registered prospectively (www. crd. york. ac. uk/ PROSP ERO; no.: CRD42021229624). Results Seven studies with 584 patients (TXA group: 282 patients, non TXA group: 302 patients) Hemoglobin decrease (1.54 g/dl vs. 2.28 g/dl), blood loss (394.49 ml vs. 595.54 ml) and drainage volume (266.5 ml vs. 359.05 ml) were signiicantly less in the TXA group compared to the non TXA group. No thromboembolic event was noted in any study. In the non TXA group four blood transfusions were given. Eleven wound complications occurred in the non TXA group in comparison to two wound complications in the TXA group. ConclusionsThe results of the present study show that the application of TXA reduces hemoglobin drop, blood loss and drainage volume. These efects could be responsible for the lesser rate of side efects after administration of TXA during knee osteotomy. KeywordsHigh tibial osteotomy • Medial open wedge osteotomy • Distal femoral osteotomy • HTO • DFO • Osteotomy and tranexamic acid * Wolf Petersen

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Subtuberositäre anterior schließende Osteotomie zur Korrektur der erhöhten posterioren Reklination des Tibiaplateaus

Petersen,

Al Mustafa,

Häner

et al. 2024

Oper Orthop Traumatol

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Use of tranexamic acid in medial open wedge high tibial osteotomy

Cited by 15 publications

References 35 publications

Does Tranexamic acid diminish hemorrhage and pain in open elbow arthrolysis? a systematic review and meta-analysis

Does Tranexamic acid diminish hemorrhage and pain in open elbow arthrolysis? a systematic review and meta-analysis

The use of tranexamic acid reduces blood loss in osteotomy at knee level: a systematic review

Subtuberositäre anterior schließende Osteotomie zur Korrektur der erhöhten posterioren Reklination des Tibiaplateaus

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