Use of trabecular bone score for risk stratification of patients with monoclonal gammopathy of undetermined significance

Sfeir, Jad; Guzman, Tito D. Pena; Bedatsova, Lucia; Broski, Stephen M.; Drake, Matthew T.

doi:10.1016/j.bone.2020.115394

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…The association between MGUS and bone fragility has been well documented in the literature, with an increased risk of VF and/or osteoporosis in MGUS patients compared to controls ( Golombick and Diamond, 2008 ; Gregersen et al, 2006 ; Bida et al, 2009 ; Kristinsson et al, 2010 ; Sfeir et al, 2020 ; Ng et al, 2011 ). Similarly, the association between MM and low bone mineral density has been less studied ( Mariette et al, 1992 ).…”

Section: Discussionmentioning

confidence: 86%

High rate of progression to symptomatic multiple myeloma in patients with smoldering myeloma and isolated osteoporotic vertebral fracture

Chevalier,

Hamroun,

Bitoun

et al. 2024

Bone Reports

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Section: Discussionmentioning

confidence: 86%

High rate of progression to symptomatic multiple myeloma in patients with smoldering myeloma and isolated osteoporotic vertebral fracture

Chevalier,

Hamroun,

Bitoun

et al. 2024

Bone Reports

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“…Other risk factors for FF noted in our cohort are also known risk factors for osteoporosis (diabetes mellitus and smoking) [ 15 ]. In addition, the finding that osteoporotic T -scores were not associated with fracture risk has been shown in other hematologic populations [ 16 ]. This highlights the limitations of DXA in predicting fractures in these populations.…”

Section: Discussionmentioning

confidence: 95%

Risk Factors for Fragility Fractures in Chronic Lymphocytic Leukemia

Petty,

Stephens,

Sharma

2024

Cureus

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Abnormal bone health and fragility fractures (FF) are more common in patients with chronic lymphocytic leukemia (CLL). We hypothesize that there may be risk factors in CLL patients with osteoporosis that increase the risk of FFs. We conducted a cohort study encompassing all patients diagnosed with CLL from January 1, 2000, to July 31, 2020, utilizing International Classification of Diseases (ICD) codes related to abnormal bone health (osteopenia, osteoporosis, and/or presence of FF) within a single tertiary care institution. Of the 89 patients included, 55 (62%) were female with a mean age of 68 ± 11 years at cohort entry. Fifty-nine (66%) had at least one FF present (pFF) and 30 (34%) did not have an FF (nFF). There were no differences in IGHV (Immunoglobulin heavy chain variable region gene) mutation status, chromosomal abnormalities, or the presence of a complex karyotype. The spine accounted for 81% of identified FF. T -score <-2.5 was more common in those without FF (pFF 38% vs. nFF 71%, P = 0.02). DXA evaluation was not conducted for 36 (40%) individuals within the cohort. Risk factors for fragility fractures included male sex (relative risk [RR] 8.1, 95% confidence interval [CI] 2.1-31.7), diabetes mellitus (RR 1.4, 95% CI 1.04-1.8), smoking (RR 1.3, 95% CI 1.02-1.8), Rai stage >0 (RR 1.4, 95% CI 1.04-1.9), and T -score >-2.5 (RR 1.8, 95% CI 1.1-3.1). There is a high frequency of vertebral FFs in people with CLL despite T -scores not being in the osteoporotic range. Increased awareness to screen and treat vertebral FFs in people with CLL is needed.

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“…A BMD Z‐score ≤ −2.0 from the patient's DXA lumbar spine (L1–L4), the femoral neck, or the total hip region was defined as “below the expected range for age,” and a BMD Z‐score above −2.0 was defined as “within the expected range for age” (“2019 ISCD Official Positions‐Adult,” 2019). TBS values <1.31 represented degraded/partially degraded bone quality and ≥1.31, represented normal bone quality (McCloskey et al, 2016; Sfeir, Pena Guzman, Bedatsova, Broski, & Drake, 2020).…”

Section: Methodsmentioning

confidence: 99%

Bone quality assessed by trabecular bone score in severe anorexia nervosa: A brief report

Watters

Fielding

Mehler

2021

Intl J Eating Disorders

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Objective Low bone mineral density (BMD) in anorexia nervosa (AN) leads to increased risk of fractures. Debate exists whether to medicinally treat young patients with AN based on abnormal dual‐energy x‐ray absorptiometry (DXA) scores or to weight restore and reassess when older. Trabecular bone score (TBS), a technology measuring bone quality, is used in conjunction with DXA. This report explores the potential additional value of TBS, in adults with severe AN, to augment the DXA diagnostic information. Method Seventy‐one DXA scans were reanalyzed to obtain TBS results from patients (mean age: 36.3 years). Differences in laboratory, anthropometric values and concomitant DXA measurements in relation to TBS results are reported. Results For the cohort, mean body mass index (BMI) was 13.6 kg/m2 (SD: 2.1). The vast majority of patients had normal TBS with a mean of 1.395 (SD: 0.08) but, most patients (69%) had abnormal average DXA BMD Z‐scores of −2.2 (SD: 1.2). The patients who also demonstrated degraded bone quality on TBS had significantly lower percent ideal body weight and elevated alkaline phosphatase compared to patients with normal TBS (p's < .05). Discussion Low BMD treatment decisions in AN may be optimized by considering both DXA and TBS results.

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Use of trabecular bone score for risk stratification of patients with monoclonal gammopathy of undetermined significance

Cited by 5 publications

References 30 publications

High rate of progression to symptomatic multiple myeloma in patients with smoldering myeloma and isolated osteoporotic vertebral fracture

High rate of progression to symptomatic multiple myeloma in patients with smoldering myeloma and isolated osteoporotic vertebral fracture

Risk Factors for Fragility Fractures in Chronic Lymphocytic Leukemia

Bone quality assessed by trabecular bone score in severe anorexia nervosa: A brief report

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