Use of Topical Tranexamic Acid or Aminocaproic Acid to Prevent Bleeding After Major Surgical Procedures

Ipema, Heather J.; Tanzi, Maria G.

doi:10.1345/aph.1q383

Cited by 65 publications

(50 citation statements)

References 68 publications

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“…9 It is widely used in different surgical procedures such as cardiac surgery, upper gastrointestinal bleeding and post-partum haemorrhage. [10][11][12][13] Multiple reports have shown the effectiveness of TXA to control bleeding in knee arthroplasty. [14][15][16][17] However, its route of administration is still a matter of debate.…”

Section: Introductionmentioning

confidence: 99%

Topical versus intravenous tranexamic acid in total knee arthroplasty

Meena

Benazzo

Dwivedi

et al. 2017

J Orthop Surg (Hong Kong)

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Purpose: The aim of this meta-analysis is to examine the efficacy and safety of intra-articular tranexamic acid (TXA) when compared to intravenous (IV) route. Methods: The literature search was conducted using PubMed, Cochrane Library, MEDLINE, EMBASE and China National Knowledge Infrastructure (CNKI). All randomized controlled trials evaluating the effectiveness of topical route and IV route of TXA administration were included. Results: Eight randomized clinical trials comprising of 857 patients were included in this analysis. We found no statistically significant difference in terms of total blood loss, drain output, transfusion requirement, thromboembolic complication, tourniquet time and surgical duration. Conclusion: Topical TXA has a similar efficacy to IV-TXA in reducing total blood loss, drain output, transfusion rate and haemoglobin drop without any increase in thromboembolic complications.

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Section: Introductionmentioning

confidence: 99%

Topical versus intravenous tranexamic acid in total knee arthroplasty

Meena

Benazzo

Dwivedi

et al. 2017

J Orthop Surg (Hong Kong)

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“…The use of tranexamic acid in orthopedic surgery recently has been gaining favor due to its efficacy and ease of use, both in IV and topical usage. Cost, bioavailability, efficacy, and low complications have contributed to the increase in the administration of TXA in TKA [13]. However, some case reports have shown that IV tranexamic acid is associated with a higher rate of pulmonary embolisms [14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

One step closer to sparing total blood loss and transfusion rate in total knee arthroplasty: a meta-analysis of different methods of tranexamic acid administration

Shemshaki

Nourian²,

Nourian

et al. 2015

Arch Orthop Trauma Surg

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“…Topical treatment is cost-effective, and adverse effects or drug interactions have not been reported. 8 There are several published clinical trials for the use of TXA in the obstetric setting as well, but no consensus on its use or guidelines for management. 7 In the view of limited, good-quality evidence is available to inform on the best practices for prevention of bleeding at caesarean section due to placenta previa.…”

mentioning

confidence: 99%

Adjunctive IV tranexamic acid versus topical tranexamic acid application of the placental bed for prevention of postpartum hemorrhage in women with placenta previa: a randomized controlled trial

Shady

Sallam

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Placenta previa one of the famous etiology of excessive blood loss during and after cesarean section. The objective of this study was to determine the effect of prophylactic adjunctive IV versus topical tranexamic acid (TA) on calculated and measured blood loss during and after caesarean section due to placenta previa compared with standard IV oxytocin alone.Methods: In this double-blind randomized controlled trial, 120 women were undergoing caesarean delivery for placenta previa (PP) were randomly allocated to receive 10 IU oxytocin IV after placental delivery, or receive 1 gm tranexamic acid IV just before skin incision plus 10 IU oxytocin IV after placental delivery or received 10 IU oxytocin IV after placental delivery plus 2 gm topical tranexamic acid applied on placental bed. The main outcome was to measure blood loss during and 4-hour post caesarean delivery.Results: 120 women were enrolled (n = 40 in each group). Both groups of women received IV tranexamic acid (Group II) and topical tranexamic acid (Group III) showed great reduction in intraoperative and 4 hours post-operative blood loss compared with (Group I) which received 10 IU oxytocin only (P = 0.0001, 0.0001, 0.0001, 0.0001), so the overall estimated blood loss in group II and III showed highly reduction compared with group I (P = 0.0001, 0.0001).Conclusions: Prophylactic adjunctive TA topical application on the placental bed or iv administration reduces blood loss during and after caesarean delivery in women with a placenta previa. novel application of topical tranexamic acid on the placental bed is effective in reduce intraoperative and postoperative bleeding in comparison with IV route with elimination of theoretical risk of thrombi embolism complication with IV rout.

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Use of Topical Tranexamic Acid or Aminocaproic Acid to Prevent Bleeding After Major Surgical Procedures

Abstract: Topical application of tranexamic acid and aminocaproic acid to decrease postsurgical bleeding after major surgical procedures is a promising strategy. Further data are needed regarding the safety of this hemostatic approach.

Cited by 65 publications

References 68 publications

Topical versus intravenous tranexamic acid in total knee arthroplasty

Topical versus intravenous tranexamic acid in total knee arthroplasty

One step closer to sparing total blood loss and transfusion rate in total knee arthroplasty: a meta-analysis of different methods of tranexamic acid administration

Adjunctive IV tranexamic acid versus topical tranexamic acid application of the placental bed for prevention of postpartum hemorrhage in women with placenta previa: a randomized controlled trial

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