Use of Topical 0.01% Atropine for Controlling Near Work-Induced Transient Myopia: A Randomized, Double-Masked, Placebo-Controlled Study

Guo, Lei; Fan, Liying; Tao, Jun; Hua, Rui; Yang, Qiang; Gu, Hong; Yu, Shiyuan; Li, Linwei; Zhao, Xin

doi:10.1089/jop.2019.0062

Cited by 12 publications

(12 citation statements)

References 22 publications

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“…22 In another study, no serious complications were noted compared with the placebo group after using 0.01% atropine for 14 days in a study of the Chinese population. 23 In accordance with previous studies, no allergy was observed, and our results showed that after 1 month of atropine administration, nine subjects (12.5%) complained of discomfort, mainly soreness and mild tingling, immediately after administration, but this subsided after a few seconds, and 1 subject (1.39%) was dazzled, although these symptoms were mild. However, these symptoms no longer occurred when followed up at 3 and 6 months.…”

Section: Discussionsupporting

confidence: 92%

<p>The Effect of 0.01% Atropine Eye Drops on the Ocular Surface in Children for the Control of Myopia—The Primary Results from a Six-Month Prospective Study</p>

Cheng¹,

Yang²,

Kong³

et al. 2020

TCRM

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To evaluate the effect of 0.01% atropine eye drops on the ocular surface in children for the control of myopia. Methods: A total of 72 participants were recruited for this prospective study. Prior to and after 1, 3, and 6 months of 0.01% atropine administration, an ocular surface disease index (OSDI) questionnaire was obtained, Keratograph 5M was used for the measurement of the tear meniscus height (TMH), noninvasive keratographic tear film break-up time (NK-BUT, the first keratographic break-up time, [NK-BUT first ] and the average keratographic break-up time, [NK-BUT ave ]), bulbar redness (BR), meiboscore (MS), and anterior segment optical coherence tomography (AS-OCT) was used to calculate the inferior tear meniscus area (TMA). Results: After using the 0.01% atropine eye drops for 1 month, 9 subjects complained of discomfort immediately after administration, but this quickly subsided, and 1 subject was temporarily dazzled. All the ocular surface symptoms were mild and occurred rarely. After 3 months, these complaints no longer occurred. Compared with the baseline values, the OSDI scores (0.08 ± 0.28), values of TMH (0.23 ± 0.04 mm), TMA (0.0420 ± 0.0444 mm 2), NK-BUT first (9.39 ± 5.25 s), NK-BUT ave (10.49 ± 4.94 s), BR (0.63 ± 0.37), and MS (0.89 ± 0.70) did not change significantly after 6 months of 0.01% atropine eye drop administration (P > 0.05). Conclusion: In this 6-month prospective study, no side effects were observed on the ocular surface after using 0.01% atropine in children.

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Section: Discussionsupporting

confidence: 92%

<p>The Effect of 0.01% Atropine Eye Drops on the Ocular Surface in Children for the Control of Myopia—The Primary Results from a Six-Month Prospective Study</p>

Cheng¹,

Yang²,

Kong³

et al. 2020

TCRM

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“… 20 , 21 , 22 Recently, a randomized study assessed the efficacy of a low-concentration of atropine (0.01%) on the initial NITM magnitude among Chinese myopic children aged 6–15 years. 23 They reported that the initial NITM magnitude was significantly reduced for approximately 0.45D after 7 and 14 days of instilling atropine. 23 This study suggests, to some extent, that atropine may slow down the myopia progression through reducing initial NITM magnitude.…”

Section: Discussionmentioning

confidence: 99%

“… 23 They reported that the initial NITM magnitude was significantly reduced for approximately 0.45D after 7 and 14 days of instilling atropine. 23 This study suggests, to some extent, that atropine may slow down the myopia progression through reducing initial NITM magnitude. However, there was no direct data on the association between NITM and refractive change, so this remains speculative.…”

Section: Discussionmentioning

confidence: 99%

The association between nearwork-induced transient myopia and progression of refractive error: A 3-year cohort report from Beijing Myopia Progression Study

Zhong

Vasudevan

Liang

et al. 2021

Journal of Optometry

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Purpose To investigate the natural change of nearwork-induced transient myopia (NITM), and its association with the progression of refractive error. Methods Students of the Beijing Myopia Progression Study were examined at baseline and follow-up examinations, which included cycloplegic autorefraction. Initial NITM and its decay were assessed objectively immediately after binocularly-viewing and performing a sustained 5-minute near task (20 cm). Results There were 223 students with both NITM and cycloplegic refractive data enrolled. There were 142 myopic (63.7%), 32 emmetropic (14.4%), and 49 hyperopic (22.0%) students according to their baseline cycloplegic refraction. The annual refractive change was −0.45 (−0.73, −0.21) D. From the baseline to the one-year and two-year follow-up periods, the initial NITM (median) increased significantly in the myopic students (0.16, 0.21, and 0.20D, p = 0.01, respectively). The overall proportion of NITM decay types shifted significantly from none being induced at baseline (non-induced: 17.0%, complete decay 57.4%, incomplete decay 25.6%) to incomplete decay at the 2-year follow-up (non-induced: 6.7%, complete decay 65.0%, incomplete decay 28.3%, p = 0.01). For the hyperopic students, after adjusting for risk factors, for every 1 diopter increase in the initial NITM at baseline, there was approximately a −1.48 diopter more relative myopic refractive progression (p = 0.01). No significant association was found between refractive change and the NITM parameters for either the myopic or emmetropic students after adjusting for the same confounders. However, this relation was significant in the hyperopes (p = 0.01). Conclusion NITM was only found to be significantly associated with the progression of a myopic refractive shift among the hyperopes.

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“…15,28 Some studies suggested that topical use of 0.01% atropine can efficiently control transient myopia caused by work in adolescents. 29 However, the study of Larkin et al 30 showed that 0.01% atropine eye drops considerably slows the progression of myopia in a group of American children who have been treated for more than 2 years. In a 6-month prospective study of Cheng et al, 31 atropine at a concentration of 0.01% shows no obvious side effects on the ocular surface in children with myopia.…”

Section: Discussionmentioning

confidence: 99%

Low concentration atropine combined with orthokeratology in the treatment of axial elongation in children with myopia: A meta-analysis

Yang¹,

Bai²,

Liu³

2021

European Journal of Ophthalmology

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Objective: To evaluate the effect of low concentration atropine combined with Orthokeratology (OK) lens compared with the OK lens on the changes of axial length in children with moderate and low myopia by meta-analysis. Methods: Databases such as PubMed, Web of Science, Embase, and Cochrane Library were comprehensively searched to collect related studies on atropine combined with the OK lens in the treatment of children with moderate and low myopia. The retrieval time was from the establishment of the database to December 2020. The standardized mean difference (SMD) and its 95% confidence interval (CI) were selected as the effect to analyze the changes of the axial length of the eye axis in children with low and moderate myopia treated with low concentration atropine combined with OK lens. Results: A total of eight articles were included in this study. Compared with OK lens treatment, low concentration atropine combined with the OK lens significantly slowed down the axial elongation of low and moderate myopia, SMD = −0.68(95% CI: −0.86–−0.50, p < 0.05). According to the subgroup analysis of treatment time, when the treatment time was less than or equal to 6 months, SMD = −0.63(95% CI: −0.88–−0.37, p < 0.05), when the treatment time was 1 year, SMD = −0.76(95% CI: −1.08–−0.43, p < 0.05), and when the treatment time was 2 years, SMD = −0.69(95% CI: −1.07–−0.31, p < 0.05). Conclusion: Low concentration atropine combined with the OK lens is more effective than the OK lens in the treatment of children with low to moderate myopia in reducing axial elongation.

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Use of Topical 0.01% Atropine for Controlling Near Work-Induced Transient Myopia: A Randomized, Double-Masked, Placebo-Controlled Study

Cited by 12 publications

References 22 publications

<p>The Effect of 0.01% Atropine Eye Drops on the Ocular Surface in Children for the Control of Myopia—The Primary Results from a Six-Month Prospective Study</p>

<p>The Effect of 0.01% Atropine Eye Drops on the Ocular Surface in Children for the Control of Myopia—The Primary Results from a Six-Month Prospective Study</p>

The association between nearwork-induced transient myopia and progression of refractive error: A 3-year cohort report from Beijing Myopia Progression Study

Low concentration atropine combined with orthokeratology in the treatment of axial elongation in children with myopia: A meta-analysis

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