A 3 days old cross bred Murrah buffalo calf with a history of lateral recumbency following birth after dystocia was presented to the department of veterinary surgery and radiology, VCC, RIVER, Puducherry. On examination of the right fore limb, crepitus was felt at the distal end of humerus. A complete oblique fracture of the distal diaphysis of the humerus was confirmed on radiography. Under sedation surgically by tie-in configuration fracture was treated. Tie-in configuration frame was protected with application of POP cast. Inj. Streptopenicillin @ 10 mg/kg B.W. administered I/M for 5 days. Inj. Meloxicam @ 0.4mg/kg B.W I/M for 3 days were administered postoperatively. On 45 th post-operative day clinical union of fracture was confirmed with callus formation on radiograph. Tie-in configuration was removed and on 60 th day weight bearing was noticed. Animal made an uneventful recovery.