Use of thyroid hormones in relation to pregnancy: a Danish nationwide cohort study

Gidén, Karin; Andersen, Jón Trærup; Torp-Pedersen, Arendse; Poulsen, Henrik Enghusen; Torp‐Pedersen, Christian; Jimenez-Solem, Espen

doi:10.1111/aogs.12621

Cited by 6 publications

(6 citation statements)

References 25 publications

(38 reference statements)

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“…Furthermore, the proportion of women who discontinued THRT, as well as the group characteristics of the continuers and discontinuers in the present study, was similar to that reported by Gidén et al . In the crude comparison, discontinuers more often had an unplanned pregnancy than did continuers (24.6% vs. 17.7%).…”

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Risk factors for discontinuation of thyroid hormone replacement therapy in early pregnancy: a study from the Norwegian Mother and Child Cohort Study and the Medical Birth Registry of Norway

Frank

Lupattelli

Nordeng

2018

Acta Obstet Gynecol Scand

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Section: Discussionsupporting

confidence: 89%

“…A recent study in Denmark reported that 1 in 10 women with hypothyroidism discontinued thyroid hormone replacement therapy (THRT) during pregnancy. In a study by Juch et al , 17% of women with hypothyroidism reported low adherence to THRT during pregnancy, often because of their concerns about possible teratogenic effects.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for discontinuation of thyroid hormone replacement therapy in early pregnancy: a study from the Norwegian Mother and Child Cohort Study and the Medical Birth Registry of Norway

Frank

Lupattelli

Nordeng

2018

Acta Obstet Gynecol Scand

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“…There are only a few comparable studies on LT4 use during pregnancy. A Danish study showed an increase in LT4 use among pregnant women between 1997 and 2010 [20]. However, the authors reported that <1% of pregnant women received LT4 medication, and this proportion is significantly lower than the estimated rate of hypothyroidism in pregnant women (about 2.8%) [20].…”

Section: Discussionmentioning

confidence: 98%

The Increased Trend of Medical Treatment for Thyroid Diseases during Pregnancy: A 13-Year National Study

et al. 2021

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Objective: Thyroid dysfunction affects up to 5–7% of all pregnancies. The rates of thyroid hormone use in nonpregnant population have substantially increased in recent years. The aim of this study was to assess possible changes in the use of levothyroxine substitution and antithyroid drugs over time in pregnant women. Methods: The study data consisted of all singleton pregnancies (N = 736,873) between 2004 and 2016 in Finland collected from the Finnish Medical Birth Register. The Prescription Register and Special Refund Entitlement Register provided information on levothyroxine and antithyroid drug purchases. The annual rates of levothyroxine and antithyroid drug prescription redemptions were explored to estimate changes in exposure rates to thyroid medication from 2004 to 2016. Joinpoint regression analyses were performed to explore interannual variability in levothyroxine and antithyroid drug treatment. Results: There was more than a five-fold increase in levothyroxine use during the study period; in 2004, 1.1% of pregnant women had levothyroxine treatment, and by 2016, the prevalence increased to 6.2%. In addition, we observed a slight increase in antithyroid medication during pregnancy, but antithyroid drug use during pregnancy overall was very rare. In 2004, 0.05% of pregnant women used antithyroid drugs, and by 2016, this percentage had increased to 0.14%. Conclusions: Our study shows that the rate of levothyroxine use in pregnancy has markedly increased. This suggests that tracing and screening relevant patients and awareness of thyroid disorders on pregnancy and their significance for the pregnancy outcome have increased and the threshold to treat thyroid disorders has declined.

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“…[9][10][11][14][15][16][17] We found no difference in fine and gross motor function, communication skills, and behavior. This is important because some women discontinue their THRT upon recognition of pregnancy 37,38 and, among those who are medicated, adherence to THRT is not always optimal. 39 Juch et al 39 found that 17% of pregnant women with hypothyroidism exhibit low adherence during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Thyroid hormone replacement therapy in pregnancy and motor function, communication skills, and behavior of preschool children: The Norwegian Mother, Father, and Child Cohort Study

Broek

Lupattelli

Frank

et al. 2020

Pharmacoepidemiology and Drug

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Purpose: Limited research has focused on the association between prenatal thyroid hormone replacement therapy (THRT) and motor function, communication skills, and behavior in preschool children. Here, we estimated the association between THRT during pregnancy and the first trimester and these developmental outcomes.Methods: This study was based on the Norwegian Mother, Father, and Child Cohort Study (MoBa) and other national registries. We included mother-child pairs exposed to THRT during pregnancy (n = 663), after delivery (n = 728), or unexposed (n = 28 040).Exposure to THRT was defined according to filled prescriptions. Child outcomes, presented as T-score differences, were parent-reported using the Ages and Stages Questionnaire, Strengths and Difficulties Questionnaire, and Child Behavior Checklist.Results: Of 29 431 mother-child pairs, 2.3% were prenatally exposed to THRT. We found no difference between prenatally exposed and unexposed children in regards to gross motor function (β: 0.17, 95% CI −1.19, 1.54), fine motor function (β: −0.17, 95%

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Use of thyroid hormones in relation to pregnancy: a Danish nationwide cohort study

Cited by 6 publications

References 25 publications

Risk factors for discontinuation of thyroid hormone replacement therapy in early pregnancy: a study from the Norwegian Mother and Child Cohort Study and the Medical Birth Registry of Norway

Risk factors for discontinuation of thyroid hormone replacement therapy in early pregnancy: a study from the Norwegian Mother and Child Cohort Study and the Medical Birth Registry of Norway

The Increased Trend of Medical Treatment for Thyroid Diseases during Pregnancy: A 13-Year National Study

Thyroid hormone replacement therapy in pregnancy and motor function, communication skills, and behavior of preschool children: The Norwegian Mother, Father, and Child Cohort Study

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