Use of thyroglobulin as a tumour marker

Indrasena, Buddhike Sri Harsha

doi:10.4331/wjbc.v8.i1.81

Cited by 54 publications

(39 citation statements)

References 21 publications

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“…Several studies found an inverse association between iodine intake and serum Tg (8,9). Moreover, there is an association between thyroid volume and serum Tg (10), and the levels of serum Tg significantly change with thyroid abnormalities and dysfunction such as thyroiditis, autoimmune thyroiditis, and thyroid cancer (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Genetic Variants in theST6GAL1Gene Are Associated with Thyroglobulin Plasma Level in Healthy Individuals

Matana

Popović

Boutin

et al. 2019

Thyroid

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Background: Thyroglobulin (Tg) is a 660 kDa iodoglycoprotein that serves as a scaffold for thyroid hormone synthesis. Although a twin study showed that variability of serum Tg levels has a substantial genetic basis, no genome-wide association study (GWAS) of serum/plasma Tg levels has been performed to date. The aim of this study was to identify genetic variants associated with plasma Tg levels among healthy individuals. Methods: A GWAS was conducted on two Croatian cohorts, and a combined analysis was performed. The analyses included 1094 individuals. A total of 7,597,379 variants, imputed using the 1000 Genomes reference panel, were analyzed for association. GWAS was performed under an additive model, controlling for age, sex, and relatedness within each data set. Combined analysis was conducted using the inverse-variance fixed-effects method. Results: Sixteen variants located on chromosome 3, within the ST6GAL1 gene, reached genome-wide significance. The lead SNP was rs4012172 (p ¼ 1:29 • 10 À 10), which explained 3.19% of the variance in Tg levels. ST6GAL1 belongs to the sialyltransferase protein family, which has a fundamental role in the synthesis of specific sialylated structures on various glycoproteins, including Tg. It is known that only immature Tg (poorly sialylated or desialylated) can be transferred to the bloodstream. Conclusions: A highly biologically plausible locus was identified that could have a role in the regulation of plasma Tg levels in healthy individuals.

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Section: Introductionmentioning

confidence: 99%

Genetic Variants in theST6GAL1Gene Are Associated with Thyroglobulin Plasma Level in Healthy Individuals

Matana

Popović

Boutin

et al. 2019

Thyroid

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“…However, it should be noted that the presence of TgAb may interfere with the measurement of Tg during the detection process, resulting in erroneous results. 16 Although thyroglobulin does not distinguish thyroid cancer from normal thyroid tissue, some studies 17 , 18 have shown that preoperative detection of thyroglobulin may help predict the tumor burden and lymph node metastasis of patients. A study in South Korea 19 believes that patients with preoperative thyroid globulin above 13.15ng/mL can be considered to have ipsilateral cervical lymph node metastasis, while above 30.05ng/mL may also have contralateral cervical lymph node metastasis, if higher than 62.9 ng/mL is at risk for distant metastases.…”

Section: Blood Markersmentioning

confidence: 99%

<p>The Blood Biomarkers of Thyroid Cancer</p>

Wang¹,

Chang²,

Jia³

et al. 2020

CMAR

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Introduction: With the gradual increase in the incidence of thyroid cancer, people's attention to thyroid cancer has also gradually increased. Although the prognosis of thyroid cancer is rather mild compared to other cancers, it will still bring a heavy psychological burden on people who have been diagnosed. At present, the diagnosis of thyroid cancer mainly depends on ultrasound and percutaneous fine needle aspiration (pFNA). Due to the unsatisfactory accuracy of the diagnosis methods we use now, there are still some thyroid nodules that cannot be clearly diagnosed before surgery. Methods: In this article, we have searched for relevant research on blood markers of thyroid cancer in the past five years and categoried them into four groups. Discussion: Though we have not found a biomarker which can diagnose thyroid cancer both sensitively and specifically, we do found many substances that are related to it, and have the potential to recognize it and help the diagnosis. And perhaps combined models can do it better.

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“…The midline uptake on RxWBS indicated the presence of large amounts of the remnant thyroid tissue postoperatively [24]. Regardless of the underlying pathology being benign or malignant, the serum Tg level could be increased because of the thyroid tissue burden [25]. In a previous report, Tg was higher in patients with midline uptake than in patients without it [11].…”

Section: Discussionmentioning

confidence: 86%

Optimization of Predictive Performance for the Therapeutic Response Using Iodine Scan-Corrected Serum Thyroglobulin in Patients with Differentiated Thyroid Carcinoma

Yoo

Chowdhury

Jeon

et al. 2020

Cancers

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We investigated whether the performance of serum thyroglobulin (Tg) for response prediction could be improved based on the iodine uptake pattern on the post-therapeutic I-131 whole body scan (RxWBS) and the degree of thyroid tissue damage with radioactive iodine (RAI) therapy. A total of 319 patients with differentiated thyroid carcinoma who underwent total thyroidectomy and RAI therapy were included. Based on the presence/absence of focal uptake at the anterior midline of the neck above the thyroidectomy bed on RxWBS, patients were classified into positive and negative uptake groups. Serum Tg was measured immediately before (D0Tg) and 7 days after RAI therapy (D7Tg). Patients were further categorized into favorable and unfavorable Tg groups based on the prediction of excellent response (ER) using scan-corrected Tg developed through the stepwise combination of D0Tg with ratio Tg (D7Tg/D0Tg). We investigated whether the predictive performance for ER improved with the application of scan-corrected Tg compared to the single Tg cutoff. The combined approach using scan-corrected Tg showed better predictive performance for ER than the single cutoff of D0Tg alone (p < 0.001). Therefore, scan-corrected Tg can be a promising biomarker to predict the therapeutic responses after RAI therapy.

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Use of thyroglobulin as a tumour marker

Cited by 54 publications

References 21 publications

Genetic Variants in theST6GAL1Gene Are Associated with Thyroglobulin Plasma Level in Healthy Individuals

Genetic Variants in theST6GAL1Gene Are Associated with Thyroglobulin Plasma Level in Healthy Individuals

<p>The Blood Biomarkers of Thyroid Cancer</p>

Optimization of Predictive Performance for the Therapeutic Response Using Iodine Scan-Corrected Serum Thyroglobulin in Patients with Differentiated Thyroid Carcinoma

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