Use of the zirconia-based stationary phase for separation of ibuprofen and its impurities

Kučera, Radim; Sochor, J; Klimeš, Jiřı́; Dohnal, Jiří

doi:10.1016/j.jpba.2005.02.002

Cited by 14 publications

(2 citation statements)

References 29 publications

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“…Another study developed a methodology for determining the intrinsic viscosity of poly(ethylene terephthalate) (PET) which cut the amount of hazardous waste produced relative to previous testing methodologies (Silva Spinacé et al, 2005). In the area of pharmaceutical research, a new method for determination of ibuprofen was developed which cuts down on the amount of hazardous waste produced in the analysis (Kucera et al, 2005).…”

Section: Minimizationmentioning

confidence: 99%

Hazardous Waste Assessment, Management, and Minimization

Hernandez¹,

Uddameri²

2006

Water Environment Research

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Section: Minimizationmentioning

confidence: 99%

Hazardous Waste Assessment, Management, and Minimization

Hernandez¹,

Uddameri²

2006

Water Environment Research

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“…Only the S(+) form of ibuprofen is pharmacological active since the biological receptors are stereo selective. The R(−) and S(+) forms have different physicochemical properties, and the melting point, solubility, and lipophilicity differ among the two forms. − …”

Section: Introductionmentioning

confidence: 99%

Self-Controlled Coating Process for Drugs

Römbach

Ulrich

2007

Crystal Growth & Design

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The principles, the benefits, and the preconditions of a self-controlled coating process were introduced in previous papers by the authors [Römbach, E.; Ulrich, J. In Crystallization Meets Pharmacy; Hirasawa I., Ulrich, J., Eds.; Waseda University, Tokyo, 2005; pp 1−6. Römbach, E.; Ulrich, J. In 16th International Symposium on Industrial Crystallization; VDI Verlag GmbH: Düsseldorf, 2005; pp 701−705]. The applicability of this coating process strongly depends on the thermophysical behavior of the materials chosen. For the thermophysical preconditions of the self-controlled coating process, the phase diagram, the separation effect in pastilles, and the thermal stability have to be considered. Here, a proof of concept is given for the self-controlled coating process on the basis of a case study. The thermal phase behavior, the thermal stability, and the separation effect of the binary mixture of ibuprofen and carnauba wax were investigated. The binary mixture of ibuprofen and carnauba wax forms an eutectic mixture with an eutectic point at 51.68 wt % of ibuprofen and with an eutectic temperature at 73.8 °C.

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Determination of ibuprofen in pharmaceutical formulations using time‐resolved terbium‐sensitized luminescence

Al-Kindy

Suliman

2007

Luminescence

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A sensitive and specific luminescence method for the determination of ibuprofen (IB) in pharmaceutical formulations in aqueous solution is described. The method is based on the luminescence sensitization of terbium (Tb(3+)) by formation of ternary complex with IB in the presence of tri-n-octylphosphine oxide (TOPO) and Tween-20 as surfactant. The luminescence signal for Tb-IB-TOPO is monitored at lambda(ex) = 229 nm and lambda(em) = 545 nm. Optimum conditions for the formation of the complex in aqueous system, were 16 mmol/L TRIS buffer, pH 5.7, TOPO 200 micromol/L and 15 micromol/L of Tb(3+), which allows for the determination of 9.7 x 10(-7) - 9.7 x 10(-6) mol/L IB with a detection limit of 1.2 x 10(-7) mol/L. The relative standard deviations of the method were <1.4%, indicating excellent reproducibility. The proposed method was successfully applied for the assays of IB in pharmaceutical formulations with average recoveries of 100.3-102.5%.

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Use of the zirconia-based stationary phase for separation of ibuprofen and its impurities

Cited by 14 publications

References 29 publications

Hazardous Waste Assessment, Management, and Minimization

Hazardous Waste Assessment, Management, and Minimization

Self-Controlled Coating Process for Drugs

Determination of ibuprofen in pharmaceutical formulations using time‐resolved terbium‐sensitized luminescence

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