Use of the TIMP in Assessment of Motor Development of Infants With Down Syndrome

Kloze, Anna; Brzuszkiewicz-Kuźmicka, Grażyna; Czyżewski, Piotr

doi:10.1097/pep.0000000000000216

Cited by 7 publications

(2 citation statements)

References 13 publications

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“…Malak et al 20 carried out a study with DS children in which the researchers confirmed that the upstanding and gait skills were delayed even when physiotherapy was performed. Other studies on the first months of DS children, however, revealed the vital importance of interventional treatments in the multiple areas of motor development 21,22 .…”

Section: Discussion Interpretationmentioning

confidence: 99%

Foot rotation asymmetry in Down syndrome and the relationship with crawling and walking onset: a cross sectional study

Valero

Mustacchi

Bezerra

et al. 2021

jhgd

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Introduction: Down syndrome individuals have different gait patterns, which include specific characteristics such as foot rotation asymmetry. Objective: The aim of this study was to analyze the relationship between this asymmetry and the previous acquisition of hands-and-knees crawling in Down syndrome children, as well as the probable association of this gait to gender, ethnicity, comorbidities, physiotherapy, and occupational therapy interventions. Methods: In this cross-sectional study, 361 children with or without foot rotation asymmetry were selected. An online questionnaire was administered to the parents or guardians of those children. Results: Hands-and-knees crawling decreased the prevalence of foot rotation asymmetry in Down syndrome children. The longer it took for walking onset, the higher the prevalence of this asymmetry. Indeed, for each month of delay there was a 7% increase in prevalence. There was a significant relationship between orthopedic alterations in knees or flat feet and foot rotation asymmetry. There was no significance related to gender, ethnicity, other comorbidities, physiotherapy or occupational therapy interventions. Conclusion: The findings in this study revealed that foot rotation asymmetry may be related to the acquisition of the motor skills described above, especially with regards to hands-and-knees crawling and walking onset.

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Section: Discussion Interpretationmentioning

confidence: 99%

Foot rotation asymmetry in Down syndrome and the relationship with crawling and walking onset: a cross sectional study

Valero

Mustacchi

Bezerra

et al. 2021

jhgd

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“…Impaired neuro-psychomotor development of children with DS is related to low muscle tone and difficulties in postural control and balance [3][4][5] . The child with DS has intrinsic limitations, such as muscle hypotonia and joint hypermobility, which collaborate for the motor impairment, slowness of movement and postural control changes 6 .…”

Section: Introductionmentioning

confidence: 99%

Influência do ambiente domiciliar no desenvolvimento motor de lactentes com síndrome de Down

et al. 2018

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RESUMO Crianças com síndrome de Down apresentam atrasos no desenvolvimento neuropsicomotor relacionados a tônus muscular, controle postural e equilíbrio. O desenvolvimento motor sofre interferência multifatorial, que envolve características biológicas, psicológicas, sociais e ambientais. Assim, o ambiente em que o lactente está incluído pode atuar como facilitador do desenvolvimento neuropsicomotor. O objetivo deste estudo foi avaliar a influência do ambiente domiciliar no desenvolvimento motor de lactentes com síndrome de Down. Participaram do estudo 16 lactentes com a síndrome, divididos em grupo I (3 a 11 meses) e grupo II (12 a 18 meses), avaliados pela Alberta Infant Motor Scale (AIMS) e pelo questionário Affordances in the Home Environment for Motor Development - Infant Scale (AHEMD-IS). A análise de dados foi feita por meio do teste de Kruskal-Wallis, coeficiente de correlação de Spearman e teste de razão de verossimilhança. Os resultados evidenciaram uma correlação positiva significativa entre o escore bruto da AIMS e a variedade de estímulos (p=0,01, r=0,78) e com o escore total do questionário AHEMD-IS (p=0,02, r=0,74) no grupo II. Verificou-se, ainda, correlação entre a renda familiar e as oportunidades com brinquedos de função motora grossa (p=0,05, r=0,49), porém com correlação fraca. Conclui-se que o ambiente domiciliar tem importante papel no desenvolvimento motor de crianças com síndrome de Down entre 12 e 18 meses, por proporcionar oportunidades de vivências e experimentações. Assim, pode-se afirmar que ambientes mais adequados proporcionam melhor desempenho motor.

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Challenges and Opportunities for Translation of Therapies to Improve Cognition in Down Syndrome

Lee

Duran-Martinez

Khantsis

et al. 2020

Trends in Molecular Medicine

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While preclinical studies have reported improvement of behavioral deficits in the Ts65Dn mouse model of Down syndrome (DS), translation to human clinical trials to improve cognition in individuals with DS has had a poor success record. Timing of the intervention, choice of animal models, strategy for drug selection, and lack of translational endpoints between animals and humans contributed to prior failures of human clinical trials. Here, we focus on in vitro cell models from humans with DS to identify the molecular mechanisms underlying the brain phenotype associated with DS. We emphasize the importance of using these cell models to screen for therapeutic molecules, followed by validating them in the most suitable animal models prior to initiating human clinical trials.

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Use of the TIMP in Assessment of Motor Development of Infants With Down Syndrome

Abstract: The TIMP is a sensitive measure of delayed motor development in infants with DS and can be used to confirm the need for therapy.

Cited by 7 publications

References 13 publications

Foot rotation asymmetry in Down syndrome and the relationship with crawling and walking onset: a cross sectional study

Foot rotation asymmetry in Down syndrome and the relationship with crawling and walking onset: a cross sectional study

Influência do ambiente domiciliar no desenvolvimento motor de lactentes com síndrome de Down

Challenges and Opportunities for Translation of Therapies to Improve Cognition in Down Syndrome

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