Use of the Speckle tracking method for determining global parameters of heart contractility in healthy individuals

Abstract

Graphical abstract

Role of defective calcium regulation in cardiorespiratory dysfunction in Huntington’s disease

“…The remodeling of RyR2 in the heart described above accounts for diastolic SR Ca 2+ leak and subsequent VES ( Figure 6, J and K). Next, we evaluated cardiac function using ECG to measure the left ventricular ejection fraction (LVEF) and speckle tracking imaging that allows earlier detection of left ventricular systolic dysfunction, a strong predictor of heart failure and mortality (77). The LVEF in Q175 mice was normal; however, the left ventricular global longitudinal strain was reduced, indicating a predisposition to heart failure (Supplemental Figure 5, A-C).…”

Assessment of Phasic Changes of Vascular Size by Automated Edge Tracking-State of the Art and Clinical Perspectives

“…Alternative methods to assess phasic changes of vascular size have also been applied or developed by other colleagues (35)(36)(37). Specifically, a method widely used in echocardiography is based on tracking the speckle noise (38), i.e., a random mixture of interference patterns and US reflections characterizing each region of the tissue (like as a fingerprint) that is relatively stable on consecutive frames, allowing the region to be traced from one frame to the next. Speckle tracking has been applied to study the IVC deformation in long axis view (36) or to assess aortic or carotid stiffness (39,40).…”

Antiquated ejection fraction: Basic research applications for speckle tracking echocardiography

“…Despite being well utilized in clinics, echocardiography has only recently been utilized to the full extent of its capabilities in basic research labs. STE has quantitative capabilities to truly measure systolic and diastolic function and contractility ( Marwick et al, 2009 ; Morris et al, 2012 ; Oleynikov et al, 2018 ). STE uses B-mode, which is often the same imaging modality as an M-mode, but records a video clip of the entire heart wall rather than movement along one line.…”