Use of the Shock Wave Therapy in Basic Research and Clinical Applications—From Bench to Bedsite

Rola, Piotr; Włodarczak, Adrian; Barycki, Mateusz; Doroszko, Adrian

doi:10.3390/biomedicines10030568

Cited by 18 publications

(17 citation statements)

References 93 publications

(103 reference statements)

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“…Presumably, the data obtained from intravascular imaging, including the IVUS and/or OCT analyses, would provide valuable and precise information regarding the nature of the calcium burden and evidence of calcium modification, along with a comparison of the acute luminal gain achieved by RA compared with S-IVL. The relationship between this data and different mechanisms of plaque modification using both devices [ 47 , 48 , 49 ] could result in the evaluation of new criteria for optimal subjects who qualify for the primary Left Main Rotablation or/and S-IVL; therefore, we strongly believe that future studies which foreground this issue are of urgent clinical need.…”

Section: Discussionmentioning

confidence: 99%

Intravascular Lithotripsy as a Novel Treatment Method for Calcified Unprotected Left Main Diseases—Comparison to Rotational Atherectomy—Short-Term Outcomes

Rola

Kulczycki²,

Włodarczak

et al. 2022

IJERPH

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Background: The unprotected calcified Left Main disease represents a high-risk subset for percutaneous coronary intervention (PCI), and it is associated with a higher number of periprocedural complications and an increased rate of in-stent thrombosis and restenosis. Adequate lesion preparation plays a crucial role in achieving a favorable PCI outcome. Rotational Atherectomy (RA) is a well-established plaque-modifying method; nevertheless, the data regarding the effectiveness of RA in LM diseases is scarce. Recently, the novel ShockWave-Intravascular-Lithotripsy(S-IVL) device has been introduced to the PCI armamentarium in order to modify the calcified plaque. Methods: We performed a retrospective evaluation of 44 consecutive subjects who underwent the LM-PCI, and who were supported by either the RA or S-IVL. Results: The Rota group consisted of 29 patients with a mean syntax score of 28.0 ± 7.5. The S-IVL group was composed of 15 subjects with a syntax score of 23.3 ± 13.0 There were no statistical differences regarding MACE between the RA and Shockwave arms of the in-hospital group (10.3% vs. 6.7%), or in the six month (17.2% vs. 13.3%) follow-up group. Conclusions: RA and S-IVL could be safe and effective therapeutic strategies for calcified LM disease. Further studies with a higher number of participants and longer follow-up times are warranted to establish the potential benefits of RA and S-IVL for the management of LM stenosis.

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Section: Discussionmentioning

confidence: 99%

Intravascular Lithotripsy as a Novel Treatment Method for Calcified Unprotected Left Main Diseases—Comparison to Rotational Atherectomy—Short-Term Outcomes

Rola

Kulczycki²,

Włodarczak

et al. 2022

IJERPH

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“…On the other hand, the NC balloon dilatation, in terms of eccentric calcium plaque, may direct the dilatation forces toward the non-calcified segments of the artery with a faint effect on calcium nodules. On the other hand, the S-IVL is a bulky device focused on the disruption of deep calcium plaque with the inability to cross through high-grade stenosis lesions [ 35 , 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

“…Although only one non-fatal subacute stent thrombosis occurred in our study cohort, and we did not observe any other rota-lithotripsy-related periprocedural complications, further studies are required in order to address the safety concerns. The use of RA increases the rate of thrombotic events, particularly slow flow phenomena [ 45 ], and some concerns raised recently regarding a higher tendency toward platelet aggregation following the implementation of shockwave therapy [ 35 ]. As result, future studies are necessary in order to evaluate these potential disadvantages in the subsequent use of RA and S-IVL.…”

Section: Discussionmentioning

confidence: 99%

Rota-Lithotripsy as a Novel Bail-Out Strategy for Highly Calcified Coronary Lesions in Acute Coronary Syndrome

Rola

Furtan

Włodarczak³

et al. 2022

Biomedicines

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Background: Heavily calcified lesions in acute coronary syndrome (ACS) still represent a challenging subset for percutaneous coronary intervention (PCI). Rota-lithotripsy—a marriage of rotational atherectomy and intravascular lithotripsy—has recently been introduced to clinical practice as a novel therapeutic option. Methods: This study is among the to present the 6-month clinical outcomes of rota-lithotripsy when performed in the ACS setting. The study cohort consisted of 15 consecutive ACS patients who underwent a rota-lithotripsy-PCI due to the presence of a highly calcified, undilatable lesion. Results: The procedural success ratio reached 100%. During the 6-month follow-up, in two of the patients, instances of MACE (major adverse cardiac events) occurred, including one fatal event. Additionally, during the observation period, one target lesion failure, due to subacute stent thrombosis, was identified. Conclusions: Rotational atherectomy with the subsequent use of shockwave intravascular lithotripsy appears to be a safe and effective therapeutic bail-out option for the management of highly calcified coronary artery lesions. Despite, these initial favorable outcomes, carrying out a large number of studies with long-term observations is still necessary in order to establish the potential benefits and shortcomings of rota-lithotripsy.

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“…ESWT mechanism of analgetic effect is probably assumed to be due to the lowering the concentration of substance-P that reduces the stimulation of afferent nociceptive fibres and thus reduces the pain (Rola et al, 2022;Hausdorf et al, 2004), overstimulation of pain nerve fibre endings (Melzack, 1975;Rompe, 1996), or disruption of the tendon tissue by the physical effects of the sound waves (or radial shock wave) resulting in induction of a healing process of the tendon (Loew, 1997).…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study on the Effect of Extracorporeal Shock Wave Therapy and Interferential Electrotherapy in Periarthritis Humeroscapularis

Stefanova¹,

Angelcheva²,

Bogdanova³

2022

Proceeding Book Vol.2

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Introduction: Periarthritis humeroscapularis is one of the most common causes of pain in the shoulder joint. The most applied treatment is conservative. Physical therapy and therapeutic modalities are effective, but there is uncertainty about their optimal combination. Objective: To examine whether the addition of either extracorporeal shock wave therapy or interferential electrotherapy to physical therapy of shoulder would be more effective in the management of periarthritis humeroscapularis. Materials and Methods: A total of 35 subjects with periarthritis humeroscapularis were divided into Group-A and Group-B. Both groups received 10 sessions of shoulder exercises and either extracorporeal shock wave therapy (Group-A) or interferential electrotherapy (Group-B). The outcome measures represent the American Shoulder and Elbow Surgeons Shoulder Score - the patient self-evaluation section (pain and activities of daily living) and the clinical assessment section (active and passive range of motion, strength, and stability). Results: Subjects showed statistically significant differences in reducing pain, improving range of motion and functional disability in the pre and post values of both the extracorporeal shock wave therapy and interferential electrotherapy groups. Group A was superior in improving external rotation ROM from abduction and flexion and Group B in alleviating pain. Conclusion: Either extracorporeal shock wave therapy or interferential electrotherapy in combination with physical therapy seemed to be significantly effective in the management of patients of periarthritis humeroscapularis. However, the group who received interferential electrotherapy showed higher improvement in pain, and the group with extracorporeal shock wave therapy demonstrated higher improvement in range of motion.

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Use of the Shock Wave Therapy in Basic Research and Clinical Applications—From Bench to Bedsite

Cited by 18 publications

References 93 publications

Intravascular Lithotripsy as a Novel Treatment Method for Calcified Unprotected Left Main Diseases—Comparison to Rotational Atherectomy—Short-Term Outcomes

Intravascular Lithotripsy as a Novel Treatment Method for Calcified Unprotected Left Main Diseases—Comparison to Rotational Atherectomy—Short-Term Outcomes

Rota-Lithotripsy as a Novel Bail-Out Strategy for Highly Calcified Coronary Lesions in Acute Coronary Syndrome

A Comparative Study on the Effect of Extracorporeal Shock Wave Therapy and Interferential Electrotherapy in Periarthritis Humeroscapularis

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