Use of the Probiotic Bifidobacterium animalis subsp. lactis HN019 in Oral Diseases

Abstract

The oral cavity is one of the environments on the human body with the highest concentrations of microorganisms that coexist harmoniously and maintain homeostasis related to oral health. Several local factors can shift the microbiome to a pathogenic state of dysbiosis. Existing treatments for infections caused by changes in the oral cavity aim to control biofilm dysbiosis and restore microbial balance. Studies have used probiotics as treatments for oral diseases, due to their ability to reduce the pathogenicity of the microbiota and immunoinflammatory changes. This review investigates the role of the probiotic Bifidobacterium animalis subsp. lactis (B. lactis) HN019 in oral health, and its mechanism of action in pre-clinical and clinical studies. This probiotic strain is a lactic acid bacterium that is safe for human consumption. It mediates bacterial co-aggregation with pathogens and modulates the immune response. Studies using B. lactis HN019 in periodontitis and peri-implant mucositis have shown it to be a potential adjuvant treatment with beneficial microbiological and immunological effects. Studies evaluating its oral effects and mechanism of action show that this probiotic strain has the potential to be used in several dental applications because of its benefit to the host.

Green tea extracts alleviate acetic acid‐induced oral inflammation and reconstruct oral microbial balance in mice

“…The trend was reversed upon administration of the high‐dose GTE, as it fostered the proliferation of Lactobacillus and Bacillus while concurrently suppressing Burkholderiales . Researches showed that Lactobacillus and Bacillus were generally gram‐positive bacteria, whereas the Burkholderiales order contained four families of gram‐negative bacteria (Araujo et al., 2022; Sim et al., 2010; Zhao & Kuipers, 2016). Figure 5d displays the functional predictions of the oral microbiota via analyzing the cluster of orthologous group database.…”

“…Oral microorganisms, such as Streptococcus mutans and Aggregatibacter actinomycetemcomitans , contributed to the pathogenesis of dental caries, periodontitis, and other oral diseases, and were associated with laryngeal cancer (Li et al., 2022; Peng et al., 2022; Simón‐Soro & Mira, 2015; Wang et al., 2019). In addition, every day about 600 mL of saliva rich in oral microbe is swallowed through the aerodigestive tract (Araujo et al., 2022). Imbalances in the oral microbiota may lead to disruption of the gut microbiome, which in turn induced inflammation and systemic changes (Iwauchi et al., 2019; Xu et al., 2021).…”

“…The oral cavity, harboring extensive and diverse microorganisms, is one of the most densely microbial colonized environments in the human body (Araujo et al., 2022). The oral microbiota plays a crucial role in maintaining health.…”

Fenofibrate positively affects gene expression profiles and metabolic pathway of high-fat diet-treated hamsters gut microbiota

“…Through its metabolism, it can produce a bene cial metabolite called Nmethylserotonin, which has been shown to promote weight loss, reduce fat accumulation, and enhance intestinal transit (Han et Bi dobacterium animalis belongs to the Bi dobacterium genus, which is widely recognized as a physiologically bene cial bacterium with various important functions for human health. These functions include acting as a biological barrier, providing nutritional bene ts, exhibiting anti-tumor effects, enhancing immune activity, improving gastrointestinal function, and promoting anti-aging effects (Araujo et al 2022). Supplementation with Bi dobacterium has been shown to prevent obesity and hyperlipidemia in mice with diet-induced obesity.…”

Managing Oral Health in the Context of Antimicrobial Resistance

“…A growing amount of evidence has been showing that Lactobacillus and Bifidobacterium strains can alter subgingival biofilms and modulate the immunoinflammatory response, leading to improved periodontal health [ 138 , 139 , 140 ]. Very recently, Wu and collaborators [ 140 ] showed, through metagenomic sequencing, that Lactobacillus paracasei L9 and Bifidobacterium animalis A6 proportionate a significant modification on the taxonomic composition of the subgingival microbiome, by reducing the relative proportions of pathogenic bacterial genera, such as Streptococcus , Fusobacterium , Veillonella , and Escherichia ; overall, they recommended additional research to be conducted to explore the promising use of these two probiotics as prophylactic agents for periodontitis.…”