Use of the ‘nutriceutical’, bovine colostrum, for the treatment of distal colitis: results from an initial study

Khan, Zubair; Macdonald, Christopher; Wicks, A. C. B.; Holt, M. P.; Floyd, David N.; Ghosh, Subrata; Wright, Nicholas; Playford, Raymond J.

doi:10.1046/j.1365-2036.2002.01354.x

Cited by 84 publications

(66 citation statements)

References 16 publications

(22 reference statements)

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“…The use of "natural" products, such as this colostral preparation, has several potential advantages. We have previously shown that they possess greater intrinsic stability against luminal digestion than isolated individual peptides (8) and that combination therapy with peptides provides the potential for the stimulation of gut stabilization or healing in a synergistic fashion (7). Furthermore, there is currently a demand from the general public for more natural types of products, which are usually considered as "alternative therapy," but which can possess potent biological activity.…”

Section: Discussionmentioning

confidence: 99%

The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes

Marchbank

Davison

Oakes

et al. 2011

American Journal of Physiology-Gastrointestinal and Liver Physi

130

155

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Heavy exercise causes gut symptoms and, in extreme cases, "heat stroke" partially due to increased intestinal permeability of luminal toxins. We examined bovine colostrum, a natural source of growth factors, as a potential moderator of such effects. Twelve volunteers completed a double-blind, placebo-controlled, crossover protocol (14 days colostrum/placebo) prior to standardized exercise. Gut permeability utilized 5 h urinary lactulose-to-rhamnose ratios. In vitro studies (T84, HT29, NCM460 human colon cell lines) examined colostrum effects on temperature-induced apoptosis (active caspase-3 and 9, Bax␣, Bcl-2), heat shock protein 70 (HSP70) expression and epithelial electrical resistance. In both study arms, exercise increased blood lactate, heart rate, core temperature (mean 1.4°C rise) by similar amounts. Gut hormone profiles were similar in both arms although GLP-1 levels rose following exercise in the placebo but not the colostrum arm (P ϭ 0.026). Intestinal permeability in the placebo arm increased 2.5-fold following exercise (0.38 Ϯ 0.012 baseline, to 0.92 Ϯ 0.014, P Ͻ 0.01), whereas colostrum truncated rise by 80% (0.38 Ϯ 0.012 baseline to 0.49 Ϯ 0.017) following exercise. In vitro apoptosis increased by 47-65% in response to increasing temperature by 2°C. This effect was truncated by 60% if colostrum was present (all P Ͻ 0.01). Similar results were obtained examining epithelial resistance (colostrum truncated temperature-induced fall in resistance by 64%, P Ͻ 0.01). Colostrum increased HSP70 expression at both 37 and 39°C (P Ͻ 0.001) and was truncated by addition of an EGF receptor-neutralizing antibody. Temperature-induced increase in Bax␣ and reduction in Bcl-2 was partially reversed by presence of colostrum. Colostrum may have value in enhancing athletic performance and preventing heat stroke.repair; gut growth; injury; clinical trial SEVERAL STRESSES AFFECT the integrity of the intestinal barrier. These include prolonged strenuous exercise (10), heat stress (11), and drugs such as nonsteroidal anti-inflammatory agents. Loss of intestinal barrier integrity leading to increased intestinal permeability may result in passage of luminal endotoxins into the circulation. This, in turn, results in an inflammatory cascade, exacerbating the loss of barrier function and, in severe cases, resulting in severe systemic effects.Severe cases of decompensation can result in the lifethreatening condition of exertional heat stroke, associated with hyperthermia, multiorgan failure, and endotoxemia. In addition, it is increasingly recognized that similar processes have relevance for many athletes involved in heavy exercise such as long-distance running. Gastrointestinal symptoms including cramps, diarrhea, nausea, and bleeding are commonly reported by long-distance runners (16). These symptoms are likely to be due to a combination of reduced splanchnic blood flow, hormonal changes, altered gut permeability, and increased body temperature.Pharmacological options to reduce these problems are limited, particularly in compe...

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Section: Discussionmentioning

confidence: 99%

The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes

Marchbank

Davison

Oakes

et al. 2011

American Journal of Physiology-Gastrointestinal and Liver Physi

130

155

View full text Add to dashboard Cite

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“…In other species bovine colostrum has been demonstrated to improve gut restoration. Giving orally, bovine colostrum prevents chemically-induced villous atrophy in mice (Playford et al, 1999) and stimulates mucosal healing of patients suffering from inflammatory gut disease (Khan et al, 2002). Our studies aim at evaluating effects of bovine colostrum on gut restoration in weaned piglets.…”

Section: Introductionmentioning

confidence: 99%

Influence of bovine colostrum on restoration of intestinal mucosa in weaned piglets

et al. 2007

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“…These beneficial effects could be explained by both an observed increase in feed intake level as early as the first days after weaning [1] and a likely direct effect on gut health. Giving bovine colostrum orally prevents chemically-induced villous atrophy in mice [3] and stimulates mucosal healing of patients suffering from inflammatory gut disease [4]. It reduces diarrhoeal symptoms in infants [5] and protects intestinal mucosa from pathogen bacteria adhesion [6].…”

Section: Introductionmentioning

confidence: 99%

Effects of a bovine colostrum-supplemented diet on some gut parameters in weaned piglets

et al. 2006

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-The present study investigated the effects of a bovine colostrum-supplemented diet on gut post-weaning adaptation and health in piglets. Thirty-six 21-d-old piglets were allocated to one of the three following dietary treatments: sow-reared (SR), weaned on a control starter diet (WCtrl) or on a starter diet supplemented with bovine colostrum (WCol) until slaughter at 28 d or 35 d of age. Gastric pH and intestinal bacteriological, structural and functional parameters were determined. Compared to WCtrl, the gastric pH was lower (P < 0.05) and the duodenal lactobacilli:coliform ratio was higher (P = 0.05) in WCol piglets. The relative small intestine weight was 18% (P < 0.05) higher in WCol piglets than in SR piglets. Duodenal villous height was lower (P < 0.01) in WCtrl than in SR piglets, whereas the value for WCol piglets was intermediate. The weaning-increased crypt cell proliferation was not affected by bovine colostrum supplementation. The mucosal ribosomal capacity was higher (P < 0.05) in W than in SR piglets. In conclusion, a diet supplemented with colostrum induced, although not always significantly, variations of gut parameters, suggesting that globally, colostrum may limit weaning-induced gut structural and microbial alterations. The observed effects occurred early and were maintained throughout the post-weaning adaptive phase. bovine colostrum / intestine / microflora / mucosa growth / weaning

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Use of the ‘nutriceutical’, bovine colostrum, for the treatment of distal colitis: results from an initial study

Cited by 84 publications

References 16 publications

The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes

The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes

Influence of bovine colostrum on restoration of intestinal mucosa in weaned piglets

Effects of a bovine colostrum-supplemented diet on some gut parameters in weaned piglets

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