Use of the ninhydrin assay to measure the release of chitosan from oral solid dosage forms

Leane, Michael; Nankervis, R.; Smith, Alan M.; Illum, Lisbeth

doi:10.1016/j.ijpharm.2003.11.023

Cited by 101 publications

(72 citation statements)

References 20 publications

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“…Based on Figure 1.4, the zero-charge points of CS macromolecules, PNIAA microparticles and CM complexes are determined to be 6.3, 3.4 and 6.0, respectively. The value for CS is similar to bibliographic values of CS pK a (6.3-6.6) (Leane et al 2004; nm, whereas that of PNIAA microparticles, under the same nm. The fact that PNIAA microparticles exhibit a somewhat smaller Rinaudo et al 1999).…”

Section: Microgel Cm: Complexes Morphology and Chargesupporting

confidence: 84%

“…It is derived by deacetylation from chitin, a structural compound of crustacean shells and fungi (Limam et al 2011;Al Sagheer et al 2009;Tajdini et al 2010;Wang et al 2008). Owing to its multiple deacetylated, therefore primary, amine groups, chitosan is a pH-responsive biopolymer with reported pK a * values of 6.2-6.6 (Leane et al 2004;Phillips et al 2000;Prochazkova et al 1999). It is widely used in dietary products, health care systems, waste processing, as well as in the textile industry for e.g.…”

Section: Chitosan N-isopropylacrylamide Acrylic Acidmentioning

confidence: 99%

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Advanced microgel-functionalized polyester textiles adaptive to ambient conditions

Glampedaki¹

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Section: Microgel Cm: Complexes Morphology and Chargesupporting

confidence: 84%

Section: Chitosan N-isopropylacrylamide Acrylic Acidmentioning

confidence: 99%

Advanced microgel-functionalized polyester textiles adaptive to ambient conditions

Glampedaki¹

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“…The released samples were withdrawn at 3, 7, 14, 21, 28, 35 d. The ninhydrin assay was used to measure the chitosan release in vitro. 17,18) Brie‰y, 0.5 ml sample was added to 0.5 ml freshly prepared ninhydrin reagent (pH 5.2). Then the solution was placed under the boiling water bath for 30 min and 15 ml ethanol-water (1 : 1, v/v) was added after being cold to room temperature.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of Daidzein-loaded Chitosan Microspheres <i>In Vivo</i> after Intramuscular Injection in Rats

Mei

Liu

2011

YAKUGAKU ZASSHI

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Daidzein-loaded chitosan microspheres were prepared by emulsiˆcation/chemical-crosslinking technique. The dialysis bag method determined the release of daidzein from the microspheres. It demonstrated that the accumulative release curve in vitro wasˆt for the zero-order release equation and had good correlation with the absorptive fraction in vivo, suggesting the dialysis bag method evaluated the release of the microspheres well. The release of chitosan determined by the ninhydrin assay in vitro was very slow, less than 3 percent at 35 day. The pathological section by hematoxylin-eosin staining found the good biocompatibility of the prepared microspheres in the injective site. Combining the degradation photos by scanning electron microscopy with the plasma concentration-time data, it was speculated that the drug on the surface of the microspheresˆrstly released, then the major of drug near the surface and the inner of the microspheres released by diŠusion through the shallow cavities and crack, lastly the drug released rapidly and completely being companied with the beginning of polymer degradation.

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“…[39][40][41][42][43][44][45] Ninhydrin is extensively used to detect compounds of pharmaceutical importance [46][47][48][49][50][51][52][53][54][55][56][57] and in kinetic studies. [58][59] Scheme 1.…”

Section: -10mentioning

confidence: 99%

Ninhydrin in synthesis of heterocyclic compounds

Ziarani¹,

Lashgari²,

Azimian³

et al. 2015

Arkivoc

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Ninhydrin has been utilized in many heterocyclic preparations and considered as an important building block in organic synthesis. There is a wide range of reactions that include ninhydrin in the synthesis of heterocyclic compounds. This review highlights the advances in the use of ninhydrin as starting material in the synthesis of various organic compounds and drugs in a fully comprehensive way, from its first isolation in 1910 to the end of 2013. There is also a diversity of multi-component reactions of ninhydrin and we highlight the recent reports in this review.

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Use of the ninhydrin assay to measure the release of chitosan from oral solid dosage forms

Cited by 101 publications

References 20 publications

Advanced microgel-functionalized polyester textiles adaptive to ambient conditions

Advanced microgel-functionalized polyester textiles adaptive to ambient conditions

Evaluation of Daidzein-loaded Chitosan Microspheres <i>In Vivo</i> after Intramuscular Injection in Rats

Ninhydrin in synthesis of heterocyclic compounds

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