Progress in neurosurgery has paralleled technological innovation. Image-guided surgical robotic systems have emerged as a potential hub for integration of the complex sensory, pathologic, and imaging data sets that are available to contemporary neurosurgeons. These systems couple the executive capacity of surgeons with the technical capabilities of machines and have the potential to improve surgical care as neurosurgery progresses towards the cellular level. Surgery is often performed in animal models prior to clinical application, representing a very important safety step in regulatory approval. As the capital investment for surgical robotic systems decreases, robotic systems may be specifi cally designed for animal application. In this chapter, we review neurosurgical robotic systems used in humans and animals; present the development, preclinical testing, and early clinical use of a unique image guided MR-compatible neurosurgical robot called neuroArm; and review the strengths and limitations of using surgical robotic systems in animal models.