2002
DOI: 10.1056/nejmoa011327
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Use of the Low-Molecular-Weight Heparin Reviparin to Prevent Deep-Vein Thrombosis after Leg Injury Requiring Immobilization

Abstract: Deep-vein thrombosis is common in persons with leg injury requiring prolonged immobilization. Reviparin given once daily appears to be effective and safe in reducing the risk of this complication.

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Cited by 178 publications
(173 citation statements)
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“…Comparison with others is, however, difficult since previous randomized studies (Kujath et al 1993, Kock et al 1995, Jorgensen et al 2002, Lassen et al 2002 have included a heterogeneous mix of patients with different lower limb injuries, treated with or without surgery, factors that may influence the effect of the thromboprophylaxis given and the risk of DVT (Geerts et al 2004). Only 1 of the previous studies (Lassen et al 2002) was placebo-controlled and phlebography was mandatory in only 2 of these studies (Jorgensen et al 2002, Lassen et al 2002. Kujath et al (1993) and Kock et al (1995) used unblinded treatment, and ultrasound to screen for DVT.…”
Section: Discussionmentioning
confidence: 99%
“…Comparison with others is, however, difficult since previous randomized studies (Kujath et al 1993, Kock et al 1995, Jorgensen et al 2002, Lassen et al 2002 have included a heterogeneous mix of patients with different lower limb injuries, treated with or without surgery, factors that may influence the effect of the thromboprophylaxis given and the risk of DVT (Geerts et al 2004). Only 1 of the previous studies (Lassen et al 2002) was placebo-controlled and phlebography was mandatory in only 2 of these studies (Jorgensen et al 2002, Lassen et al 2002. Kujath et al (1993) and Kock et al (1995) used unblinded treatment, and ultrasound to screen for DVT.…”
Section: Discussionmentioning
confidence: 99%
“…[6,[8][9][10][11][12][13][14][15][16][17][18][19][20]26,37,41] A difficulty of long-term follow-up of patients is that many DVT events occur several weeks or longer after discharge. [37,42] …”
Section: Researchmentioning
confidence: 99%
“…The risk of thromboembolism after acute achillies tendon rupture has been demonstrated in several studies [4][5][6]. Venous thromboembolism was demonstrated in 34% patients, two months after an acute total Achilles tendon rupture [2].…”
Section: Discussionmentioning
confidence: 95%