Use of the impulse oscillometry system for testing pulmonary function during methacholine bronchoprovocation in horses

Erck, Emmanuelle Van; Votion, Dominique; Kirschvink, Nathalie; Art, Tatiana; Lekeux, Pierre

doi:10.2460/ajvr.2003.64.1414

Cited by 28 publications

(21 citation statements)

References 30 publications

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“…Histamine challenge score also produced the highest proportion of correctly classified horses (coughing and nasal discharge groups) in discriminant analysis. Histamine bronchoprovocation revealed significant differences between healthy control horses and the group of RAO‐affected horses with neither owner‐reported coughing nor nasal discharge, and also demonstrated the most consistent differences between the healthy control horses and all the RAO‐affected groups, confirming observations from experimental studies which have shown that RAO‐affected horses kept in a low‐dust indoor environment will continue to show airway hyperresponsiveness , in contrast to those kept permanently on pasture ). Several studies on human asthma have shown that airway hyperresponsiveness persists in many individuals who consider themselves to be in remission of asthma .…”

Section: Discussionsupporting

confidence: 76%

Owner‐reported coughing and nasal discharge are associated with clinical findings, arterial oxygen tension, mucus score and bronchoprovocation in horses with recurrent airway obstruction in a field setting

Rettmer

Hoffman

Lanz

et al. 2014

Equine Veterinary Journal

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Owner-reported coughing and nasal discharge are associated with specific clinical and diagnostic findings in RAO-affected horses in field settings. While airway hyperresponsiveness differentiates best between healthy horses and asymptomatic RAO-affected horses, the absence of coughing and nasal discharge does not rule out significant neutrophilic airway inflammation. Owner satisfaction with the clinical status of the horse was uninformative.

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Section: Discussionsupporting

confidence: 76%

Owner‐reported coughing and nasal discharge are associated with clinical findings, arterial oxygen tension, mucus score and bronchoprovocation in horses with recurrent airway obstruction in a field setting

Rettmer

Hoffman

Lanz

et al. 2014

Equine Veterinary Journal

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“…As previously reported, the horses studied during phase 1 underwent IOS testing before and after sedation . The R 5 : R 10 ratio has been validated previously as an indicator of airway obstruction in horses with heaves . The resonant frequency indicates the frequency at which the inflation pressure and elastic recoil cancel out, resulting in a reactance equal to zero.…”

Section: Discussionmentioning

confidence: 94%

Development of a Semiquantitative Histological Score for the Diagnosis of Heaves Using Endobronchial Biopsy Specimens in Horses

Bullone

Hélie

Joubert

et al. 2016

Veterinary Internal Medicne

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BackgroundRemodeling of the peripheral airways persists during the asymptomatic phase of heaves. Assessing the histology of large bronchi could facilitate the diagnosis of heaves during remission of the disease.HypothesisAirway inflammation and remodeling in endobronchial biopsy (EBB) specimens differentiate horses with heaves from controls, independently of their clinical status (exacerbation or remission).AnimalsFourteen healthy horses and 24 horses with heaves.MethodsA 14‐point scoring system assessing central bronchial wall inflammation and remodeling was developed. The score was validated by 2 pathologists using specimens obtained from 18 horses (6 controls, 6 with heaves exacerbation, and 6 with heaves remission) in which lung function had been assessed with impulse oscillometry. Clinical and research application of the score was evaluated using biopsy specimens obtained from 20 additional horses (8 controls, 6 with heaves exacerbation, and 6 with heaves remission).ResultsThe score was repeatable (interclass correlation coefficient = 69%). It differentiated horses with heaves in exacerbation (mean ± SD: 6.2 ± 2.2) from those in remission (4.0 ± 1.0) and controls (3.6 ± 1.7, P < 0.0001). The histological scores of horses with heaves correlated with the ratio of respiratory resistance (R) at 5 and 10 Hz (R 5 : R 10 ratio, r = 0.65, P = 0.03), a parameter assessing airway obstruction.Conclusions and Clinical SignificanceThe proposed histological scoring system correlates with the degree of airway obstruction measured by impulse oscillometry. However, it does not discriminate horses with heaves in remission from controls. Evaluation of EBB specimens might be considered in future research and clinical studies of respiratory diseases in horses.

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“…Consequently, alternative more sensitive methods have been evaluated in recent years. These include impulse oscillometry, which measures respiratory resistance and reactance at various frequencies , tidal breathing flow‐volume loops , volumetric capnography and forced expiratory flow‐volume curve analysis , with the most discriminatory and commonly employed method at present being impulse oscillometry.…”

Section: Ancillary Diagnostic Testsmentioning

confidence: 99%

Recurrent airway obstruction: A review

Pirie

2014

Equine Veterinary Journal

107

115

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Recurrent airway obstruction is a widely recognised airway disorder, characterised by hypersensitivity-mediated neutrophilic airway inflammation and lower airway obstruction in a subpopulation of horses when exposed to suboptimal environments high in airborne organic dust. Over the past decade, numerous studies have further advanced our understanding of different aspects of the disease. These include clarification of the important inhaled airborne agents responsible for disease induction, improving our understanding of the underlying genetic basis of disease susceptibility and unveiling the fundamental immunological mechanisms leading to establishment of the classic disease phenotype. This review, as well as giving a clinical overview of recurrent airway obstruction, summarises much of the work in these areas that have culminated in a more thorough understanding of this debilitating disease.

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Use of the impulse oscillometry system for testing pulmonary function during methacholine bronchoprovocation in horses

Abstract: In contrast to CRT parameters, IOS parameters were significantly more sensitive for testing pulmonary function. The IOS provides a practical and noninvasive pulmonary function test that may be useful in assessing subclinical changes in horses.

Cited by 28 publications

References 30 publications

Owner‐reported coughing and nasal discharge are associated with clinical findings, arterial oxygen tension, mucus score and bronchoprovocation in horses with recurrent airway obstruction in a field setting

Owner‐reported coughing and nasal discharge are associated with clinical findings, arterial oxygen tension, mucus score and bronchoprovocation in horses with recurrent airway obstruction in a field setting

Development of a Semiquantitative Histological Score for the Diagnosis of Heaves Using Endobronchial Biopsy Specimens in Horses

Recurrent airway obstruction: A review

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