Use of technetium-99m sestamibi ECG-gated single-photon emission tomography for the evaluation of left ventricular function following coronary artery bypass graft: comparison with three-dimensional magnetic resonance imaging

Abstract

In patients who had undergone cardiac surgery (coronary artery bypass graft) and whose hearts showed abnormal movement during the cardiac cycle, we studied the accuracy of functional assessment using ECG-gated single-photon emission tomography (SPET) and the automated software developed by Germano et al. by comparing the findings with magnetic resonance (MR) images acquired three-dimensionally. Sixteen patients who had undergone cardiac surgery underwent 99mTc-sestamibi gated SPET (MIBI-g-SPET) and MRI on the same day. Left ventricular end-diastolic and end-systolic volumes (EDV, ESV) and ejection fraction (LVEF) were measured using MIBI-g-SPET and the aforementioned algorithm. Regional wall thickening was assessed using a four-point scale on MIBI-g-SPET and cine MRI. There was a good correlation between MIBI-g-SPET and MRI in respect of EDV (r=0.89), ESV (r=0.93) and LVEF (r=0.89). A high degree of agreement was found between the wall thickening scores obtained by MIBI-g-SPET and MRI in total segments (kappa=0.62) and in septal segments (kappa=0.67). It is concluded that ECG-gated perfusion SPET can provide regional and global functional information, including absolute volumes, in patients following cardiac surgery.

Absolute Quantification of Left Ventricular Global and Regional Function at Nuclear MPI Using Ultrafast CZT SPECT: Initial Validation Versus Cardiac MR

“…This study demonstrates excellent agreement between CZT SPECT and cardiac MR for the measurement of EF. An underestimation of EF by MPI SPECT using QGS analysis has been consistently reported in previous studies using standard dual-detector cameras (26)(27)(28)(29)(30)(31)(32)(33). Our results suggest that CZT SPECT cameras might be more accurate, with a minimal systematic bias (22.7%) that might have limited clinical relevance.…”

Measurement of left ventricular volumes and ejection fraction by quantitative gated SPET, contrast ventriculography and magnetic resonance imaging: a meta-analysis

“…However, validation studies of QGS in assessing LV function have used only reference methods with limited accuracy [3,4,5,6,7]. Although other studies have used more reliable reference methods, such as contrast left ventriculography (LVG) [8,9,10,11] or magnetic resonance imaging (MRI) [12,13,14,15,16,17], all were based on data from relatively few patients, and uncertainty as to the accuracy of QGS has remained. We therefore performed a meta-analysis of all known data comparing QGS with LVG and with MRI.…”

Left Ventricular Functional Analysis Using 64-Slice Multidetector Row Computed Tomography: Comparison with Left Ventriculography and Cardiovascular Magnetic Resonance

“…The resultant temporal resolution of 21–42 ms was provided according to the individual heart rate. Cine MR images of 10–12 contiguous sections, 8 mm thick, with an interslice gap of 2 mm were obtained in the short-axis planes, covering the entire left ventricle from the base to the apex, to acquire 3-dimensional LV data [15,16,17]. In addition, cine MR images were acquired in the vertical and horizontal long-axis planes.…”