Use of systemic glucocorticoids and the risk of colorectal cancer

Ostenfeld, Eva Bjerre; Erichsen, Rune; Thorlacius-Ussing, Ole; Riis, Anders H.; Sørensen, Henrik Toft

doi:10.1111/apt.12115

Cited by 22 publications

(13 citation statements)

References 24 publications

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“…We excluded patients who developed malignancy before CST administration in the evaluation between malignancy and CST. The following eight variables were evaluated in 68 patients receiving CST during follow-up: (1) period of CST (<6 versus >6 months), (2) period of CST (<3 versus >3 years), (3) CST without cessation from diagnosis, (4) cumulative period of CST until development of malignancy, (5) cumulative amount of CST until development of malignancy, (6) cumulative period of CST during follow-up, (7) cumulative amount of CST during follow-up and (8) follow-up period.…”

Section: Methodsmentioning

confidence: 99%

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Correlation between long-term outcome and steroid therapy in type 1 autoimmune pancreatitis: relapse, malignancy and side effect of steroid

Shimizu

Naitoh

Nakazawa

et al. 2015

Scandinavian Journal of Gastroenterology

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Section: Methodsmentioning

confidence: 99%

“…However, it has not been clarified whether patients with IgG4-RD are at high risk for developing a malignancy. CST is a risk factor to develop malignancy [7][8][9][10][11][12]. The associations between CST and malignancies in the IgG4-RD or AIP populations have not been reported to date.…”

Section: Introductionmentioning

confidence: 99%

Correlation between long-term outcome and steroid therapy in type 1 autoimmune pancreatitis: relapse, malignancy and side effect of steroid

Shimizu

Naitoh

Nakazawa

et al. 2015

Scandinavian Journal of Gastroenterology

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“…This case-controlled study suggested that not only aspirin but also other drugs may be effective chemopreventative agents for colorectal cancer. Some drugs, such as Ca-channel blockers and steroids, had no such effect in previous studies (32,39,40). As these previous studies were retrospective analyses, they could have been affected by bias.…”

Section: Discussionmentioning

confidence: 95%

“…In this study, only 7 patients received calcium by prescription and it was not significantly associated with colorectal cancer prevention. Many of the remaining hits in this study have been previously assessed for colorectal cancer preventative effects, including vitamin B, vitamin C, vitamin E, folic acid, bisphosphonates, Ca-channel blockers, ARB, thienopyridine, nitrovasodilators, probiotics, statins, and steroids (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32). Vitamin B, vitamin C, vitamin E, folic acid, bisphosphonates, and probiotics may have some colorectal cancer preventive effects, although the evidence is not yet strong.…”

Section: Discussionmentioning

confidence: 99%

Alpha-Blockers As Colorectal Cancer Chemopreventive: Findings from a Case–Control Study, Human Cell Cultures, and In Vivo Preclinical Testing

Suzuki

Niikura

Ihara

et al. 2019

Cancer Prevention Research

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A retrospective case-controlled analysis was performed to identify drug candidates in the current use that may prevent colorectal cancer, outside of aspirin. A total of 37,510 patients aged !20 years were assessed to identify subjects who had been diagnosed with colorectal cancer by colonoscopy without a previous diagnosis of colorectal cancer, inflammatory bowel disease (IBD), or gastrointestinal symptoms; 1,560 patients were identified who were diagnosed with colorectal cancer by colonoscopy. The patients with colorectal cancer were matched with 1,560 age, gender, family history of colorectal cancer and comorbidity-matched control patients who were not diagnosed with colorectal cancer at colonoscopy. The medication histories were compared between the two groups. Next, candidate drugs that were more frequently used by the control patients were selected and their effects on human colorectal cancer cell lines in vitro and an inflammation-induced mouse model of colorectal cancer were tested. Putative colorectal cancer preventative agents were identified, including aspirin, vitamin D, vitamin B, vitamin C, vitamin E, xanthine oxidase inhibitor, alpha-blockers, angiotensin receptor blocker, nateglinide, probiotics, thienopyridine, folic acid, nitrovasodilators, bisphosphonates, calcium channel blockers, steroids, and statins (P < 0.05). Alphablockers and xanthine oxidase inhibitors were selected for further study because these agents have not been analyzed previously as factors that may affect colorectal cancer outcomes. In vitro doxazosin (alpha-blocker), but not febuxostat (xanthine oxidase inhibitor), suppressed the proliferation of human colorectal cancer cells. Doxazosin also decreased tumorigenesis in an AOM/DSS mouse colorectal cancer model. Alpha-blockers may prevent colorectal cancer.

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“…It may occur sporadically or in association with neurofibromatosis type 2 (NF2) [2]. Approximately 120 cases of MA have been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

Multicystic meningioangiomatosis

Cui

Wang

et al. 2014

BMC Neurol

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BackgroundMeningioangiomatosis (MA) is a rare hamartomatous lesion. Only six cases of cystic MA have been reported in the literature.Case presentationWe present a case of multicystic MA. A 21-year-old woman without any stigmata of neurofibromatosis type 2 presented with intractable seizures since 10 years. Brain magnetic resonance imaging revealed a well-defined, multicystic mass with heterogeneous signal intensity in the right temporal lobe. The patient underwent resection of the lesion and of the epileptogenic cortex under intraoperative electrocorticography (ECoG) assistance. Histopathological examination showed proliferation of perivascular cells that were arranged in a cuff pattern and were positive for vimentin, D2-40 and smooth muscle actin. Mutiple microcysts and enlarged perivascular spaces were present, which was similar to the structure of the arachnoid cavity. Hyalinized collagen fibers with round concentric acellular eosinophilic lamellae within areas of reactive gliosis were noted for the first time in MA. The patient was followed up without any clinical symptoms or recurrence for 2 years.ConclusionMA may originate from arachnoid and vascular tissue trapped in the cortical parenchyma during brain development, and the cysts may have resulted from the gradual accumulation of cerebrospinal fluid in the perivascular spaces of the trapped tissue. Resection of the lesion and of the epileptogenic cortex is important not only for pathological diagnosis but also for seizure control, and intraoperative ECoG assistance is recommended.

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Use of systemic glucocorticoids and the risk of colorectal cancer

Abstract: SUMMARY BackgroundSystemic glucocorticoids are potent immunosuppressants, potentially facilitating carcinogenesis. Studies examining glucocorticoids and colorectal cancer risk are few.

Cited by 22 publications

References 24 publications

Correlation between long-term outcome and steroid therapy in type 1 autoimmune pancreatitis: relapse, malignancy and side effect of steroid

Correlation between long-term outcome and steroid therapy in type 1 autoimmune pancreatitis: relapse, malignancy and side effect of steroid

Alpha-Blockers As Colorectal Cancer Chemopreventive: Findings from a Case–Control Study, Human Cell Cultures, and In Vivo Preclinical Testing

Multicystic meningioangiomatosis

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