Use of Strips Containing Tetracycline Hydrochloride or Metronidazole for the Treatment of Advanced Periodontal Disease

Deasy, P. B.; Collins, Augusta E. M.; MacCarthy, Denise; Russell, R.J.

doi:10.1111/j.2042-7158.1989.tb06343.x

Cited by 64 publications

(38 citation statements)

References 15 publications

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“…Re-treatment of these same pockets with films after scaling and root planing showed further reductions in the pathological flora, but the changes were not significantly different from controls. Deasy et al (1989) studied the effects of tetracycline hydrochloride and metronidazole released from 0.5-mmthick films formed by the compacting of a 15-mg mixture of the drug and polyhydroxybutyric acid in an infrared press. The in vitro release rate of the drug depended on the drug load and the drug used.…”

Section: Types Of Devices Thatmentioning

confidence: 99%

Subgingival Delivery of Therapeutic Agents in the Treatment of Periodontal Diseases

Soskolne

1997

Critical Reviews in Oral Biology & Medicine

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This article reviews the current status of controlled local delivery of antibacterial agents in the treatment of periodontitis. The principle of local intrapocket delivery of antibacterial agents and their delivery are discussed. The dosage forms include fibers, film/slabs, and injectable systems, some of which are degradable, while others are not and need to be removed at the termination of the treatment. The antibacterial agents used cover a range of antibiotics as well as antiseptics, and the composition of the delivery systems, their reported use, and the clinical results are summarized. The use of these systems in clinical practice is relatively recent, and therefore their application and integration into the dental office are not yet clearly defined. Clinical applications that have been tested are critically reviewed, and clinical situations in which controlled delivery of antibacterial agents may prove to be clinically useful are suggested for scientific evaluation.

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Section: Types Of Devices Thatmentioning

confidence: 99%

Subgingival Delivery of Therapeutic Agents in the Treatment of Periodontal Diseases

Soskolne

1997

Critical Reviews in Oral Biology & Medicine

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“…Water molecules bind to the polymer carboxyl groups which are required for adhesion and swelling (36), and polymer chains are eroded in the long run. However, excessive swelling rate causes reduced mucoadhesion leading to fast erosion.…”

Section: Characterization Of Microparticlesmentioning

confidence: 99%

Study of the Mucoadhesive Potential of Carbopol Polymer in the Preparation of Microbeads Containing the Antidiabetic Drug Glipizide

2015

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Abstract. The present investigation was aimed at exploitation of the mucoadhesive potential of carbopol 934P polymer in developing microbeads of glipizide (GLP) for its effectivity in controlling blood sugar in diabetic patients. Various batches of GLP beads were prepared by an emulsion-solvent evaporation technique using the release-retarding polymer carbopol and subjected to a systematic evaluation such as physical characterization, ex vivo mucoadhesion, hydration and erosion test, and in vitro drug release; and instrumental and in vivo studies were performed with the best formulation. The highest yield and loading efficiency were observed as 94 and ∼90%, respectively. The mean particle size of the microbeads ranged from 832 to 742 μm. The oval shape of the microbeads with slight roughness was apparent in the SEM micrograph. The release period was extended till 18 h. In vitro release of the drug from the beads followed the diffusion and erosion mechanism. In the oral glucose tolerance test (OGTT), there is a significant (p<0.01) reduction in fasting blood glucose levels in Wistar rat and guinea pig in comparison with that using the marketed product. Results indicated that process parameters-drug-polymer ratio, concentration of the surfactant, and stirring speed-controlled the various characteristics of the microparticles. The mucoadhesivity test ensured strong adherence of the beads to the mucosal membrane in pH 1.2 for a prolonged period. Owing to the mucoadhesivity of carbopol 934P, prolonged release of GLP and reduction of fasting sugar in the animal model were observed to a satisfactory level, and thus, management of diabetes in a better manner is expected with this new formulation.

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“…The sol obtained had agreeable taste, syringability, was thermo reversible and provided controlled drug release by converting into gel in periodontal pocket (Kumari & Pathak, 2012). Deasy et al (1989) Another environment responsive system was developed by Dabhi and coworkers for delivery of metronidazole benzoate using poly-e-caprolactone an in situ precipitating polymer and carbopol 934P, a pH simulative polymer. An increase in viscosity and a delay in 50% and 90% drug release was experienced by enhancing the concentration of the polymers (Dabhi et al, 2010).…”

Section: Gelsmentioning

confidence: 99%

Advanced drug delivery approaches against periodontitis

et al. 2014

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Periodontitis is an inflammatory disease of gums involving the degeneration of periodontal ligaments, creation of periodontal pocket and resorption of alveolar bone, resulting in the disruption of the support structure of teeth. According to WHO, 10-15% of the global population suffers from severe periodontitis. The disease results from the growth of a diverse microflora (especially anaerobes) in the pockets and release of toxins, enzymes and stimulation of body's immune response. Various local or systemic approaches were used for an effective treatment of periodontitis. Currently, controlled local drug delivery approach is more favorable as compared to systemic approach because it mainly focuses on improving the therapeutic outcomes by achieving factors like site-specific delivery, low dose requirement, bypass of firstpass metabolism, reduction in gastrointestinal side effects and decrease in dosing frequency. Overall it provides a safe and effective mode of treatment, which enhances patient compliance. Complete eradication of the organisms from the sites was not achieved by using various surgical and mechanical treatments. So a number of polymer-based delivery systems like fibers, films, chips, strips, microparticles, nanoparticles and nanofibers made from a variety of natural and synthetic materials have been successfully tested to deliver a variety of drugs. These systems are biocompatible and biodegradable, completely fill the pockets, and have strong retention on the target site due to excellent mucoadhesion properties. The review summarizes various available and recently developing targeted delivery devices for the treatment of periodontitis.

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Use of Strips Containing Tetracycline Hydrochloride or Metronidazole for the Treatment of Advanced Periodontal Disease

Cited by 64 publications

References 15 publications

Subgingival Delivery of Therapeutic Agents in the Treatment of Periodontal Diseases

Subgingival Delivery of Therapeutic Agents in the Treatment of Periodontal Diseases

Study of the Mucoadhesive Potential of Carbopol Polymer in the Preparation of Microbeads Containing the Antidiabetic Drug Glipizide

Advanced drug delivery approaches against periodontitis

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