Use of stereolithography to manufacture critical‐sized 3D biodegradable scaffolds for bone ingrowth

Cooke, Malcolm N.; Fisher, John P.; Dean, David; Rimnac, Clare M.; Mikos, Antonios G.

doi:10.1002/jbm.b.10485

Cited by 496 publications

(303 citation statements)

References 18 publications

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“…The principle of this technique is based on the initiation of a chemical reaction (photopolymerization [216] or crosslinking [217]) in special polymer liquids by electromagnetic radiation. Light from a laser beam is directed onto selected regions of a layer of liquid polymer causing solidification in the exposed areas.…”

Section: Stereolithographic Working Principlesmentioning

confidence: 99%

Design and preparation of polymeric scaffolds for tissue engineering

Weigel

Schinkel

Lendlein

2006

Expert Review of Medical Devices

207

154

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Polymeric scaffolds for tissue engineering can be prepared with a multitude of different techniques. Many diverse approaches have recently been under development. The adaptation of conventional preparation methods, such as electrospinning, induced phase separation of polymer solutions or porogen leaching, which were developed originally for other research areas, are described. In addition, the utilization of novel fabrication techniques, such as rapid prototyping or solid free-form procedures, with their many different methods to generate or to embody scaffold structures or the usage of selfassembly systems that mimic the properties of the extracellular matrix are also described. These methods are reviewed and evaluated with specific regard to their utility in the area of tissue engineering.Expert Rev. Med. Devices 3(6), 835-851 (2006) The technology of tissue engineering aims to generate new or substitute damaged or malfunctioning tissue or organs and could well become an alternative method to whole organ transplantation [1][2][3][4][5][6]. In the last decade particularly, enormous advances have been made in the area of tissue regeneration for therapeutical purposes. Tissue engineering is an interdisciplinary research area in which principles of material science/engineering and cell biology/life science are combined. The methods of tissue engineering have been applied to different types of tissue, including skin [7][8][9][10][11], bone [12][13][14][15][16], liver [17][18][19][20][21], intestine [22][23][24][25][26][27], esophagus [28][29][30][31][32], valve leaflets [33][34][35][36], muscle [37][38][39] and tongue [40][41][42], the vascular system [43][44][45][46][47], for craniofacial defects [48][49][50], tendons and ligaments [51][52][53][54][55], cartilage [56][57][58][59][60] and nerve tissue [61][62][63][64][65]. Since the early commercialization of tissue-engineered applications, for example, the work of Bell and colleagues [66], research with stem cells [3,[67][68][69] and the use of growth factors [70][71][72][73] that support cell differentiation and proliferation, have provided new opportunities in the field of tissue engineering. At present, tissue engineering methods generally require the use of a porous scaffold that serves as a matrix for initial cell attachment and subsequently for tissue formation in vitro and in vivo. Up to now scaffolds made from biomaterials have temporarily substituted the extracellular matrix (ECM). Such biomaterials can be of natural origin, such as organic collagen [74][75][76], fibrin glue [77][78][79], hyaluronic acid [80][81][82] or the inorganic-like coralline [83,84]. Synthetic polymeric materials have also been investigated, including, for example, aliphatic, copolyesters [85][86][87], polyhydroxyalkanoates [88][89][90] and polyethylene glycol [91,92], or inorganic materials, such as hydroxyapatite [48,93,94], tricalciumphosphate [95,96], glass ceramics and glass [97][98][99].The intrinsic material properties, such as the mechanical [100] or thermal [101,102] be...

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Section: Stereolithographic Working Principlesmentioning

confidence: 99%

Design and preparation of polymeric scaffolds for tissue engineering

Weigel

Schinkel

Lendlein

2006

Expert Review of Medical Devices

207

154

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“…These scaffolds have typically been built from a single material when directly built on a commercial system. For example, polypropylene fumarate/tri-calcium phosphate (PPF/TCP) has been directly built on a stereolithography system taking advantage of its photopolymerization properties (Cooke et al 2002). Hutmacher and colleagues (Zein et al 2002) have been able to directly build polycaprolactone using a Stratasys fused deposition modeling (FDM™) system.…”

Section: Fabrication Of Tissue Engineering Scaffoldsmentioning

confidence: 99%

Additive/Subtractive Manufacturing Research and Development in Europe

Beaman¹,

Atwood²,

Bergman³

et al. 2004

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Public reporting burden for the collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden, to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to a penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. REPORT DATE SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION/AVAILABILITY STATEMENTApproved for public release; distribution unlimited SUPPLEMENTARY NOTESThe original document contains color images. ABSTRACTThis report is a review of additive/subtractive manufacturing techniques in Europe. Otherwise known as Solid Freeform Fabrication (SFF), this approach has resided largely in the prototyping realm, where the methods of producing complex freeform solid objects directly from a computer model without part-specific tooling or knowledge started. But these technologies are evolving steadily and are beginning now to encompass related systems of material addition, subtraction, assembly, and insertion of components made by other processes. Furthermore, these various additive/subtractive processes are starting to evolve into rapid manufacturing techniques for mass-customized products, away from narrowly defined rapid prototyping. Taking this idea far enough down the line, and several years hence, a radical restructuring of manufacturing as we know it could take place. Not only would the time to market be slashed, manufacturing itself would move from a resource base to a knowledge base and from mass production of single use products to mass customized, high value, life cycle products. FOREWORDWe have come to know that our ability to survive and grow as a nation to a very large degree depends upon our scientific progress. Moreover, it is not enough simply to keep abreast of the rest of the world in scientific matters. We must maintain our leadership. 1 President Harry Truman spoke those words in 1950, in the aftermath of World War II and in the midst of the Cold War. Indeed, the scientific and engineering leadership of the United States and its allies in the twentieth century played key roles in the successful outcomes of both World War II and the Cold War, sparing the world the twin horrors of fascism and totalitarian communism, and fueling the economic prosperity that followed. Today, as the United States and its allies once again find themselves at war, President Truman's words ring as true as they did a half century ago. The goal set out in the Truman Administration of maintaining leadership in science has re...

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“…A rapid prototyping is one of the most interesting one and it allows for fabrication of scaffolds with predesigned external geometry and internal architecture, as well as desirable mechanical properties [2][3][4]. Using RP technology such as Solid Freeform Fabrications (SFF) it is possible to manufacture not only simple shapes but also patient-specific geometries [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of 3D hybrid microfiber/nanofiber scaffolds for bone tissue engineering

Ostrowska¹,

Jaroszewicz²,

Zaczyńska³

et al. 2014

Bulletin of the Polish Academy of Sciences Technical Sciences

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Abstract. Fabrication of scaffolds for tissue engineering (TE) applications becomes a very important research topic in present days. The aim of the study was to create and evaluate a hybrid polymeric 3D scaffold consisted of nano and microfibers, which could be used for bone tissue engineering. Hybrid structures were fabricated using rapid prototyping (RP) and electrospinning (ES) methods. Electrospun nanofibrous mats were incorporated between the microfibrous layers produced by RP technology. The nanofibers were made of poly(L-lactid) and polycaprolactone was used to fabricate microfibers. The micro-and nanostructures of the hybrid scaffolds were examined using scanning electron microscopy (SEM). X-ray microtomographical (µCT) analysis and the mechanical testing of the porous hybrid structures were performed using SkyScan 1172 machine, equipped with a material testing stage. The scanning electron microscopy and micro-tomography analyses showed that obtained scaffolds are hybrid nanofibers/microfibers structures with high porosity and interconnected pores ranging from 10 to 500um. Although, connection between microfibrous layers and electrospun mats remained consistent under compression tests, addition of the nanofibrous mats affected the mechanical properties of the scaffold, particularly its elastic modulus. The results of the biocompatibility tests didn't show any cytotoxic effects and no fibroblast after contact with the scaffold showed any damage of the cell body, the cells had proper morphologies and showed good proliferation. Summarizing, using RP technology and electrospinning method it is possible to fabricate biocompatible scaffolds with controllable geometrical parameters and good mechanical properties.

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Use of stereolithography to manufacture critical‐sized 3D biodegradable scaffolds for bone ingrowth

Cited by 496 publications

References 18 publications

Design and preparation of polymeric scaffolds for tissue engineering

Design and preparation of polymeric scaffolds for tissue engineering

Additive/Subtractive Manufacturing Research and Development in Europe

Evaluation of 3D hybrid microfiber/nanofiber scaffolds for bone tissue engineering

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