2014
DOI: 10.1016/j.arth.2013.12.026
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Use of Stepped Porous Titanium Metaphyseal Sleeves for Tibial Defects in Revision Total Knee Arthroplasty: Short Term Results

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Cited by 95 publications
(102 citation statements)
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“…This has highlighted the need for greater understanding of the biological interactions that take place when developing materials to be used in advanced surgical technologies, particularly in order to meet the requirements of what most likely will be a tighter regulatory framework [30][31][32]. We are investigating a cellular approach to enhancing soft tissue graft integration with bone using patient-derived HF-hMSCs and in this study carried out a preliminary investigation of these cells in response to a standard, Ti interference screw which is increasingly used clinically for ACL repair particularly when undertaking revision surgeries [33,34]. Previous reports have demonstrated the in vitro attachment of MSCs to Ti surfaces, and this is confirmed by our electron micrograph data [24,35].…”
Section: Discussionmentioning
confidence: 99%
“…This has highlighted the need for greater understanding of the biological interactions that take place when developing materials to be used in advanced surgical technologies, particularly in order to meet the requirements of what most likely will be a tighter regulatory framework [30][31][32]. We are investigating a cellular approach to enhancing soft tissue graft integration with bone using patient-derived HF-hMSCs and in this study carried out a preliminary investigation of these cells in response to a standard, Ti interference screw which is increasingly used clinically for ACL repair particularly when undertaking revision surgeries [33,34]. Previous reports have demonstrated the in vitro attachment of MSCs to Ti surfaces, and this is confirmed by our electron micrograph data [24,35].…”
Section: Discussionmentioning
confidence: 99%
“…This reconstructive approach requires careful preoperative preparation, meticulous operative technique to maximize surface contact between the allograft and the host bone, availability of large structural allografts, and considerable experience in complex knee arthroplasty [26,34]. Advantages of this technique include relative cost effectiveness, the ability to create any shape or size of construct according to the bone defect, excellent support of the revision implant, the potential for long-term biologic integration of the graft restoring host bone stock, and the potential for ligamentous reattachment [2]. Disadvantages include technical difficulty and prolonged operative times required to fashion the grafts, limited availability of adequate graft, nonunion, delayed union, collapse, graft resorption, graft infection, and the possibility of disease transmission [2,34].…”
Section: Bulk Structural Allograftsmentioning
confidence: 99%
“…However, cones and sleeves differ at the interface of the augment with the revision prosthesis. Metaphyseal sleeves are implant-specific and mated to the revision implant by a Morse taper and therefore avoid the necessity of cement in the final construct [2,6]. Conversely, a variety of prosthetic devices can be cemented into the inner, central surface of many metaphyseal cone designs [34].…”
Section: Metaphyseal Cones and Sleevesmentioning
confidence: 99%
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