Use of spectroscopic process analytical technology for rapid quality evaluation during preparation of CHO cell culture media
Jianfa Ou,
Wanyue Cui,
Yuxiang Zhao
et al.
Abstract:Media preparation parameters contribute significantly to media quality, cell culture performance, productivity, and product quality. Establishing proper media preparation procedures is critical for ensuring a robust CHO cell culture process. Process analytical technology (PAT) enables unique ways to quantify assessments and improve media quality. Here, cell culture media were prepared under a wide range of temperatures (40–80°C) and pH (7.6–10.0). Media quality profiles were compared using three real‐time PATs… Show more
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