Use of Sotrovimab in a Pregnant Patient With COVID-19 Infection

Abstract

For individuals with mild-to-moderate coronavirus disease 2019 (COVID-19, caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]), monoclonal antibodies (MOABs) are known to prevent progression of the disease and hospitalization. Pregnant women, who are at an increased risk of severe COVID-19 infection, have been significantly underrepresented in studies for MOAB treatments, especially sotrovimab. Specifically, there has only been one case reported of a pregnant woman using sotrovimab successfully. We report a second such patient -an unvaccinated 21-year-old, COVID-19-positive, 16-week pregnant woman who was followed closely over the next 60 days post-MOAB infusion. We noted prevention in the progression of the disease and hospitalization without any fetal/pregnancy-related complications.

Outcomes of pregnant women exposed to Sotrovimab for the treatment of COVID-19 in the BA.1 Omicron predominant era (PRESTO)

“…Sotrovimab, a monoclonal antibody with efficacy against SARS-CoV-2 including certain Omicron variants (BA.1 and BA.1.1), was authorized and used for the treatment of mild to moderate COVID-19. Limited data exists regarding its safety and efficacy in pregnant women [ 1 , 2 ]. Thus, data is needed on safety and treatment outcomes associated with the use of sotrovimab in pregnancy, a condition that confers a greater risk of severe COVID-19.…”